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WaWaWeeWa
Member since Oct 2015
7930 posts
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German Study: 34% of healthy individuals may have a different type of immunity to COVID
Pre-print study

This is going to be lengthy but hang in there and I’ll explain it all.

Our body has multiple defenses to virus and bacteria. Think of it like the Army, Navy, and Air Force. The two main defenses in humans are B cells and T cells. All of the antibody studies you have been hearing about are B cells.

So far no one has been exploring the possibility that T cells could be playing a role in Coronavirus. This study demonstrates that patients that have NEVER BEEN INFECTED with coronavirus have certain T cells that react to the virus.

This means that POTENTIALLY there could be a large percentage of people that are naturally immune to the virus due to previous infections with other coronaviruses. (FYI kids pass around a lot of coronaviruses.)

This is a hypothesis but it is very interesting and it could explain why we see pockets of infection in certain areas as well as very low transmission within households of only 15%. It’s very strange that a contagious virus only has a 15% chance to infect others in the house. Some already having natural immunity would explain this.

Update:

Latest paper out of Cell

quote:

Importantly, we detected SARS-CoV-2-reactive CD4+ T cells in ~40-60% of unexposed individuals, suggesting cross-reactive T cell recognition between circulating ‘common cold’ coronaviruses and SARS-CoV-2.


The pandemic is ending because we are nearing herd immunity in most places IMO
This post was edited on 5/23 at 9:56 am


The Boat
Vanderbilt Fan
Nashville, TN
Member since Oct 2008
113992 posts

re: German Study: 34% of healthy individuals may have a different type of immunity to COVID
Layman's terms is not being fat.


ell_13
Member since Apr 2013
65890 posts
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re: German Study: 34% of healthy individuals may have a different type of immunity to COVID
O P E N U P
P
E
N
U
P


lsuroadie
LSU Fan
South LA
Member since Oct 2007
8050 posts

re: German Study: 34% of healthy individuals may have a different type of immunity to COVID
can we go to Chili’s yet?


Open Your Eyes
Member since Nov 2012
4026 posts

re: German Study: 34% of healthy individuals may have a different type of immunity to COVID
quote:

This is a hypothesis but it is very interesting and it could explain why we see pockets of infection in certain areas as well as very low transmission within households of only 15%. It’s very strange that a contagious virus only has a 15% chance to infect others in the house.


This is consistent with the infection rates from contained environments like the cruise ships and naval vessels where this should’ve been spreading like wildfire.

quote:

Some already having natural immunity would explain this.


But we’ve been told over and over again that no one has natural immunity to this novel virus.


WaWaWeeWa
Member since Oct 2015
7930 posts
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re: German Study: 34% of healthy individuals may have a different type of immunity to COVID
Now I’m going to make a huge assumption....

If we assume 34% have some type of previous natural immunity and 20% of an area like New Orleans has already been infected (estimated by some Ochsner research I’ve heard of)...

Then we are at 54% and the virus does not have very many available hosts left and we should see a naturally slowing of infections regardless of what we do with lockdowns, etc.
This post was edited on 5/6 at 6:51 pm


LegendInMyMind
Member since Apr 2019
3895 posts
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re: German Study: 34% of healthy individuals may have a different type of immunity to COVID
Literally Germans.


WaWaWeeWa
Member since Oct 2015
7930 posts
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re: German Study: 34% of healthy individuals may have a different type of immunity to COVID
quote:

Literally Germans.




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armsdealer
LSU Fan
Member since Feb 2016
566 posts

re: German Study: 34% of healthy individuals may have a different type of immunity to COVID
Please don't try to teach anyone about how immunity works. I don't have enough time or fricks to give to correct your explanation.


TulaneFan
UTEP Fan
Pearl River, LA
Member since Jan 2008
9509 posts

re: German Study: 34% of healthy individuals may have a different type of immunity to COVID
“So basically this means we need to extend the lockdown for 45 more weeks”

- John Bel Edwards


nvcowboyfan
LSU Fan
James Turner Street, Birmingham,UK
Member since Nov 2007
2484 posts

re: German Study: 34% of healthy individuals may have a different type of immunity to COVID
very interesting. This, coupled with the recent french communication about a hospitalized patient from december who they retroactively tested samples from and found them to be + for covid suggests that in addition to this virus being around much longer than previously thought, many are immune to it from past coronavirus exposures.


WaWaWeeWa
Member since Oct 2015
7930 posts
 Online 

re: German Study: 34% of healthy individuals may have a different type of immunity to COVID
It’s important to remember that none of this has been proven but it could explain a lot of the unusual patterns we are seeing with this virus.



Volvagia
LSU Fan
Fort Worth
Member since Mar 2006
48314 posts

re: German Study: 34% of healthy individuals may have a different type of immunity to COVID
quote:

If we assume 34% have some type of previous natural immunity and 20% of an area like New Orleans has already been infected (estimated by some Ochsner research I’ve heard of)...



There is zero reason to believe the two pots are separate. If this pans out, it is more likely to explain the high degree of asymptomatic/mild cases we have already seen.

Not this silent background of 100% immunity. T cells can only react after the cells are showing viral proteins so you must have an active infection.
This post was edited on 5/6 at 6:58 pm


WaWaWeeWa
Member since Oct 2015
7930 posts
 Online 

re: German Study: 34% of healthy individuals may have a different type of immunity to COVID
quote:

If this pans out, it is more likely to explain the high degree of asymptomatic/mild cases we have already seen.


I agree. But does everyone with T cell immunity develop detectable B cell immunity?

quote:

T cells can only react after the cells are showing viral proteins so you must have an active infection.


Unless they cross react with other coronaviruses like hypothesized in the paper.


S1C EM
Georgia Fan
Athens, GA
Member since Nov 2007
8914 posts

re: German Study: 34% of healthy individuals may have a different type of immunity to COVID
What about the few studies out there looking at the MMR vaccine and it’s possible effectiveness against COVID? Several researchers out there have asserted that this could explain why up to about 50 years old or so, the infection rate is not as bad and the outcomes of those infected not as severe. It apparently is 20% identical to measles and 29% identical to rubella. Thoughts?


nvcowboyfan
LSU Fan
James Turner Street, Birmingham,UK
Member since Nov 2007
2484 posts

re: German Study: 34% of healthy individuals may have a different type of immunity to COVID
I agree. I'm still thinking that the very low #'s in the west coast (california with less than 2000 deaths) leads me to believe that this was spread slowly in the fall in the west coast.


WaWaWeeWa
Member since Oct 2015
7930 posts
 Online 

re: German Study: 34% of healthy individuals may have a different type of immunity to COVID
quote:

Thoughts?



It’s possible. Tulane is researching this now. However I think it’s unlikely.

I’ll give you what I think is a better hypothesis related to this thread....

T cell function decreases with age


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51
Ollieoxenfree99
Texas A&M Fan
Member since Aug 2018
6574 posts

re: German Study: 34% of healthy individuals may have a different type of immunity to COVID
quote:

Some already having natural immunity would explain this.


Like, say, Aryans?


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wm72
New York/Roma
Member since Mar 2010
6864 posts

re: German Study: 34% of healthy individuals may have a different type of immunity to COVID

That's very interesting.

It does make me wonder though about all the prison reports lately where seemingly almost all the inmates/employees tested positive with no symptoms.

Am I assuming incorrectly that "people that are naturally immune" would not test positive?


Is it possible that there are just a lot of different variations/mutations of this virus?








Volvagia
LSU Fan
Fort Worth
Member since Mar 2006
48314 posts

re: German Study: 34% of healthy individuals may have a different type of immunity to COVID
quote:

Unless they cross react with other coronaviruses like hypothesized in the paper.



Even then.

What you describe would only mean that the T cells could identify infected cells and send a kill signal.

It doesn't directly attack loose virus like antibodies/B cells do.


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