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re: Ozempic - Semaglutide/GLP-1

Posted on 4/12/23 at 7:57 am to
Posted by Uncle JackD
Member since Nov 2007
58643 posts
Posted on 4/12/23 at 7:57 am to
Jose, what dose of MJ are you stopping your patients at? I see some stopping at 10mg and some 15mg.
Posted by jose
Houma
Member since Feb 2009
28594 posts
Posted on 4/12/23 at 8:04 am to
I have been usually stopping at either the 5mg or 7.5mg but I have a handful of folks who want to keep going to the 10mg or 12.5mg. I have zero patients on the 15mg.

The 7.5mg to 12mg is where I see the most GI side effects.

These days I am using more of the Semaglutide instead of Mounjaro since Mounjaro isn't getting covered for weight lose. I have 2 patients who are still paying the $1200-1500 for it monthly. Semaglutide is much cheaper, but less potent since it doesn't have the glucose-dependent insulinotropic polypeptide (GIP) effect like Mounjaro does.

Posted by Uncle JackD
Member since Nov 2007
58643 posts
Posted on 4/12/23 at 8:29 am to
Gotcha. Thanks. I wasn’t sure if the higher doses were specifically for T2D Or what.
Posted by lsu777
Lake Charles
Member since Jan 2004
31157 posts
Posted on 4/12/23 at 8:41 am to
quote:

These days I am using more of the Semaglutide instead of Mounjaro since Mounjaro isn't getting covered for weight lose. I have 2 patients who are still paying the $1200-1500 for it monthly. Semaglutide is much cheaper, but less potent since it doesn't have the glucose-dependent insulinotropic polypeptide (GIP) effect like Mounjaro does.



are you upping the dose on the semaglutide ( i assume wegovy?) to make up for the less potentcy? and how are you handling the GI issues?
Posted by jose
Houma
Member since Feb 2009
28594 posts
Posted on 4/12/23 at 9:13 am to
quote:

are you upping the dose on the semaglutide ( i assume wegovy?) to make up for the less potentcy?


I still start at the lowest dose which is 0.25mg for one month, because it may not be as potent for the weight loss, but the GI side effects are still there. Then we titrate up as tolerated.

quote:

and how are you handling the GI issues?


Honestly, it's a case of is it bad enough for them to continue the injections or not. Some as needed Zofran helps too.

And I need to reiterate, while the GI side effects are there, it really is rare. I see tons of folks who says they feel great and have no issues.
Posted by el Gaucho
He/They
Member since Dec 2010
53010 posts
Posted on 4/12/23 at 11:00 am to
Can we get an anecdotal study on this vs taking bronkaid
Posted by Tiger Ryno
#WoF
Member since Feb 2007
103095 posts
Posted on 4/12/23 at 11:05 am to
Thankfully my HOA banned these drugs.
Posted by jose
Houma
Member since Feb 2009
28594 posts
Posted on 4/12/23 at 11:18 am to
quote:

Thankfully my HOA banned these drugs.



HOA?

Why would anyone ban these?
Posted by trux83LSU
brandon, ms
Member since Dec 2006
2655 posts
Posted on 4/12/23 at 11:51 am to
I do the bronkaid thing. Wife is on Semaglutide. She definitely doesn’t have the same appetite I do. I’ve lost a little on bronkaid and I feel like it helps me stay at a good range. Wife is trying to lose like 40 lbs total. Has lost about 16 or so since beginning of February. She’s at 1.7 dose per week now and is really just now getting the appetite suppression over the last 2 weeks or so.
Posted by el Gaucho
He/They
Member since Dec 2010
53010 posts
Posted on 4/12/23 at 11:54 am to
If I could lose 16 pounds in 2 months I’d be stoked

Not sure if I’d have a 6 pack but worth a try
Posted by OysterPoBoy
City of St. George
Member since Jul 2013
35159 posts
Posted on 4/12/23 at 11:56 am to
quote:

HOA?

Why would anyone ban these?


His HOA is notoriously proactive.
Posted by burgeman
Member since Jun 2008
10362 posts
Posted on 4/12/23 at 12:00 pm to
quote:

HOA banned these drugs.


Tyfys on the war on drugs. Let one thing slip in, next thing you have is a bunch of stash houses and cartels slinging phen fen on the corners.
Posted by lsu777
Lake Charles
Member since Jan 2004
31157 posts
Posted on 4/12/23 at 12:04 pm to
quote:

Can we get an anecdotal study on this vs taking bronkaid


totally different mechanisms. only 75% of the results from ECA stack come from the appetite suppression effects. 25% from thermo. metabolic rate from 24mg/200mg ec stack is between 7-10.7%.

average weightloss for eca stack is 2.2 lbs/month above placebo slowing at the 4-6 month mark. 8 week average is 7.5% of body weight in the most complete meta analysis that looks at all the studies starting in 89. the appetite suppressing effects are similar to glp1 in that eca tends to slow gastric emptying. ECA stack shines like GLP-1 over 12-16 week period.

for glp-1, average weight loss on wegovy is 35lbs in 68 weeks, roughly 15% of total bodyweight. wegovy and glp-1 do so by controlling blood sugar and appetite suppression. average bodyweight was 232.

for Mounjaro (tirzepatide) the 72 week trial was 5mg caused 15% reduction, 10mg was 19.5%, 15mg was 21%. starting weight was 231 lbs.

glp1/mounjaro are actually really healthy for you overall too. but ECA is certainly a viable alternative if and emphasis on IF you are healthy and tolerate stimulants well. they can also be used in conjuntion and combined with weightlifting and a pretty strict diet....can get stupid results in a short time period.


ultimate OTC fatburning stack


for metabolic health and appetite suppresion:
EC(25/200)- up to 2 caps 3x daily. start with 1 dose in the morning and one at lunch.


for glucose control and crazy pumps
Glucovantage xt- (berberine)- start 1 cap every meal, can go to 2 iwth heavy carb meal

NA-R-ALA- 100-200mg every meal

Gymnema Sylvestre- depends on standardization but normal 1:6 standard would be 800mg every meal

Banaba leaf- @2% Corosolic Acid- 500mg per meal

for cortisol control:
Reduce Xt- 2-4 caps per day


for pure fat oxidation:

TTA-1-2g per day. some people cramp if above 1g
Rasberry Ketones- 1500-2000mg/day
ALCAR-1500mg/day


all of the above can be combined with GLP-1 but i would personally use the glp in place of the glucose control stack if it was me and titrate these things in only if you stall. GLP-1 by itself usually more than enough to induce fatloss.

combine glp-1 with 3 days progressive weight lifting program and some sembalance of eat clean(4-5 days/week) and then you will see amazing results. If you stall you can use any of the above and add in walking 2 days per week.

in the end all of this is cool, the OTC drugs and GLP-1 etc but if you do not set yourself up to maintain the fatloss using a healthy lifestyle to do so and being mindful of labels....then you are just going to go right back to where you were.
Posted by el Gaucho
He/They
Member since Dec 2010
53010 posts
Posted on 4/12/23 at 12:26 pm to
My problem is last time I went to get more bronkaid all they had was primatene that doesn’t work as good smh

Nothing tastes as good as being skinny feels

Would you recommend clen for weight loss

And guys I’m really not that fat I’m just insecure
Posted by lsu777
Lake Charles
Member since Jan 2004
31157 posts
Posted on 4/12/23 at 12:35 pm to
quote:

My problem is last time I went to get more bronkaid all they had was primatene that doesn’t work as good smh

Nothing tastes as good as being skinny feels

Would you recommend clen for weight loss

And guys I’m really not that fat I’m just insecure




no i would recommend lifting weights and stop being a skinny fat bitch
Posted by Ingeniero
Baton Rouge
Member since Dec 2013
18287 posts
Posted on 4/12/23 at 12:39 pm to
You need to swing by the gurt megathread and put gaucho in his place.
Posted by el Gaucho
He/They
Member since Dec 2010
53010 posts
Posted on 4/12/23 at 12:56 pm to
Ima just get tren then

Natures miracle drug
Posted by Loup
Ferriday
Member since Apr 2019
11323 posts
Posted on 4/12/23 at 1:05 pm to
quote:

Ima just get tren then

Natures miracle drug


I want to lift with this guy
Posted by el Gaucho
He/They
Member since Dec 2010
53010 posts
Posted on 4/12/23 at 2:01 pm to
I’m in br

I go around 6
Posted by GhostofLesticleMiles
High Plains Drifter
Member since Sep 2019
953 posts
Posted on 4/12/23 at 2:49 pm to
quote:

quote:
Can you suggest some literature or studies that have convinced/led you to prescribe this like crazy?


One

Two

Mostly just going off of clinical success of my patients. Following up every 1-3 months and seeing the weight drop without anymore than nausea vomiting and/or constipation.


Thanks for the link. Link one didn't work. What have been your defining criteria for prescription? BMI, Navel Measurement (ex. waist measurement is at least 5o% of height or greater), visual, etc.
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