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New weight-loss compound melts fat without curbing appetite — and preserves muscle

Posted on 9/2/26 at 9:16 am
Posted by CAD703X
Liberty Island
Member since Jul 2008
94801 posts
Posted on 9/2/26 at 9:16 am
Mingo finna be really pissed off!

LINK

quote:

When the researchers combined TOFA with existing obesity drugs such as semaglutide or tirzepatide, the combination treatments produced greater reductions in body weight and improvements in blood sugar, insulin and triglyceride levels than either drug alone.

Mice treated with TOFA maintained body weights close to control levels after treatment ended, while mice previously given semaglutide began rapidly regaining weight.


Hostess Twinkie binge eating [ON] OFF
Posted by Gifman
Captiva, FL
Member since Jan 2021
19716 posts
Posted on 9/2/26 at 9:21 am to
There’s no free lunches in nature.
Posted by tiggerthetooth
Big Momma's House
Member since Oct 2010
64769 posts
Posted on 9/2/26 at 9:21 am to
quote:

Mice


Lol, outcomes in mice are nearly always irrelevant.
Posted by chew4219
Member since Sep 2009
3241 posts
Posted on 9/2/26 at 9:22 am to
Or….Eli Lilly could just come to market with Retatutride and a reasonable price and not $1200/10mg.
Posted by slidingstop
Member since Jan 2025
2642 posts
Posted on 9/2/26 at 9:23 am to
quote:

When the researchers combined TOFA with existing obesity drugs such as semaglutide or tirzepatide, the combination treatments produced greater reductions in body weight and improvements in blood sugar, insulin and triglyceride levels than either drug alone.

Mice treated with TOFA maintained body weights close to control levels after treatment ended, while mice previously given semaglutide began rapidly regaining weight.


How long till the weight loss industry kills this research?

And all the researchers too
Posted by Bard
Definitely NOT an admin
Member since Oct 2008
60384 posts
Posted on 9/2/26 at 9:23 am to
I'm waiting to see what the "possible side effects" are.

Electrically-charged urination? Hair may smell like wet dog? Fecal excretion through the toes? Blue skin?
Posted by UtahCajun
Member since Jul 2021
7522 posts
Posted on 9/2/26 at 9:29 am to
quote:

I'm waiting to see what the "possible side effects" are.

Electrically-charged urination? Hair may smell like wet dog? Fecal excretion through the toes? Blue skin

All worth it just to be able to live your best life

At least that is what the advertisements will show us.
Posted by St Augustine
The Pauper of the Surf
Member since Mar 2006
72541 posts
Posted on 9/2/26 at 9:31 am to
It’s pretty obvious they’re going to be able to refine these drugs into something really positive for a lot of people in the very near future with ever decreasing side effects. It won’t be perfect and living a great lifestyle is obviously preferable. In the real world however I’m hopeful that these will eventually help a lot of chronic diseases of western cultures.
Posted by ReauxlTide222
St. Petersburg
Member since Nov 2010
92498 posts
Posted on 9/2/26 at 9:35 am to
Is there any chance giving weak people cheat code drugs like this will affect things like our food industry?

I know it’s already a shite show, but would this not cause it to get even worse?
Posted by DMagic
#MuhChambliss
Member since Aug 2010
50953 posts
Posted on 9/2/26 at 9:38 am to
They'll turn you into a ghoul like Fallout
Posted by CocomoLSU
Inside your dome.
Member since Feb 2004
157397 posts
Posted on 9/2/26 at 9:38 am to
quote:

Mice


Lol, outcomes in mice are nearly always irrelevant.

What's funny is picturing them putting mice on little workout benches and having them max out on bench presses to see if their muscles were preserved or not.

This post was edited on 9/2/26 at 9:39 am
Posted by Marlboro Smooth
Member since Dec 2025
154 posts
Posted on 9/2/26 at 9:46 am to
Anything to see less fatties walking around

Nothing quite as disgusting as the average fatty
Posted by SoDakHawk
South Dakota
Member since Jun 2014
10924 posts
Posted on 9/2/26 at 9:47 am to
Don't know why people are complaining. A wonder drug that can control weight and cure diabetes. They should be pumping it into our water supply for free.

This fat pill could save our health care system.
Posted by SallysHuman
Lady Palmetto Bug
Member since Jan 2025
25707 posts
Posted on 9/2/26 at 9:51 am to
quote:

In the real world however


Exactly. Working, commuting, house chores, kids.. not everyone can always make the time for the right choices consistently.

I’m doing mine the hard way, but I am not employed so I have time to meal plan, shop, cook, and work out.

Posted by The Torch
DFW The Dub
Member since Aug 2014
30669 posts
Posted on 9/2/26 at 9:53 am to
Eli Lilly files 6 lawsuits against businesses selling 'black market' obesity drug

They want to shut down all the grey market venders so they can charge $1,200.00 a month for something that should be $50.00.

The pharmaceutical company Eli Lilly is studying a new obesity drug called retatrutide. The drug has not yet been approved by the Food and Drug Administration, but that hasn't stopped people from selling unapproved versions.

And now, Eli Lilly is suing.

The company says it has filed six lawsuits against businesses selling what it calls "black market" retatrutide.

They include a medical spa chain in California and a compounding pharmacy in Texas. The drug company is also suing companies that sell so-called "research-only" peptides online.
Posted by HubbaBubba
North of DFW, TX
Member since Oct 2010
52692 posts
Posted on 9/2/26 at 10:01 am to
As for people who actually DO work out and track their diet and nutrition, I'd like to know if these boutique drugs can help get rid of the stubborn areas of fat that seems to take forever. I work out, run and incline walk a lot, plus carefully monitor my calories, carbs and protein intake. I would love it if I could continue what I'm doing exercise-wise and just eat what I want. I wonder how these drugs handle cholesterol because I would love to pig out on some fatty smoked Texas brisket and smoked sausage, New Orleans BBQ shrimp, eat French bread and rice, gravy smothered chicken fried steak and mashed potatoes, and man, could I ever just dive in on some Popeyes fried chicken and a Whataburger sausage, egg & cheese jalapeño bisquit and hash brown sticks. And drink real Coca Cola made with cane sugar!
Posted by RohanGonzales
Pronoun: Whatever
Member since Apr 2024
12716 posts
Posted on 9/2/26 at 10:04 am to
quote:

There’s no free lunches in nature.


nothing natural about this
Posted by EdgarAllenHoe
Member since Aug 2026
8 posts
Posted on 9/2/26 at 10:05 am to
So cocaine
Posted by CleverUserName
Member since Oct 2016
18191 posts
Posted on 9/2/26 at 10:09 am to
quote:

Or….Eli Lilly could just come to market with Retatutride and a reasonable price and not $1200/10mg.


Shiii. Bring back ephedra and you would have 300 lb people running marathons. 10-20 bucks a bottle for the old Stacker 2.

I used to take that stuff when I worked for UPS in the evening sort while in college. I would go home after a shift and run a mile to wear down the effects so I could sleep for the next day.
Posted by Auburn80
Backwater, TN
Member since Nov 2017
10248 posts
Posted on 9/2/26 at 10:15 am to
Taint infection is my favorite side effect I’ve heard so far.

Jardiance side effects:
This medicine may cause a rare but serious bacterial infection, called necrotizing fasciitis of the perineum or Fournier's gangrene, which can cause damage to the tissue under the skin in the area between and around the anus and genitals (perineum).
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