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re: The FDA approves clinical trials for medical use of MDMA for PTSD
Posted on 11/30/16 at 4:09 pm to Hawkeye95
Posted on 11/30/16 at 4:09 pm to Hawkeye95
quote:
there are a wide range of drugs that are only given in a clinical setting. I would imagine MDMA will be under this restriction, if its approved for treatment of PTSD.
If that is the case, I guess I could get behind it.
Posted on 11/30/16 at 4:12 pm to imjustafatkid
quote:
Seen it happen. Y'all believe what you want.
probably didn't happen in a vacuum. I doubt that whoever you are talking about has only done two drugs in his life (heroin and X)
My guess is that this person(s) liked to partake in script painkillers as well.
Posted on 11/30/16 at 4:17 pm to Dire Wolf
quote:
My guess is that this person(s) liked to partake in script painkillers as well.
Of course they do. People who abuse hard drugs are definitely doing other drugs as well. They don't stop doing them just because they start doing x or coke or meth or anything else. I'd put heroin a step above all of them though. It's like the last stop. It's just a natural progression for people who are out of control.
This post was edited on 11/30/16 at 4:18 pm
Posted on 11/30/16 at 4:26 pm to imjustafatkid
My point is that x to heroin doesn't make much sense as a causation.
As "cleaner" opiates have gotten harder to get that more addicts are going to heroin. Oxycotin was everywhere when I was in college. I knew several people that went to a bad place on it. It is addicting as shite with awful withdraws. This is why middle class white folk are now doing heroin.
Not because they did x at a few soundtribe shows.
Sure being in that world can lead to more drug use. However, I think the uptick in opiate use has more to do with the fact that I got an appendix removed and was given three refills of hydrocodone.
As "cleaner" opiates have gotten harder to get that more addicts are going to heroin. Oxycotin was everywhere when I was in college. I knew several people that went to a bad place on it. It is addicting as shite with awful withdraws. This is why middle class white folk are now doing heroin.
Not because they did x at a few soundtribe shows.
Sure being in that world can lead to more drug use. However, I think the uptick in opiate use has more to do with the fact that I got an appendix removed and was given three refills of hydrocodone.
Posted on 11/30/16 at 4:28 pm to Hawkeye95
Posted on 11/30/16 at 4:33 pm to HornsLife
I support this and I'm on the right.
Posted on 11/30/16 at 5:24 pm to GumboPot
quote:
Some of you guys might be interested in this book.
i have read it. at least most of the non recipe portion.
Posted on 11/30/16 at 5:25 pm to HornsLife
I volunteer for the safety testing.
Posted on 11/30/16 at 7:54 pm to Hawkeye95
Dude.
Prescription pills are one of, if not the most abused substance.
FTR I'm for this. It's one of the original reasons mdma was created.
Prescription pills are one of, if not the most abused substance.
FTR I'm for this. It's one of the original reasons mdma was created.
Posted on 11/30/16 at 8:49 pm to Hawkeye95
quote:
well MDMA addiction is a thing, the issue is that you actually won't get high if you do it too close to your last dose. I think the risk for addiction is relatively low.
this. i'd say physical addiction to MDMA is damn near impossible unless someone was trying to get addicted just for the sake of being addicted.
Posted on 12/1/16 at 8:32 am to HornsLife
Lots of ongoing research into the current practical uses for psychedelics
What's old is new...
Background for perspective:
LINK
quote:Sam Harris
Drugs and the Meaning of Life
LINK
quote:
Joe Rogan Experience #477 - Dennis McKenna & Josh Wickerham
quote:
Dennis McKenna is an ethnopharmacologist, author, and brother to well-known psychedelics proponent Terence McKenna. Josh Wickerham is the chief advisor to the ESC, Ethnobotanical Stewardship Council.
LINK
The work of:
Terrance McKenna LINK
He argues that human development /evolution was guided by plants/psychedelics...
Contemporaries argue that much of current suffering/mental health issues evolve from a disconnect from our environment / nature (distracted and mismatched society...)
quote:
Terence Kemp McKenna (November 16, 1946 – April 3, 2000) was an American ethnobotanist, mystic, psychonaut, lecturer, author, and an advocate for the responsible use of naturally occurring psychedelic plants. He spoke and wrote about a variety of subjects, including psychedelic drugs, plant-based entheogens, shamanism, metaphysics, alchemy, language, philosophy, culture, technology, environmentalism, and the theoretical origins of human consciousness. He was called the "Timothy Leary of the '90s",[1][2] "one of the leading authorities on the ontological foundations of shamanism",[3] and the "intellectual voice of rave culture".[4]
quote:
In his book Food of the Gods, McKenna proposed that the transformation from humans' early ancestors Homo erectus to the species Homo sapiens mainly had to do with the addition of the mushroom Psilocybe cubensis in its diet,[25][70][71] an event that according to his theory took place in about 100,000 BCE (this is when he believed that the species diverged from the Homo genus).[21][72] McKenna based his theory on the main effects, or alleged effects, produced by the mushroom[3] while citing studies by Roland Fischer et al. from the late 1960s to early 1970s.[73][74]
Rick Strassman
LINK
quote:
Rick Strassman (born February 8, 1952 in Los Angeles, California) is a medical doctor specialized in psychiatry with a fellowship in clinical psychopharmacology research. He has held a fellowship in clinical psychopharmacology research at the University of California San Diego and was Professor of Psychiatry for eleven years at the University of New Mexico. [1] After twenty years of intermission, Strassman was the first person in the United States to undertake human research with psychedelic, hallucinogenic, or entheogenic substances with his research on N,N-dimethyltryptamine. He is also the author of the well known book "DMT: Spirit Molecule" which summarizes his academic research into DMT and includes his own reflections and conclusions based on this research.
quote:
Psychedelic drug research[edit]
Strassman's studies, taking place between 1990 and 1995 in the General Clinical Research Center of the University of New Mexico Hospital, aimed to investigate the effects of N,N-dimethyltryptamine (DMT), a powerful psychedelic drug, that is found in hundreds of plants and every mammal that has been studied. DMT is made primarily in mammalian lung tissue, and is related to human neurotransmitter serotonin and the pineal hormone melatonin.
Strassman refers to DMT as the "spirit molecule" because its effects include many features of religious experience, such as visions, voices, disembodied consciousness, powerful emotions, novel insights, and feelings of overwhelming significance. During the project's five years, he administered approximately 400 doses of DMT to nearly five dozen human volunteers.[6][7] Strassman was the first to legally administer psychedelics to people in the United States in 20 years, and his research has widely been regarded as kicking off the "psychedelic renaissance", in which many psychedelic compounds have begun again to be scientifically studied since the early 70s.[8][9]
Strassman characterized biological and psychological effects in his first set of dose-response studies, effects consistent with activation of central and/or peripheral serotonin receptors.[10] His team published a companion article describing psychological effects and preliminary results of a new rating scale, the Hallucinogen Rating Scale, or HRS.[11] The HRS has seen wide acceptance throughout the international research community as a sensitive and specific instrument for measuring psychological effects of a wide variety of psychoactive substances, with over 45 articles documenting its use as of mid-2015. A follow-up DMT study demonstrated lack of tolerance to the psychological effects of repeated closely spaced doses of DMT, making DMT unique among classical psychedelics.[12]
More than half of Strassman’s volunteers reported profound encounters/interaction with non-human beings while in a dissociated state. Dr. Strassman has conjectured that when a person is approaching death or possibly when in a dream state, the body releases DMT in a relatively large amount, mediating some of the imagery reported by survivors of near-death experiences. However, there are no data correlating endogenous DMT activity to non-drug-related altered states of consciousness.[13] He also has theorized that the pineal gland may form DMT under certain conditions, and in 2013 researchers first reported DMT in the pineal gland microdialysate of rodents.[14]
He has detailed his research in his book DMT: The Spirit Molecule; and he co-produced a documentary film by the same name DMT: The Spirit Molecule, based on this book.[15] Dr. Strassman has also conducted similar research using psilocybin, a psychedelic alkaloid found in hallucinogenic mushrooms. In unpublished studies, he administered doses of up to 1.1 mg/kg, nearly three times the doses considered "psychedelic" in contemporary clinical research with this compound.[16] He also had permission to begin an LSD study, but he did not begin by the time he finished his DMT study.
Posted on 12/1/16 at 8:43 am to imjustafatkid
quote:
This seems like a terrible idea. It would make me feel good for a while, but after coming down off of it I would always sink into a deep, deep depression-like state. I imagine this reaction would only be worse in someone with PTSD. What do they do once popping ecstasy no longer gives them the high?
You don't do it everyday. They use it about once every couple months to resume the brains natural serotonin production. Early trials have been very successful.
Posted on 12/1/16 at 8:46 am to CCTider
also these tests are likely going to be with low doses of MDMA
microdosing LSD and other hallucinogens is supposedly a great way to treat PTSD as well
we need more scientific testing of these drugs in these settings instead of just a flat ban. i hope nobody argues that
microdosing LSD and other hallucinogens is supposedly a great way to treat PTSD as well
we need more scientific testing of these drugs in these settings instead of just a flat ban. i hope nobody argues that
Posted on 12/1/16 at 8:50 am to imjustafatkid
quote:
This seems like a terrible idea. It would make me feel good for a while, but after coming down off of it I would always sink into a deep, deep depression-like state. I imagine this reaction would only be worse in someone with PTSD. What do they do once popping ecstasy no longer gives them the high?
What do you think they're popping dirty rolls and going to a rave or something?
Posted on 12/1/16 at 8:52 am to AjaxFury
quote:
MDMA saved many marriages in the 70s when psychiatrists dosed fighting couples.
In the early 2000s, this has a similar effect on mine. Had a supplier who lived around the corner and would let me test out the new ones as they came in. Me and the wifey were fricking porno style on the reg. It was glorious.
Posted on 12/1/16 at 8:55 am to SlowFlowPro
There will always be close minded individuals in regards to drugs, even in a medical setting.
Posted on 12/1/16 at 8:57 am to CCTider
quote:
There will always be close minded individuals in regards to drugs, even in a medical setting.
Drugs are bad, mmmkay.
Posted on 12/1/16 at 8:57 am to lsu2006
quote:
This seems like a terrible idea. It would make me feel good for a while, but after coming down off of it I would always sink into a deep, deep depression-like state. I imagine this reaction would only be worse in someone with PTSD. What do they do once popping ecstasy no longer gives them the high?
What do you think they're popping dirty rolls and going to a rave or something?
Lol. Seriously. They're testing pure MDMA, not heroin and meth laced pills.
Posted on 12/1/16 at 9:40 am to CCTider
quote:
heroin laced pills.
Are a myth.
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