re: Ozempic - Semaglutide/GLP-1

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Yep, I'd put Ozempic and any other GLP-1 agonists in the Bariatric surgery in a needle category. Typically with Bariatric surgery diets, they restrict calories a ton. Also with those surgeries, the patients don't know shite about lifting or proper nutrition. I'd theorize that anybody that was overweight but had a prior background in athletics and knew how to eat, they probably kept way more muscle.

I think Tirzepatide had an almost 25% loss at max dosage and that is Bariatric surgery levels.

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exactly, very similar

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it's crazy they've approved it down to 12 years old...with the implication being just be on it the rest of your life. That alone could bankrupt the system.

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i would hope a parent wouldnt put a pre pubescent kid on this unless they have diabetes. i would hope

That would be the goal for many, I know a few people that are not diabetic using this and other medicines while paying several hundred a month


One specifically stated the cost is fine because they spent more than that in food each month so they are now saving money

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These drugs, without resistance training as is common with the fast majority that are taking them, will make this problem even worse IMO. We should be stressing this to patients.

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But don't forget that it's likely better to use the drug to get to a point in their life so they feel good about themselves AND instruct them to lift weights and improve muscle mass. I would believe that all the benefits of weight reduction and getting out of obesity will still outweigh (pun intended) the loss of muscle mass in the short term.

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But don't forget that it's likely better to use the drug to get to a point in their life so they feel good about themselves AND instruct them to lift weights and improve muscle mass. I would believe that all the benefits of weight reduction and getting out of obesity will still outweigh (pun intended) the loss of muscle mass in the short term.

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unfortunately it is. i hate the mindset of i just want to be skinny fat as described above. if you lift the whole time, you will make way more progress but for many its such a mental thing.

Skinny fat is almost as unattractive as fat fat. I read the Wegovy Ozempic forums on Reddit, and holy hell. The number of people that bitch and moan about not wanting to exercise while taking is why you see those studies that show people gaining the weight back. ZERO self-control, and want a miracle drug. It actually is a miracle drug, one that allows you to change your lifestyle and keep it up after you lose all of the weight. People are so damn spoiled.

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I think people are giving the masses a bad wrap. If it’s based on statistics please link them, but I’m all for this drug showing people a new lifestyle. I have a family member that just started, and they’re being strict with diet and exercise to adapt to a new life.
If they shed a lot of weight and stay in the gym with a good diet, good for them and good for all who do it.

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I think this is where I'm at. I have my annual exam next week and I've been contemplating asking my physician about it. Up to this point all of my annual bloodwork has been in the good ranges. My only issue (to my knowledge) is my weight. In 18 months I've dropped 45 lbs. The process has definitely slowed this year as I moved away from a heavy cardio workout and to a resistance focused workout (PPSA). I initially started gaining weight this year after making the workout change. I started counting calories March 20th (weighed 247.1 in the morning post workout). Since tracking calories, I've dropped 11.4 lbs (235.7 today post workout). Loss has been right at 2 lbs/wk during this time. So I'm making progress counting calories and resistance training.

I could see myself stop counting calories/macros if the weight came off too easy (which would probably be a bad thing). I'm confident that I wouldn't stop the resistance training though. I hate to phrase it this way, but lifting has become almost an addiction.

I guess this is a very long-winded way to ask who are the right candidates for GLP-1 meds? I dont have diabetes and overall I'm losing weight with ups and downs. Is this something I should consider or just continue relying on hard work alone?

….

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This is going to be a 2 part question so appreciate those that can answer both:
1) for myself I am overweight at about 225 lbs for a 5’4 girl, been diagnosed as prediabetic, my cholesterol and tryglicerides always run high and I have fatty liver as well. I’ve been prescribed Ozempic within the past 6 months however I am hesitant to take bc of the cancer warning on it. Doctor tells me I shouldn’t worry but I’m still scared for the future as I’m only 30 to take something that can one day cause cancer
2) my mom is a diabetic who has kept her A1C in control but recently her A1C shot to 10% and doctor put her on Ozempic. I was hesitant for her to take bc of the cancer concern as well but felt she had no choice with such a high A1C
I said all this to ask what is the consensus on the cancer concern, is the risk worth the good in this drug?

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there have been zero reports of cancer in humans, now or during trials and no symptoms of them.

the warning is there because during the trials on rodents when they gave very high doses to find limits, high dose is compared in dose per kg of bodyweight, and in rats it caused thryroid tumors at the high doses.

there is no cancer risk


and at 30, your weight, your healthy issues....(Please dont take this the wrong way and get mad but its the truth and you need to hear it)


you are not going to live long enough to have to worry about any cancer risk because at this point you are not going to see 50. I hate to say that, but its the truth. I have very very close loved ones in same situation and if they dont make a change, it will be the same way for them.

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I know a 5’3” woman who was about 210 lbs.
She is now 140 lbs. thanks to Ozempic.

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yep known quite a few, thats why i support the use so much.