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re: Landmark study shows that pricy drugs do little to help mental health

Posted on 7/22/22 at 11:24 am to
Posted by Limitlesstigers
Lafayette
Member since Nov 2019
3803 posts
Posted on 7/22/22 at 11:24 am to
Lack of endorphins that you get from exercising is a big one.
Posted by KiwiHead
Auckland, NZ
Member since Jul 2014
36045 posts
Posted on 7/22/22 at 11:27 am to
Maybe you should talk to your psychotherapist instead of allowing him to push it all off on the meds. Just take the happy pill.
Posted by OceanMan
Member since Mar 2010
22817 posts
Posted on 7/22/22 at 11:56 am to
quote:

people are depressed because there is a major issue/hole in their life (or several) and i believe lack of community is leading the charge in the increasing rate of depression


My personal theory is that all of the stresses that humans have traditionally had (which revolve around obtaining adequate food and shelter) have been largely alleviated in the very recent past, maybe 3-4 generations. The void is likely that appetite for stress that we have developed over thousands of years having to be satisfied, and we try to fill that void with stresses that we conjure up ourselves. I think this is especially true of otherwise responsible people that have a tough time chilling out thanks to how easy our lives have become.

It’s hard to find a rhythm in life because there feels to be something missing. Add in unfulfilling work that does little to scratch that inherent itch to struggle and you wind up with millions of people thinking there is something wrong with them.
Posted by Malik Agar
Member since Nov 2012
12076 posts
Posted on 7/22/22 at 11:57 am to
quote:

Imagine a society that subjects people to conditions that make them terribly unhappy then gives them the drugs to take away their unhappiness. Science fiction It is already happening to some extent in our own society. Instead of removing the conditions that make people depressed modern society gives them antidepressant drugs. In effect antidepressants are a means of modifying an individual's internal state in such a way as to enable him to tolerate social conditions that he would otherwise find intolerable.
This post was edited on 7/22/22 at 11:58 am
Posted by LRB1967
Tennessee
Member since Dec 2020
22958 posts
Posted on 7/22/22 at 11:58 am to
I have found that light therapy can be very helpful for depression.
Posted by WaWaWeeWa
Member since Oct 2015
15714 posts
Posted on 7/22/22 at 12:04 pm to
Completely inaccurate and misleading title. Actually it’s more of an outright lie.

I’m all for studying the effects of SSRIs and I think they are absolutely over prescribed. But your article says this…

quote:

It does not prove SSRIs don't work. However, it does suggest the drugs don't treat depression by fixing abnormally low serotonin levels.


It’s not that the drugs don’t work. It’s that they aren’t working through serotonin. There is some other mechanism that we don’t understand yet.

You need to edit your title
This post was edited on 7/22/22 at 12:05 pm
Posted by The Third Leg
Idiot Out Wandering Around
Member since May 2014
11950 posts
Posted on 7/22/22 at 12:07 pm to
I personally believe the easiest pathway to beating depression is by way of clean eating, exercise, and occasional use of psychedelic drugs to fuel introspection.
Posted by teke184
Zachary, LA
Member since Jan 2007
103158 posts
Posted on 7/22/22 at 12:07 pm to
If you have a responsible doc, the idea is for the meds to help you cope while you do therapy to help fix the underlying issues.

Intention is to eventually make it so that you don’t have to be on them. Doesn’t necessarily work.
Posted by Grateful Reb
Member since Apr 2011
8070 posts
Posted on 7/22/22 at 12:17 pm to
quote:

Using pills as a magic potion has let people avoid changing their behavior which leads to more depression and anxiety.


Not to mention the insane side effects.

“Here, take this pill for your suicidal thoughts. Oh, and it’s really not a big deal, but this pill may also cause suicidal thoughts.”
Posted by TigerDoc
Texas
Member since Apr 2004
11530 posts
Posted on 7/22/22 at 12:37 pm to
quote:

It’s not that the drugs don’t work. It’s that they aren’t working through serotonin. There is some other mechanism that we don’t understand yet.


They actually probably are working through serotonin, but through an indirect mechanism (that isn't well understood). LINK.

To say that "low serotonin" isn't responsible for depression isn't to say that raising serotonin isn't part of the mechanism of action of the meds. To make an analogy, diuretics are prescribed for heart failure and work at the level of the kidney, not the heart. Mechanism of action of a therapy doesn't necessarily address a condition's cause.
Posted by ThinePreparedAni
In a sea of cognitive dissonance
Member since Mar 2013
11315 posts
Posted on 7/22/22 at 12:42 pm to
Mood change bro

Are you a mood change denier

Trust “the science”
Posted by lsudave1
Baton Metairie
Member since Jan 2005
11662 posts
Posted on 7/22/22 at 12:50 pm to
I work in a mental hospital and I agree. There are definitely patients who have conditions like schizophrenia that cannot function without taking drugs that they have been prescribed. However, the vast majority of patients I have seen are more in need of therapy and the elimination of negative influences on their life to improve their condition.
Posted by SaintEB
Member since Jul 2008
23551 posts
Posted on 7/22/22 at 12:57 pm to
quote:

You need to edit your title


My title is straight from the author's title. He changes his, I'll change mine.
Posted by cwil177
Baton Rouge
Member since Jun 2011
29562 posts
Posted on 7/22/22 at 1:01 pm to
quote:

people are depressed because there is a major issue/hole in their life (or several) and i believe lack of community is leading the charge in the increasing rate of depression

Despite advances in communication we are increasingly isolated.
Posted by ThinePreparedAni
In a sea of cognitive dissonance
Member since Mar 2013
11315 posts
Posted on 7/22/22 at 1:04 pm to
https://www.sciencedaily.com/releases/2022/07/220720080145.htm

quote:

No evidence that depression is caused by low serotonin levels, finds comprehensive review

Date: July 20, 2022 Source: University College London

Summary: After decades of study, there remains no clear evidence that serotonin levels or serotonin activity are responsible for depression, according to a major review of prior research.


https://dtb.bmj.com/content/60/1/7

quote:

Newer generation antidepressants and withdrawal effects: reconsidering the role of antidepressants and helping patients to stop
LINK Horowitz1, Michael Wilcock2 Correspondence to Dr Mark Horowitz, University College London, London, UK; m.horowitz@ucl.ac.uk


quote:

Abstract In England, the prescribing of antidepressants, primarily the newer generation antidepressant classes, has steadily increased over recent years. There is ongoing debate about how the efficacy of these drugs is viewed, their place in therapy and the harms associated with stopping them. Much of the evidence of their efficacy comes from short-term placebo-controlled trials which tend not to include outcomes that are of greatest relevance to patients, such as social functioning or quality of life, but rather restrict outcomes narrowly to symptom measures. On such measures these studies do not demonstrate clinically significant differences from placebo for depression. A range of adverse effects are also recognised, often greater in naturalistic studies of long-term antidepressants users than those measured in short-term efficacy studies, including emotional numbing, sexual difficulties, fatigue and weight gain. There is increasing recognition that withdrawal symptoms from antidepressants are common and that these symptoms can be severe and long-lasting in some patients. Recent guidance on how to stop antidepressants in a tolerable way has been presented by the Royal College of Psychiatrists. We believe that increasing awareness about the difficulty that some patients have in stopping antidepressants should lead to more cautious prescribing practice, with antidepressants given to fewer patients and for shorter periods of time. This article discusses the perceived benefits and harms of antidepressant use.


Many mental health issues are a rejection of the current construct of modern living

Typical scenario:

Young man struggling to live in modern society. Works too much. Rarely exercises. Sleeps when he can. Drinks too much to try to escape

Patient sees his primary care physician and he’s put on medicines to control his blood pressure. Patient is unaware that a side effect may be difficulty maintaining an erection. Patient starts having issues while trying to have sex with the old lady ( another transient escape). New sexual problems now start to interfere with his relationship. Wife thinks that he’s having an affair and not interested in her

Patient sees his primary care physician and now reports that his mood is erratic but does not want to disclose that he’s having trouble sexually (nor does the PCP want to go there as talking about sex and lifestyle takes way too much time when they have a treatment plan to focus on…). Primary care physician recommends anti-depressants to “balance things out”. Patient is again unaware of sexual side effects which continue to spiral/get worse. Interpersonal relationships continue to deteriorate. Mood and mental health continue to decline. Med adjustments ensue in perpetuity…
This post was edited on 7/22/22 at 1:09 pm
Posted by dgnx6
Member since Feb 2006
86332 posts
Posted on 7/22/22 at 1:10 pm to
When you pump kids full of meth and find later they have mental problems that aren’t fixed by other drugs. Hmmm.

It’s like there is a bigger motive here. Money. And pharma advertises like a mother fricker. No other country advertises pills like we do.

frick you doctors for going a long with this shite.
Posted by crazy4lsu
Member since May 2005
39298 posts
Posted on 7/22/22 at 1:25 pm to
quote:

Mood change bro

Are you a mood change denier

Trust “the science”


Can you describe the science for me? Use paragraphs and no silly links to song lyrics that you randomly highlight for some reason. Just give it to me as dryly as possible in a few paragraphs.
Posted by Lakeboy7
New Orleans
Member since Jul 2011
28324 posts
Posted on 7/22/22 at 1:30 pm to
quote:

Typical scenario:

Young man struggling to live in modern society. Works too much. Rarely exercises. Sleeps when he can. Drinks too much to try to escape

Patient sees his primary care physician and he’s put on medicines to control his blood pressure. Patient is unaware that a side effect may be difficulty maintaining an erection. Patient starts having issues while trying to have sex with the old lady ( another transient escape). New sexual problems now start to interfere with his relationship. Wife thinks that he’s having an affair and not interested in her

Patient sees his primary care physician and now reports that his mood is erratic but does not want to disclose that he’s having trouble sexually (nor does the PCP want to go there as talking about sex and lifestyle takes way too much time when they have a treatment plan to focus on…). Primary care physician recommends anti-depressants to “balance things out”. Patient is again unaware of sexual side effects which continue to spiral/get worse. Interpersonal relationships continue to deteriorate. Mood and mental health continue to decline. Med adjustments ensue in perpetuity…





Hope everything works out man.
Posted by AUjim
America
Member since Dec 2012
3779 posts
Posted on 7/22/22 at 1:30 pm to
quote:

Lastly, we have removed responsibility. Everyone can be a victim now. No one has to take ownership in their lives.


AND there is quite literally validation for our irresponsibly formed, often inflated opinions of ourselves in the forms of the individual echo chambers that are present everywhere we turn through social media. The societal decay has been relatively incremental and somewhat subtle, but very, very real.
This post was edited on 7/22/22 at 1:45 pm
Posted by sleepytime
Member since Feb 2014
3857 posts
Posted on 7/22/22 at 2:05 pm to
quote:

It’s not that the drugs don’t work. It’s that they aren’t working through serotonin. There is some other mechanism that we don’t understand yet.


One of the theories is that SSRI’s increase a chemical in the brain called BDNF, some say it’s due to downstream Sigma1 activation. Truth is that no one knows for sure and and it’s a tangled mess trying to figure it out because everyone is wired differently.
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