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re: German Study: 34% of healthy individuals may have a different type of immunity to COVID

Posted on 5/7/20 at 10:43 am to
Posted by baldona
Florida
Member since Feb 2016
24215 posts
Posted on 5/7/20 at 10:43 am to
quote:

WaWaWeeWa


Is that report in the OP English, I only understand about 15% of the damn words.
Posted by baldona
Florida
Member since Feb 2016
24215 posts
Posted on 5/7/20 at 10:46 am to
quote:

The two main defenses in humans are B cells and T cells. All of the antibody studies you have been hearing about are B cells.

So far no one has been exploring the possibility that T cells could be playing a role in Coronavirus.


Why is this? Honestly asking, have no idea.
Posted by BOSCEAUX
Where the Down Boys go.
Member since Mar 2008
52413 posts
Posted on 5/7/20 at 11:00 am to
quote:

So far no one has been exploring the possibility that T cells could be playing a role in Coronavirus.


This is how you get Resident Evil.
Posted by BRIllini07
Baton Rouge, LA
Member since Feb 2015
3206 posts
Posted on 5/7/20 at 1:47 pm to
quote:

Yea its a good point. But jails and nursing homes don't interact with very many people. They may have less exposure to other coronaviruses.


Another thing I'm wondering is if there's a sliding scale between susceptibility and required exposure that varies heavily in the population.

Enter South Korean call center outbreak: NIH Link

quote:

We describe the epidemiology of a coronavirus disease (COVID-19) outbreak in a call center in South Korea. We obtained information on demographic characteristics by using standardized epidemiologic investigation forms. We performed descriptive analyses and reported the results as frequencies and proportions for categoric variables. Of 1,143 persons who were tested for COVID-19, a total of 97 (8.5%, 95% CI 7.0%-10.3%) had confirmed cases. Of these, 94 were working in an 11th-floor call center with 216 employees, translating to an attack rate of 43.5% (95% CI 36.9%-50.4%). The household secondary attack rate among symptomatic case-patients was 16.2% (95% CI 11.6%- 22.0%). Of the 97 persons with confirmed COVID-19, only 4 (1.9%) remained asymptomatic within 14 days of quarantine, and none of their household contacts acquired secondary infections. Extensive contact tracing, testing all contacts, and early quarantine blocked further transmission and might be effective for containing rapid outbreaks in crowded work settings


The below links to Figure 2, with the call center seating chart.

Figure 2

So, the act of talking all day (literally) - 45% attack rate. Talking a bit over dinner, amidst other household activities - 16.2% attack rate.
Posted by Sasquatch Smash
Member since Nov 2007
25919 posts
Posted on 5/7/20 at 1:56 pm to
quote:

The below links to Figure 2, with the call center seating chart.


That seating chart is pretty interesting with the differences between the two sides.
Posted by WaWaWeeWa
Member since Oct 2015
15714 posts
Posted on 5/7/20 at 2:05 pm to
quote:

So, the act of talking all day (literally) - 45% attack rate. Talking a bit over dinner, amidst other household activities - 16.2% attack rate.


I agree. It’s really fricking strange.

Something else is at play here
Posted by WaWaWeeWa
Member since Oct 2015
15714 posts
Posted on 5/7/20 at 2:11 pm to
quote:

Is that report in the OP English, I only understand about 15% of the damn words.


quote:

Why is this? Honestly asking, have no idea.


I assume you are asking why we have only been hearing about antibodies.

Because that’s the most common and well studied part of our immune system and we already have widespread antibody testing for all types of viruses.

But it’s only a fraction of our actual defenses to pathogens.
Posted by CelticDog
Member since Apr 2015
42867 posts
Posted on 5/7/20 at 2:24 pm to
odd shaped T cells apparently prevented black plague.

same happens with Hiv.

a lot of people have the odd shaped t cell. their relatives lived ok during black.plague.
Posted by BRIllini07
Baton Rouge, LA
Member since Feb 2015
3206 posts
Posted on 5/7/20 at 3:08 pm to
quote:

That seating chart is pretty interesting with the differences between the two sides


Or even within the "diseased" side: Look at the 4th row (not including the wall) where there's someone who didn't get it - surrounded on all sides by people who did.




There study also confirms the low asymptomatic rate that others have coming out of South Korea (1.4%).

Meanwhile, most of the Western world is showing a ton of asymptomatic cases. Our disgusting relatives from way back in the day who spent their days throwing feces and dead bodies out the windows onto the streets through the dark ages may be bailing us out again.
Posted by Sasquatch Smash
Member since Nov 2007
25919 posts
Posted on 5/7/20 at 3:20 pm to
quote:

There study also confirms the low asymptomatic rate that others have coming out of South Korea (1.4%).

Meanwhile, most of the Western world is showing a ton of asymptomatic cases. Our disgusting relatives from way back in the day who spent their days throwing feces and dead bodies out the windows onto the streets through the dark ages may be bailing us out again.


Haha.

But are "our" asymptomatic cases staying asymptomatic or were they merely asymptomatic at testing? Not that I have looked, but I don't recall seeing anything on the matter.
Posted by BRIllini07
Baton Rouge, LA
Member since Feb 2015
3206 posts
Posted on 5/7/20 at 3:30 pm to
I don’t know. Another explanation may be in South Korea if you cough twice and sneeze once in a 2 week period you call yourself in as symptomatic, whereas Europeans/Americans may write that off completely and not start claiming symptoms until they’re they have a fever/are dead to the world.
Posted by WaWaWeeWa
Member since Oct 2015
15714 posts
Posted on 5/7/20 at 3:45 pm to
Not sure. It’s very frustrating that we don’t get a follow up on these reports of asymptomatic cases. Like the USS Roosevelt. Have they not followed up with the sailors? I can’t imagine no one is looking at that.
Posted by Rep520
Member since Mar 2018
10476 posts
Posted on 5/7/20 at 3:52 pm to
It's an interesting study.

Legit question for OP. What do you make of only 83% of known Covid patients having presence of the specific T Cells? Shouldn't that be 100% if the T Cells are definitively associated with Covid?
Posted by LSUBoo
Knoxville, TN
Member since Mar 2006
104052 posts
Posted on 5/7/20 at 3:55 pm to
I have a kid. He goes to daycare with other kids. Therefore I am invincible.
Posted by TH03
Mogadishu
Member since Dec 2008
172004 posts
Posted on 5/7/20 at 4:04 pm to
quote:

Layman's terms is not being fat.


It's not, but this made me laugh anyways.
Posted by Jim Rockford
Member since May 2011
105316 posts
Posted on 5/7/20 at 4:06 pm to
quote:

Our disgusting relatives from way back in the day who spent their days throwing feces and dead bodies out the windows onto the streets through the dark ages may be bailing us out again.


Fun fact: In Shakesperian times a gentlemen walking with a lady would walk next to the wall, so any feces would land on him instead of her. The insult, 'go to the wall,' in Romeo and Juliet literally meant, 'cover yourself in shite.'
Posted by Sasquatch Smash
Member since Nov 2007
25919 posts
Posted on 5/7/20 at 4:07 pm to
quote:

Not sure. It’s very frustrating that we don’t get a follow up on these reports of asymptomatic cases. Like the USS Roosevelt. Have they not followed up with the sailors? I can’t imagine no one is looking at that.



I'd have figured some of you medical science fellows would have gotten on that by now.
Posted by WaWaWeeWa
Member since Oct 2015
15714 posts
Posted on 5/7/20 at 4:23 pm to
quote:

Legit question for OP. What do you make of only 83% of known Covid patients having presence of the specific T Cells? Shouldn't that be 100% if the T Cells are definitively associated with Covid?


It may have been too early for them to develop the immunity yet, or they could have been much older and unable to mount a large enough T cell response to be detectable.

Or alternatively there may be a percentage of the population that just doesn’t develop a strong T cell response to the virus.
Posted by p0845330
Member since Aug 2013
6069 posts
Posted on 5/7/20 at 4:59 pm to
quote:

can we go to Chili’s yet?


I went Saturday. Of course I left the shithole that is Louisiana last year.
Posted by Penrod
Member since Jan 2011
55584 posts
Posted on 5/7/20 at 5:23 pm to
quote:

Please don't try to teach anyone about how immunity works. I don't have enough time or fricks to give to correct your explanation.

It’s a scientific paper that has been submitted for peer review. I read it earlier today. It was dense with terminology I did not understand, however I understood the upshot very well. If true, it means a lot of people who have not had COVID-19 are immune to it.

I have been telling my wife for a month that there are oddities in the statistics about this virus that will end up explained by one of two things: either way more people have had Covid-19 than we thought (like over 50%), or some people can’t get it. Antibody tests show that the first is not likely, therefore large numbers of people can’t get COVID-19. Why? I don’t know. But this study hypothesizes just such.

An example of the statistical oddities is that over and over we see 20 % as the top percentage of people in a highly exposed group who catch it. The Diamond Princess, for example.
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