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Message

re: Wash Post:Antimalarial drug touted by Trump is linked to increased risk of death in corona

Posted on 5/22/20 at 8:38 am to
Posted by Adam Banks
District 5
Member since Sep 2009
32272 posts
Posted on 5/22/20 at 8:38 am to
quote:

The evidence strong suggests so.


You are the biggest liar ever



Eh I mean this evidence DOES suggest that. Strongly suggest is Debatable.

It’s a fairly large study though and it pushes through the “must start early” complaints given they excluded those started >48 hours post diagnosis.

Randomized placebo blinded trials need to be done but this is a fairly big blow and is a piece of evidence on the other side from the low level evidence championing it. Nothing definitive but certainly enough to give pause rather than taking it like candy.
Posted by roadGator
Member since Feb 2009
141744 posts
Posted on 5/22/20 at 8:39 am to
Why are so afraid to answer?

Do you ever feel bad about stealing from taxpayers?
Posted by the808bass
The Lou
Member since Oct 2012
111805 posts
Posted on 5/22/20 at 8:39 am to
quote:

He should be pimping the Gilead drug - Remdesiver (sp) -which is flourishing in trials.

Is it though?
quote:

In this study of adult patients admitted to hospital for severe COVID-19, remdesivir was not associated with statistically significant clinical benefits.


quote:

28-day mortality was similar between the two groups (22 [14%] died in the remdesivir group vs 10 (13%) in the placebo group; difference 1·1% [95% CI -8·1 to 10·3])


LINK
Posted by tigerinDC09
Washington, DC
Member since Nov 2011
4741 posts
Posted on 5/22/20 at 8:41 am to
quote:

The drug is currently FDA approved. Doctors prescribe it. The end.


Again, i said earlier in this thread that it is safe to prescribe for prevention of Malaria.

FDA has advised against doctors prescribing it for covid outside of hospital or clinical trials.
Posted by ShortyRob
Member since Oct 2008
82116 posts
Posted on 5/22/20 at 8:41 am to
quote:

Eh I mean this evidence DOES suggest that. Strongly suggest is Debatable. It’s a fairly large study though and it pushes through the “must start early” complaints given they excluded those started >48 hours post diagnosis. Randomized placebo blinded trials need to be done but this is a fairly big blow and is a piece of evidence on the other side from the low level evidence championing it. Nothing definitive but certainly enough to give pause rather than taking it like candy.

It's definitely good that they're studying it.

Hell, if they figure out that doctors really should stop prescribing it, that's a good thing too.

The absurd part is acting like being hopeful for a drug that TONS OF DOCTORS AROUDN THE WORLD were also hopeful about, somehow makes Trump an idiot if it turns out to not be as useful as hoped.
Posted by the808bass
The Lou
Member since Oct 2012
111805 posts
Posted on 5/22/20 at 8:42 am to
quote:

Eh I mean this evidence DOES suggest that.


Without knowing the baselines of the patients being treated, it suggests nothing.

It’s asinine to blithely assert that HCQ-prescribed patients have a 45% greater chance of dying, everything else being equal. No one will believe that who knows anything about anything.
Posted by ABearsFanNMS
Formerly of tLandmass now in Texas
Member since Oct 2014
17546 posts
Posted on 5/22/20 at 8:42 am to
quote:

Steven Nissen of the Cleveland Clinic


This guy is pretty well known in the Drug world. Pretty much scares the shiznit out of Big Pharma. Any drug he doesn’t speak for is Garbage
Posted by ShortyRob
Member since Oct 2008
82116 posts
Posted on 5/22/20 at 8:42 am to
quote:

Again, i said earlier in this thread that it is safe to prescribe for prevention of Malaria.
Your own link ALSO said that THIS study does NOT address the more positive results from using hydro in COMBINATION.

You aren't responding to my full post because when I removed my boot from your arse, your bowels ended up on the floor.

Go pick them up pussy
Posted by The Maj
Member since Sep 2016
27434 posts
Posted on 5/22/20 at 8:43 am to
quote:

follow the scientific consensus.


No such fricking thing in science and there never will be...

Good grief you can't be this stupid...
Posted by the808bass
The Lou
Member since Oct 2012
111805 posts
Posted on 5/22/20 at 8:43 am to
quote:

Again, i said earlier in this thread that it is safe to prescribe for prevention of Malaria.

What about the drug makes it safe for the prevention of malaria, the treatment of RA and lupus, and dangerous to Covid patients? Any ideas?
Posted by Adam Banks
District 5
Member since Sep 2009
32272 posts
Posted on 5/22/20 at 8:43 am to
quote:



Without knowing the baselines of the patients being treated, it suggests nothing.


From the study


quote:

For each treatment group, a separate matched control was identified using exact and propensity-score matched criteria with a calliper of 0·001. This method was used to provide a close approximation of demographics, comorbidities, disease severity, and baseline medications between patients. The propensity score was based on the following variables: age, BMI, gender, race or ethnicity, comorbidities, use of ACE inhibitors, use of statins, use of angiotensin receptor blockers, treatment with other antivirals, qSOFA score of less than 1, and SPO2 of less than 94% on room air. The patients were well matched, with standardised mean difference estimates of less than 10% for all matched parameters.
Posted by tigerinDC09
Washington, DC
Member since Nov 2011
4741 posts
Posted on 5/22/20 at 8:43 am to
quote:

Eh I mean this evidence DOES suggest that. Strongly suggest is Debatable.

It’s a fairly large study though and it pushes through the “must start early” complaints given they excluded those started >48 hours post diagnosis.

Randomized placebo blinded trials need to be done but this is a fairly big blow and is a piece of evidence on the other side from the low level evidence championing it. Nothing definitive but certainly enough to give pause rather than taking it like candy.


now this is a reasonable position to have. we can debate strong vs significant but the base facts are pretty evident now.
Posted by Taxing Authority
Houston
Member since Feb 2010
57534 posts
Posted on 5/22/20 at 8:44 am to
quote:

The absurd part is acting like being hopeful for a drug that TONS OF DOCTORS AROUDN THE WORLD were also hopeful about, somehow makes Trump an idiot if it turns out to not be as useful as hoped.
It’s a sign of how out of ammo they are. Lacking valid reasons to criticize Trump... they are having to resort to contortions like this.

It’s kinda pathetic to be honest.
Posted by ShortyRob
Member since Oct 2008
82116 posts
Posted on 5/22/20 at 8:45 am to
quote:

FDA has advised against doctors prescribing it for covid outside of hospital or clinical trials.


Cool. I know what the word advised means.

It means, they've left the decision to the doctors.

Which, all reasonable people should support.

But, you have TDS, so this excludes you.
Posted by Adam Banks
District 5
Member since Sep 2009
32272 posts
Posted on 5/22/20 at 8:45 am to
quote:


It's definitely good that they're studying it.

Hell, if they figure out that doctors really should stop prescribing it, that's a good thing too.

The absurd part is acting like being hopeful for a drug that TONS OF DOCTORS AROUDN THE WORLD were also hopeful about, somehow makes Trump an idiot if it turns out to not be as useful as hoped.


Absolutely. I said from day one I think how fauci and trump handled it was perfectly appropriate for their given roles.
Fauci gave the scientific answer of “we don’t know” trump gave the answer of hope that much of America needed at the time.

The problem is this drug has gotten so politicized on BOTH sides very few are looking objectively
This post was edited on 5/22/20 at 8:46 am
Posted by the808bass
The Lou
Member since Oct 2012
111805 posts
Posted on 5/22/20 at 8:46 am to
quote:

Everyone has the same statistical rate of survival once they enter the hospital with Covid


Whoa. This is Picasso-level genius. The Sistine Chapel weeps for joy at the level of artistry on display.
Posted by tigerinDC09
Washington, DC
Member since Nov 2011
4741 posts
Posted on 5/22/20 at 8:46 am to
quote:

What about the drug makes it safe for the prevention of malaria, the treatment of RA and lupus, and dangerous to Covid patients? Any ideas?


Dr's have suggested that Covid's effect on the heart is the difference... Which is why i'm not really all that concerned about healthy people taking HCQ (outside of the supply drain for those who depend on it).
Posted by ShortyRob
Member since Oct 2008
82116 posts
Posted on 5/22/20 at 8:46 am to
quote:

The problem is this drug has gotten so politicized on BOTH sides very few are looking objectively


Let's be blunt here.

It didn't "get politicized"

The LEFT politicized it. Before that, it was just some drug that Trump mentioned in a briefing after shite TONS OF MEDICAL PROFESSIONALS cited it as a glimmer of hope.

Posted by the808bass
The Lou
Member since Oct 2012
111805 posts
Posted on 5/22/20 at 8:46 am to
quote:

Dr's have suggested that Covid's effect on the heart is the difference


I’m sure you have a link for that.
Posted by Vandyrone
Nashville, TN
Member since Dec 2012
6990 posts
Posted on 5/22/20 at 8:47 am to
quote:

Everyone has the same statistical rate of survival once they enter the hospital with Covid.


Somebody has no clue about inpatient expected mortality rates.
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