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Started By
Message
re: Coronavirus Disease 2019 (COVID-19) ***W.H.O. DECLARES A GLOBAL PANDEMIC***
Posted on 2/27/20 at 9:29 am to WaWaWeeWa
Posted on 2/27/20 at 9:29 am to WaWaWeeWa
quote:
The virus uses the outreaching spike protein to hook on to the host cell, but normally this protein is inactive. The cleavage site structure’s job is to trick the human furin protein, so it will cut and activate the spike protein and cause a “direct fusion” of the viral and cellular membranes.
Compared to the Sars’ way of entry, this binding method is “100 to 1,000 times” as efficient, according to the study.
Oh yeah.. that doesn't sound like it was cooked up in a lab or anything
1
Posted on 2/27/20 at 9:34 am to Scruffy
quote:
That is a major issue of the Democratic policies of those cities.
They have created massive plague zones and have done nothing to improve the situation.
No doubt, but that's not going to be the headline. The initial headlines people will remember will be the numbers of deaths, not that they were all suffering from compromised immune systems already.
Posted on 2/27/20 at 9:36 am to rds dc
quote:
I couldn't get my sour barrel moved to the new place and had to dump it
Ouch! That had to hurt.
quote:
Also, I found a few bottles of your stuff while packing and have them in the fridge.
Posted on 2/27/20 at 9:39 am to Bard
quote:
No doubt, but that's not going to be the headline. The initial headlines people will remember will be the numbers of deaths
Remember when CNN, et al, were talking about all the "Fear and Stigma" Trump was causing because he wanted a travel ban to China.
Posted on 2/27/20 at 9:42 am to jmcwhrter
Jesus fricking Christ, you people are worse than the media acting like industry experts on the particulars of blowout preventers during Deepwater Horizon.
You wouldn’t know an intron or an extron if it bit you on the arse, and yet you jump to judgement.
Look, the article cites both HIV and Ebola having similar activity. Viruses with basically zero relation to each other. Hell, the proteins of the two viruses are written backwards compared to the other. The only thing they have in common is that they are scary words for the general public.
And yet they are cited to share this trait.
Don’t you think the logical conclusion is that this is apparently commonplace in the biochemical world which you are previously unaware of? As opposed to a mad scientist going grocery shopping for the worst traits that nature can provide.
Talk to me about engineered bioweapons when it’s a flu virus that excretes the glycoproteins Ebola has that destroys vascular tissue.
You wouldn’t know an intron or an extron if it bit you on the arse, and yet you jump to judgement.
Look, the article cites both HIV and Ebola having similar activity. Viruses with basically zero relation to each other. Hell, the proteins of the two viruses are written backwards compared to the other. The only thing they have in common is that they are scary words for the general public.
And yet they are cited to share this trait.
Don’t you think the logical conclusion is that this is apparently commonplace in the biochemical world which you are previously unaware of? As opposed to a mad scientist going grocery shopping for the worst traits that nature can provide.
Talk to me about engineered bioweapons when it’s a flu virus that excretes the glycoproteins Ebola has that destroys vascular tissue.
This post was edited on 2/27/20 at 9:44 am
Posted on 2/27/20 at 9:47 am to SuperSaint
quote:quote:pics?
apocalypse porn
I googled it.
Posted on 2/27/20 at 9:57 am to Volvagia
Well enlighten us Volvagia since you are the informed one (and I don't mean that sarcastically).
It makes sense in hindsight that if SARS was dependent on the ACE2 receptor, it would have been significant in Asia and not in most of the other developed world. I know we discussed the whole ACE2 receptor many pages ago, where the initial hunch was that because it was related to SARS it would only be big in Asia.
And the initial reports of using HIV drugs to treat this seemed strange, but completely matches with this story about this coronavirus using a different receptor than SARS. And the fact that this has spread globally would point to the transmission being different than SARS in some critical ways.
It makes sense in hindsight that if SARS was dependent on the ACE2 receptor, it would have been significant in Asia and not in most of the other developed world. I know we discussed the whole ACE2 receptor many pages ago, where the initial hunch was that because it was related to SARS it would only be big in Asia.
And the initial reports of using HIV drugs to treat this seemed strange, but completely matches with this story about this coronavirus using a different receptor than SARS. And the fact that this has spread globally would point to the transmission being different than SARS in some critical ways.
Posted on 2/27/20 at 9:59 am to TigerstuckinMS
If the Pope has it, how fricked are the rest of us?
Daily Mail
Daily Mail
quote:
Pope Francis cancelled an event Thursday due to a 'slight indisposition'
quote:
Comes a day after he was seen coughing and blowing his nose during Mass
quote:
Earlier in the day he met crowds where he kissed faces and touched hands
quote:
Italy is currently in the midst of a coronavirus outbreak, with towns in lockdown
Posted on 2/27/20 at 10:09 am to Volvagia
quote:
Look, the article cites both HIV and Ebola having similar activity. Viruses with basically zero relation to each other. Hell, the proteins of the two viruses are written backwards compared to the other. The only thing they have in common is that they are scary words for the general public.
I Agree, i wasnt trying to insinuate this is evidence of a lab developed virus. I just thought it was interesting that there is SPECULATION that the spike protein could behave differently than SARS. I say speculation because this hasn't had much peer review.
In addition, there are a few things that don't make sense in the article. They claim that SARS doesn't use the spike protein, that's definitely false. So I want to read the paper myself before making a final judgement
This post was edited on 2/27/20 at 10:13 am
Posted on 2/27/20 at 10:09 am to boxcarbarney
quote:
If the Pope has it, how fricked are the rest of us?
Pope is old and Pope probably comes in contact with more humans than rest of us.
Posted on 2/27/20 at 10:11 am to boxcarbarney
Just looking at Italy... the number of deaths is currently at 14. On Saturday there were only 130 cases. How many of those 14 deaths are from the original 130 cases? My guess would be most of them.
Posted on 2/27/20 at 10:11 am to Volvagia
quote:
Jesus fricking Christ, you people are worse than the media acting like industry experts on the particulars of blowout preventers during Deepwater Horizon.
You wouldn’t know an intron or an extron if it bit you on the arse, and yet you jump to judgement.
Look, the article cites both HIV and Ebola having similar activity. Viruses with basically zero relation to each other. Hell, the proteins of the two viruses are written backwards compared to the other. The only thing they have in common is that they are scary words for the general public.
And yet they are cited to share this trait.
Don’t you think the logical conclusion is that this is apparently commonplace in the biochemical world which you are previously unaware of? As opposed to a mad scientist going grocery shopping for the worst traits that nature can provide.
Talk to me about engineered bioweapons when it’s a flu virus that excretes the glycoproteins Ebola has that destroys vascular tissue.
Yea, that article is trash. SARS-CoV-2 is a lineage B betacoronaviruses and you can't just lump it in with generic discussions of other viruses. However, some recently published research does indicate that SARS-CoV-2 is efficient at using ACE2 but that doesn't mean it is engineered weapon. That article is the equivalent of saying, "this dark beer I'm drinking must be from Ireland because I remember drinking a Guinness one time and they make those in Ireland."
Posted on 2/27/20 at 10:12 am to boxcarbarney
The Independent is now reporting Iran's vice president has it
LINK
LINK
quote:
Iran's vice-president has been diagnosed with coronavirus, state media have reported, as the country struggles to continue to spread of the disease.
Posted on 2/27/20 at 10:14 am to lsu13lsu
Symptoms listed on CDC website:
Shortness of breath, mild to severe respiratory issues, coughing, and low grade fever.
So pretty sure my wife has this. We went to Hawaii and the end of January where there are a bunch of Asians.
Consequently, my wife also looks Asian.
Scruffy can you give me quarantine instructions and how to intubate?
Fyi: we are in NO for the past two weeks so you frickers are screwed.
Shortness of breath, mild to severe respiratory issues, coughing, and low grade fever.
So pretty sure my wife has this. We went to Hawaii and the end of January where there are a bunch of Asians.
Consequently, my wife also looks Asian.
Scruffy can you give me quarantine instructions and how to intubate?
Fyi: we are in NO for the past two weeks so you frickers are screwed.
Posted on 2/27/20 at 10:14 am to CivilTiger83
quote:
It makes sense in hindsight that if SARS was dependent on the ACE2 receptor, it would have been significant in Asia and not in most of the other developed world. I know we discussed the whole ACE2 receptor many pages ago, where the initial hunch was that because it was related to SARS it would only be big in Asia.
Must have happened when I was out of the thread for a few days.....I know some stuff about ACE2 in general but not how he applies here. ACE2 is involved with core biological functions that tend to be conserved heavily. As far as I know there isn’t much variation of expression along ethnic boundaries.
There is a function of it being more heavily expressed as you get older: which is probably a major contributor to why mortality begins to spike sharply as you approach 60.
quote:
And the initial reports of using HIV drugs to treat this seemed strange, but completely matches with this story about this coronavirus using a different receptor than SARS. And the fact that this has spread globally would point to the transmission being different than SARS in some critical ways.
Most of the drugs I’m aware of don’t target these points however. Biochemistry tends to be highly conserved, so the truck is often trying to find something critical to life or the pathogen but not for the host. And even then, you get lots of side effects from incidental reactions throughout the body.
So the drug would prefer to stay far far away from something with ACE2 interactions.
The drugs target things like viral proteases that does post-translational processing of proteins before doing this step (which is a tangentially related topic here: the protein that interacts with the receptor is more effective after processing) or reverse transcriptase, an enzyme which has only marginal long term function in the human body but is critical for replication of certain viruses.
Again, if something specific was brought up you would like me comment to...please link
Posted on 2/27/20 at 10:17 am to WaWaWeeWa
quote:Yes and yes.
Just to be clear, you don't think 5% of cases will be critical? And you think there will be a lower mortality than the flu?
quote:I have seen SK’s numbers and they are now running the most comprehensive testing program out there.
How up to date are you on the number in Singapore and South Korea?
I could end up wrong, but I suspect that, as more data arrives, the trend will reduce.
Posted on 2/27/20 at 10:20 am to Scruffy
The big problem is we know the numerator for the reported mortality and not the denominator.
Over time, as the denominator is more accurately honed in on, I would posit that 5% (to use that %) is going to come down greatly.
Over time, as the denominator is more accurately honed in on, I would posit that 5% (to use that %) is going to come down greatly.
This post was edited on 2/27/20 at 10:21 am
Posted on 2/27/20 at 10:31 am to Scruffy
That is not even close to any of the numbers we have seen so far, but I guess time will tell
I think the Diamond Princess is probably the best case study so far. There was close monitoring, controlled environment, and aggressive treatment.
3,700 passengers
705 infections
36 critical (5%)
4 dead
If we assume those critical patients have ARDS then they have a 50% chance of surviving, which would put the CFR at 2.6% in the long run. That would make everything about the diamond princess exactly like the China numbers.
Only caveat is that the Diamond Princess has an older average age. So the numbers there could be inflated. and the China numbers could also be inflated by an overwhelmed healthcare system in Wuhan.
I think the Diamond Princess is probably the best case study so far. There was close monitoring, controlled environment, and aggressive treatment.
3,700 passengers
705 infections
36 critical (5%)
4 dead
If we assume those critical patients have ARDS then they have a 50% chance of surviving, which would put the CFR at 2.6% in the long run. That would make everything about the diamond princess exactly like the China numbers.
Only caveat is that the Diamond Princess has an older average age. So the numbers there could be inflated. and the China numbers could also be inflated by an overwhelmed healthcare system in Wuhan.
Posted on 2/27/20 at 10:32 am to Volvagia
I’m now hearing reports on Twitter that the virus has JUMPED SPECIES into dogs, which causes them to aggressively attempt to spread the virus.
Tell me again how this wasn’t engineered?
Video of a Chinese woman fighting for her life:
Tell me again how this wasn’t engineered?
Video of a Chinese woman fighting for her life:
This post was edited on 2/27/20 at 10:35 am
Posted on 2/27/20 at 10:34 am to Volvagia
That dog didn't want to be dinner is all.
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