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So Pfizer is creating an Ivermectin type pill now.

Posted on 8/9/21 at 2:02 pm
Posted by Jjdoc
Cali
Member since Mar 2016
53472 posts
Posted on 8/9/21 at 2:02 pm
quote:

Advancing Our Protease Inhibitors

Defeating COVID-19 likely requires both vaccination and targeted treatment for those who contract the virus. At Pfizer, we are evaluating two antiviral protease inhibitors – one orally administered candidate.



Anybody care to know what HCQ and Ivermectin does?


LINK
Posted by teke184
Zachary, LA
Member since Jan 2007
95592 posts
Posted on 8/9/21 at 2:02 pm to
Yeah, but is there an active patent on Ivermectin?
Posted by eng08
Member since Jan 2013
5997 posts
Posted on 8/9/21 at 2:04 pm to
I believe it recently expired which is why it’s used 3rd world - it’s cheap
Posted by The Maj
Member since Sep 2016
27137 posts
Posted on 8/9/21 at 2:04 pm to
quote:

Anybody care to know what HCQ and Ivermectin does?



shite is too cheap... They have got to create something better that costs more...
Posted by GumboPot
Member since Mar 2009
118809 posts
Posted on 8/9/21 at 2:06 pm to
They are calling it hydroxiverchlorimectin.
Posted by BurntOrangeMan
Dallas TX
Member since May 2021
5628 posts
Posted on 8/9/21 at 2:08 pm to
this is the Fuaci/Pharma model. Denounce patented drugs, buy time and then roll out it's replica at a 4000% price increase.
Posted by Vacherie Saint
Member since Aug 2015
39486 posts
Posted on 8/9/21 at 2:12 pm to
Yep. It'll be chemically unique enough to get re-patented, avoid generics, and generate a captive and coerced population of billions of customers. Meanwhile, medical "experts" from the government will block doctors from treating covid with similar, generic and readily available drugs. But WE are the ones that arent woke.

Get ready for a second wave of new big pharma billionaires:
CNN Aids Link
Posted by deathvalleytiger10
Member since Sep 2009
7575 posts
Posted on 8/9/21 at 2:14 pm to
In before "it's a horse med!" or "do you buy it at the Tractor supply company?"
Posted by jonnyanony
Member since Nov 2020
9953 posts
Posted on 8/9/21 at 2:15 pm to
I don't see where that's "Ivermectin type."

There are tons of antivirals, antibiotics, antifungals and antimicrobials and they're not interchangeable.
Posted by theunknownknight
Baton Rouge
Member since Sep 2005
57316 posts
Posted on 8/9/21 at 2:16 pm to
it's a horse med!
do you buy it at the Tractor supply company?

ETA: shite
This post was edited on 8/9/21 at 2:17 pm
Posted by Hayekian serf
GA
Member since Dec 2020
2548 posts
Posted on 8/9/21 at 2:18 pm to
quote:

Yeah, but is there an active patent on Ivermectin?


No it’s cheap. Which should explain a hell of a lot.
Posted by BestBanker
Member since Nov 2011
17478 posts
Posted on 8/9/21 at 2:18 pm to

This post was edited on 8/13/21 at 8:43 pm
Posted by Vacherie Saint
Member since Aug 2015
39486 posts
Posted on 8/9/21 at 2:37 pm to
Need a doc to chime in, but "protease inhibitors" are a pretty short list of branded medications.

Ivermectin is a protease inhibitor.
Posted by Nosevens
Member since Apr 2019
10319 posts
Posted on 8/9/21 at 2:39 pm to
If either of those 2 cheap drugs are suddenly used in this treatment in the USA for their positive results in saving lives or mitigating issues then I would expect a outcry of all people to take heads of first Fauci and then Democrats for downplaying the need for them
Posted by Jjdoc
Cali
Member since Mar 2016
53472 posts
Posted on 8/9/21 at 2:41 pm to
quote:

don't see where that's "Ivermectin type."


I bet you don't see it
Posted by crazy4lsu
Member since May 2005
36311 posts
Posted on 8/9/21 at 2:43 pm to
quote:

Anybody care to know what HCQ and Ivermectin does?


Neither are technically classed as a protease inhibitor.

Ivermectin is a semisynthetic lactose derived from Streptomyces avermitilis B1a and B1b. It works by apparently paralyzing nematodes and arthropods by intensifying GABA-mediated transmission of signals in peripheral nerves.

HCQ is an anti-malarial aminoquinolone phosphate salt and immunosuppresant. As a anti-malarial drug it is a blood schizonticide which interferes with parasite metabolism through uptake in the parasites food vacuole, which inhibits heme polymerization and causes the lysis of cell membranes. As an immunosuppressant, it is thought to suppress intracellular antigen processing and loading of peptides onto MHC II molecules by increasing the pH of lysosomal and endosomal compartments, suppressing T-cell activation. Other proposed mechanisms for the immunosuppressive aspects of the medication have to do with inhibition of leukocyte chemotaxis, inhibition of DNA and RNA synthesis, and the trapping of free radicals, among others.


Posted by Jjdoc
Cali
Member since Mar 2016
53472 posts
Posted on 8/9/21 at 2:46 pm to
quote:

Need a doc to chime in


Pierre Kory, MD MPA
@PierreKory

LINK
Posted by Vacherie Saint
Member since Aug 2015
39486 posts
Posted on 8/9/21 at 2:48 pm to
am I misreading this?

quote:

Ivermectin was found as a blocker of viral replicase, protease and human TMPRSS2, which could be the biophysical basis behind its antiviral efficiency.


LINK
Posted by the808bass
The Lou
Member since Oct 2012
111524 posts
Posted on 8/9/21 at 2:49 pm to
Impossible. It’s horse paste.
Posted by Jjdoc
Cali
Member since Mar 2016
53472 posts
Posted on 8/9/21 at 2:50 pm to
I knew somebody would bring this up. so:

From the NIH:

Hydroxychloroquine Inhibits Zika Virus NS2B-NS3 Protease

quote:

Zika virus is a mosquito-transmitted flavivirus that causes devastating fetal outcomes in the context of maternal infection during pregnancy. An important target for drugs combatting Zika virus pathogenicity is NS2B-NS3 protease, which plays an essential role in hydrolysis and maturation of the flavivirus polyprotein. We identify hydroxychloroquine, a drug that already has approved uses in pregnancy, as a possible inhibitor of NS2B-NS3 protease by using a Food and Drug Administration-approved drug library, molecular docking, and molecular dynamics simulations. Further, to gain insight into its inhibitory potential toward NS2B-NS3 protease, we performed enzyme kinetic studies, which revealed that hydroxychloroquine inhibits protease activity with an inhibition constant (K i) of 92.34 ± 11.91 µM. Additionally, hydroxychloroquine significantly decreases Zika virus infection in placental cells.



LINK


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