SARS-COV-2 Vaccines and Neurodegenerative Disease

I don’t doubt it for a second

How is this any different than the impacts that would come from infection by the virus itself?

It's different because it's even less likely the vax could cause these things to even an equivalent extent than covid itself.

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PLease explain your expertise in this matter. Have you written a paper on this? How do you know there is no evidence?

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Doctor with an understanding of how vaccines and those diseases work.
i know there is no evidence because what the article suggests is nonsense and not how human physiology works. I know there's no evidence of those things because that would be groundbreaking information, yet isn't included in any lmeaningful literature.


Go ahead find a paper with evidence supporting with evidence it will do those things to cells in vivo. I'll change my tune if you can.


They suggest the spike is like a prion, which is a laughable comparison to make. They say it will cause an increase in ND diseases, yet have nothing to back it up other than saying it's convenient for pharma. Truth is it's convenient for their fear propaganda bc it's a nonsense suggestion to explain something that's been going on before covid.

But yea go ahead and believe epoch times fear propaganda. It's on the internet after all.

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Doctor

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Somewhat off topic, but I’ve asked this question a handful of times over the last year and never gotten an answer based on more than speculation -

What’s the Covid mortality rate for a healthy/fit 35 year old?

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The spike protein does not act like a prion lmao

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The reference is to the spike protein potentially causing prion diseases.

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Prion diseases are a group of severe neurodegenerative diseases that are caused by misfolded prion proteins. The most common prion disease in humans is the always-fatal sporadic Creutzfeldt-Jakob disease (CJD), which accounts for more than 85% of the cases. Prion diseases are more specifically called transmissible spongiform encephalopathies (TSEs), and infection can spread through exposure to misfolded proteins as “infective” agents, without requiring a live pathogen. PrP is the name given to the specific prion protein associated with these TSEs. Misfolded PrP proteins act as a seed or catalyst that then recruits other molecules of PrP to misfold in the same way and glom together into pathogenic fibrils.

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PrP has a unique feature that it contains multiple copies of a characteristic motif in its amino acid sequence that is called a “GxxxG” motif, also known as a “glycine zipper”. These proteins normally fold into a characteristic shape called an alpha helix, which allows the protein to penetrate the plasma membrane. The glycines in the zipper motif play an essential role in cross-linking and stabilizing alpha helices. This glycine zipper motif is also a common characteristic of many transmembrane proteins (proteins that cross the membrane of the cell).

Indeed, the coronavirus spike protein has a GxxxG motif in its transmembrane domain (specifically, GFIAG — glycine, phenylalanine, isoproline, alanine, glycine). There is a platform called “Uniprot” where you can look up the sequence of specific proteins. The Uniprot entry for the SARS-CoV-2 spike protein has five glycine zipper sequences altogether. According to J. Bart Classen, the SARS-CoV-2 spike protein has the ability “to form amyloid and toxic aggregates that can act as seeds to aggregate many of the misfolded brain proteins and can ultimately lead to neurodegeneration.”

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There's literally no evidence or possible mechanism to suggest the vax depletes proginitor B cells.

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I don't see where they say this as fact. It says plausible conclusion based on animal studies.

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It has been demonstrated in experiments with mice that aged mice have an overabundance of long-lived memory (antigen-experienced) B cells, and this is paired with an inability to generate new B cells from progenitor cells in the bone marrow, as well as impairment in the process of refinement of the antibody response in germinal centers in the spleen and the associated class switching that produces effective IgG antibodies. A significant reduction in the number of naive follicular B cells, combined with an impaired ability to convert them into mature memory B cells leaves these aged mice highly vulnerable to new infections. It is likely that the same principle applies to humans. A plausible conclusion is that aggressive vaccination campaigns accelerate the pace at which an individual’s immune system reaches an “aged” status due to exuberant generation of memory B cells in response to the artificial stimuli induced by repeated vaccination.

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I tend to believe most will die from AIDS sooner than these diseases will get them.

Only time will tell but from what I heard and read from doctors is that they’re walking petri dishes susceptible to everything bc they nuked their immune system.

Let's call it what it is: experimental gene therapy. You are being experimented on.

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How is this any different than the impacts that would come from infection by the virus itself?

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Wouldn’t spiked proteins attached to the virus body be totally different than billions of free spike proteins used as the antigen?

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The spike protein does not act like a prion lmao as well as those neurodegen diseases were increasing in prevalence before covid.

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They suggest the spike is like a prion, which is a laughable comparison to make.

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In the article, they specifically say:

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PrP has a unique feature that it contains multiple copies of a characteristic motif in its amino acid sequence that is called a “GxxxG” motif, also known as a “glycine zipper”. These proteins normally fold into a characteristic shape called an alpha helix, which allows the protein to penetrate the plasma membrane. The glycines in the zipper motif play an essential role in cross-linking and stabilizing alpha helices. This glycine zipper motif is also a common characteristic of many transmembrane proteins (proteins that cross the membrane of the cell).

Indeed, the coronavirus spike protein has a GxxxG motif in its transmembrane domain (specifically, GFIAG — glycine, phenylalanine, isoproline, alanine, glycine). There is a platform called “Uniprot” where you can look up the sequence of specific proteins. The Uniprot entry for the SARS-CoV-2 spike protein has five glycine zipper sequences altogether. According to J. Bart Classen, the SARS-CoV-2 spike protein has the ability “to form amyloid and toxic aggregates that can act as seeds to aggregate many of the misfolded brain proteins and can ultimately lead to neurodegeneration.”

Many neurodegenerative diseases have been linked to specific proteins that have prion-like properties, and these diseases are characterized as protein-misfolding diseases or proteopathies. Like PrP, prion-like proteins become pathogenic when their alpha helices misfold as beta sheets, and the protein is then impaired in its ability to enter the membrane. These diseases include Alzheimer’s, amyotrophic lateral sclerosis (ALS), Huntington’s disease and Parkinson’s disease, and each of these is associated with a particular protein that misfolds and accumulates in inclusion bodies in association with the disease.

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So, respectfully, doctor, as I read it (as a layman), at least a portion of the covid spike protein has a protein structure / amino sequence (a "GxxxG motif" / "glycine zipper") that shares similarities with those of prion proteins and/or prion-like proteins. It doesn't seem like an unreasonable hypothesis to say that if the existence of the GxxxG motif is a hallmark of protein-misfolding diseases or proteopathies, and that the spike protein in the various vaccines have a similar structure, that they have the potential to similarly result in increased incidence of protein-misfolding diseases or proteopathies.

Conclusive evidence won't exist yet, of course, as both covid and the vaccines emerged quite recently, and it takes time for multiple generations of cells to increasingly misfold or mutate in a way that would manifest as Alzheimer's or Parkinson's. But if you're objective, and I'd hope you are open minded as a doctor, then it's not a claim that should just be summarily dismissed... as it wouldn't be logical to insist on the existence of a type of evidence that will take time to acquire.

Part of their point is that the vaccines were rushed irresponsibly (in comparison to normal vax testing which goes 10 or so years and which weeds out 98% of products in trial)... That's a huge point-- if you care at all about product safety-- which you should acknowledge. The type of hypothesis these guys are putting out there for the masses is exactly the type of thing researchers and regulators should have and would have been doing if the powers that be hadn't summarily forced this product into quasi-authorized (EUA) use and begun forcing it on millions of people.

The Epoch Times article also states that they have published a peer reviewed paper with this and other info related to the general topic of safety concerns of the vaccine. I'm not directly challenging you debunk it or anything, but the issue is more than just somebody writing a "be scared of the vax" hit piece in the Epoch Times without having any sort of underlying support. I'll link it here:
people-csail-mit-edu_mRNA_vaccines_IJVTPR