Posted by
Message
RollTide1987
Alabama Fan
Washington, D.C.
Member since Nov 2009
59472 posts

Scientists find no evidence of depression being caused by "chemical imbalances" in brain

Thereby making SSRIs completely useless when it comes to combatting depression.


quote:

After decades of research, there remains no clear evidence that serotonin levels or serotonin activity are responsible for depression, according to a comprehensive review of prior research led by University College London (UCL) scientists.

The major new umbrella review – an overview of existing meta-analyses and systematic reviews – was published on July 20 in the journal Molecular Psychiatry. It suggests that depression is not likely caused by a chemical imbalance, and calls into question what antidepressant medications do. This is because most antidepressants are selective serotonin reuptake inhibitors (SSRIs), which were originally said to function by correcting abnormally low serotonin levels. In fact, there is no other accepted pharmacological mechanism by which antidepressants affect the symptoms of depression.

Lead author Professor Joanna Moncrieff, a Professor of Psychiatry at UCL and a consultant psychiatrist at North East London NHS Foundation Trust (NELFT), said: “It is always difficult to prove a negative, but I think we can safely say that after a vast amount of research conducted over several decades, there is no convincing evidence that depression is caused by serotonin abnormalities, particularly by lower levels or reduced activity of serotonin.

“The popularity of the ‘chemical imbalance’ theory of depression has coincided with a huge increase in the use of antidepressants. Prescriptions for antidepressants have risen dramatically since the 1990s, with one in six adults in England and 2% of teenagers now being prescribed an antidepressant in a given year.

“Many people take antidepressants because they have been led to believe their depression has a biochemical cause, but this new research suggests this belief is not grounded in evidence.”


LINK


High C
USA Fan
viewing the fall....
Member since Nov 2012
47491 posts
 Online 

Is this the same article that was discussed a few days ago? Not being a Germans ass, asking seriously.


StringedInstruments
Auburn Fan
Member since Oct 2013
15382 posts
 Online 

I look forward to seeing the pharmaceutical companies take these off the market. (Sarcasm)


Replies (0)
Replies (0)
653
AUbagman
Auburn Fan
LA
Member since Jun 2014
10070 posts

It's repetitive thought processes and actions, which leads to self hatred and guilt. A level of discomfort has to be gone through to change the habits, so a lot of people don't do it.

Eta: But wellbutrin sure enough works for stopping nicotine. There are some uses for them.
This post was edited on 7/27 at 10:13 am


Bluefin
South Carolina Fan
The Banana Stand
Member since Apr 2011
12652 posts

quote:

University College London



Replies (0)
Replies (0)
461
teke184
LSU Fan
Zachary, LA
Member since Jan 2007
79457 posts

They saying no correlation between serotonin levels and depression or no causation between serotonin levels and depression?


Not saying to just blindly continue this because there haven’t been any other answers. Just wondering on how they came to this conclusion and if the study was done with proper measurements and so forth.


Replies (0)
Replies (0)
175
teke184
LSU Fan
Zachary, LA
Member since Jan 2007
79457 posts

Idea behind medication is supposed to be “Lessens the symptoms so you can do therapy and either fix the underlying issue or learn coping mechanisms.”

Problem is that a lot of people just take the pills and don’t do the other part.


Jim Rockford
LSU Fan
Member since May 2011
90019 posts
 Online 

quote:

Thereby making SSRIs completely useless when it comes to combatting depression.


I posted this in the other thread about the same article when it was posted last week. Before starting on Abilify
My wife had crippling panic attacks and depression so severe that the tasks of daily living were almost too much for her. Over the course of about ten days it stopped the panic attacks completely and helped her depression so much that she's able to function as an adult.

Maybe they don't understand the mechanism like they thought. Maybe it's over prescribed. But for someone with severe depression, these medicines are lifesavers. People with Agendas are going to misinterpret this study, people will go off their meds, and people will die.


Fat and Happy
LSU Fan
Baton Rouge
Member since Jan 2013
14509 posts

Yeah but pharma is gonna stay undefeated and keep slinging out pills


Replies (0)
Replies (0)
102
SaintEB
New Orleans Saints Fan
Member since Jul 2008
20037 posts

quote:

Is this the same article that was discussed a few days ago? Not being a Germans ass, asking seriously.





Are you referring to this one:

Tigerdroppings Thread

Different article. Same study.



TD SponsorTD Fan
USA
Member since 2001
Thank you for supporting our sponsors
Advertisement
Jake88
George Mason Fan
Member since Apr 2005
60130 posts
 Online 

quote:

Scientists find no evidence of depression being caused by "chemical imbalances" in brain
Is far different that what the author of the paper said...
quote:

there is no convincing evidence that depression is caused by serotonin abnormalities, particularly by lower levels or reduced activity of serotonin
What about norepinephrine, dopamine, glutamate?


Lawyered
Ole Miss Fan
The Sip
Member since Oct 2016
21370 posts
 Online 

Pfizer gets to reap the windfall profits from Zoloft for 2 decades then this comes up

Then they make the covid vaxx and Dr birx tells us they oversold the vaccines that it wouldn’t do much anyway… even bigger windfall profits for Pfizer

Hmmmmmmmm


Replies (0)
Replies (0)
143
upgrayedd
US Space Force Fan
Lifting at Tobin's house
Member since Mar 2013
129823 posts
 Online 



Replies (0)
Replies (0)
70
lsu13lsu
Member since Jan 2008
10309 posts

Things coming out:

Alzheimer's science was bogus.
Depression science was bogus.
Vaccine data was bogus.

Next up in my opinion is the Statin/Cholesterol industry.


crazy4lsu
USA Fan
Member since May 2005
32010 posts
 Online 

That's not exactly what the study says. The chemical imbalance hypothesis is also based on catecholamines. The study, even in the section quoted, is limited in its claims. It's a great study though.


Replies (0)
Replies (0)
111
lsu13lsu
Member since Jan 2008
10309 posts

quote:

What about norepinephrine, dopamine, glutamate?


Irrelevant because the study is about SSRI's. Which is a highly prescribed group of drugs.


High C
USA Fan
viewing the fall....
Member since Nov 2012
47491 posts
 Online 

I’ve been on multiple SSRI’s since my twenties. Been on Prozac for over twenty years. I can say with conviction that their effect on my depression has been minimal to none. Over time I’ve learned many coping techniques that have allowed me to function mostly normally. Why continue to take the meds, then? My best answer would be that the placebo effect is real.


teke184
LSU Fan
Zachary, LA
Member since Jan 2007
79457 posts

Problem is balancing the placebo effect with the known side effects some of these drugs have, especially after long term use.


Replies (0)
Replies (0)
70
dandyjohn
LSU Fan
Member since Apr 2009
643 posts

quote:

It's repetitive thought processes and actions, which leads to self hatred and guilt. A level of discomfort has to be gone through to change the habits, so a lot of people don't do it.


Sometimes those thought processes are there because of learned behaviors. I am a stoic and I do believe with hard work you can change your mindset, but it also has to be understood that environment changes the level of effort that it takes to do this substantially.

Someone who grows up in foster care will have a much harder time getting out of their thought patterns than someone who grew up with loving and stable parents.


Replies (0)
Replies (0)
70
TBoy
Notre Dame Fan
Kalamazoo
Member since Dec 2007
20069 posts

quote:

Thereby making SSRIs completely useless when it comes to combatting depression.

The issue of causation is vastly different than the issue of treatment. There is no evidence that an existential crisis is caused by the absence of talking to therapists, but talking to therapists can trigger profound relief. The same can be said for any multitude of things that alleviate symptoms, whether physical and mental or emotional. There is no necessary causation correlation if the treatment relieves the symptoms.

The chemical imbalance causation theory has always been unproven. It's more of a marketing pitch than anything. It never had a scientific basis.

However, there is substantial evidence that taking anti-depression meds can have relieve severe depression.

If the treatment relieves the symptoms, then SSRIs are not "completely useless when it comes to combatting depression."


Replies (0)
Replies (0)
152
Jump to page
Page 1 2 3 4 5 ... 13
Jump to page
first pageprev pagePage 1 of 13next pagelast page

Back to top

logoFollow TigerDroppings for LSU Football News
Follow us on Twitter, Facebook and Instagram to get the latest updates on LSU Football and Recruiting.

FacebookTwitterInstagram