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Japan pharma startup developing world-first drug to grow new teeth
Posted on 10/5/23 at 12:02 pm
Posted on 10/5/23 at 12:02 pm
quote:
A team of scientists led by a Japanese pharmaceutical startup has been working on a drug to stimulate the growth of new teeth in what would be a world-first, aiming to put it on the market by around 2030.
Toregem Biopharma Co., funded by Kyoto University, is expected to begin clinical trials on healthy adults in around July 2024 to confirm the drug's safety, after the team succeeded in growing new teeth in mice in 2018.
Most people have "tooth buds" that have the potential to become a new tooth, in addition to baby and permanent teeth, although the buds usually do not develop and subsequently disappear.
The team created an antibody drug that inhibits the protein that suppresses the growth of teeth. The drug works on these buds and stimulates their growth.
In 2018, the team also administered the drug to ferrets, which have both baby and permanent teeth similar to humans, and new teeth grew.
The team plans to hold a clinical trial for the drug from 2025 for children between 2 to 6 years old with anodontia who are born without some or all permanent teeth. The children will be injected with one dose to induce their teeth growth.
There are also hopes to utilize the drug in the future for adults who have lost teeth due to cavities.
"Missing teeth in a child can affect the development of their jaw bone," said Katsu Takahashi, co-founder of Toregem Biopharma and head of dentistry and oral surgery at Kitano Hospital in Osaka.
"We hope the drug will serve as a key to solving those problems," he said.
LINK
Posted on 10/5/23 at 12:07 pm to John88
I’ve been following this for a few months since I first heard about it, tentatively optimistic for the future. My teeth are fine now, but I had well water as a kid with no flouride, so I have tons of old work just waiting to fail and need replacing over the next fifteen to twenty years.
I’ve given some thought to what I would be willing to pay for a whole new set of real, grown teeth, even knowing how much it would suck to lose and grow new ones, and I’m currently thinking somewhere around $25k would make it an “easy” decision for me, but I would likely be willing to pay substantially more.
I’ve given some thought to what I would be willing to pay for a whole new set of real, grown teeth, even knowing how much it would suck to lose and grow new ones, and I’m currently thinking somewhere around $25k would make it an “easy” decision for me, but I would likely be willing to pay substantially more.
Posted on 10/5/23 at 12:08 pm to Joshjrn
Plot twist, the teeth grow in your arse
Posted on 10/5/23 at 12:10 pm to John88
Plot twist, it also shrinks your penis, Japanese test groups unaffected
Posted on 10/5/23 at 12:10 pm to John88
What could possibly go wrong?
Posted on 10/5/23 at 12:11 pm to Joshjrn
another potential cause of a "Zombie Apocalypse"
Posted on 10/5/23 at 12:11 pm to John88
Wafflehouse employees need to add this to their strike demands.
Posted on 10/5/23 at 12:13 pm to John88
I wonder if this works really well and becomes readily available, how it effects the dentist industry.
Posted on 10/5/23 at 12:13 pm to John88
Those Alabama residents are rejoicing today.
Posted on 10/5/23 at 12:16 pm to John88
Vagina dentata is scary stuff.
You accidentally stick it in the wrong patooty ... you lose your peen.
https://en.m.wikipedia.org/wiki/Vagina_dentata
They made a movie about it you know ....
https://en.m.wikipedia.org/wiki/Teeth_(2007_film)
You accidentally stick it in the wrong patooty ... you lose your peen.
https://en.m.wikipedia.org/wiki/Vagina_dentata
They made a movie about it you know ....
https://en.m.wikipedia.org/wiki/Teeth_(2007_film)
Posted on 10/5/23 at 12:25 pm to MrLSU
quote:
Those Alabama residents are rejoicing today.
Roll tiders bout to start getting some toothy cousin bjs.
Posted on 10/5/23 at 12:26 pm to John88
I'll be shocked if this actually works on humans. Most proposed drug treatments work well on animals but then are discovered to be useless when human trials show that they have little to no benefits and cause side effects.
Posted on 10/5/23 at 12:28 pm to SG_Geaux
quote:
What could possibly go wrong?
yall post this about every new medicine. should we not continue to try and develop new things?
yall act like they arent going to go through all kinds of trials...pretty sure this cant be politicized and rushed through like trump did with the vaccine.
Posted on 10/5/23 at 12:33 pm to John88
This has been worked on for a while. Past problems were the teeth did not know how to stop growing.
Same problem beavers and maybe nutria have. They have to keep gnawing on shite to keep wearing them down before they damage their jaws.
Same problem beavers and maybe nutria have. They have to keep gnawing on shite to keep wearing them down before they damage their jaws.
Posted on 10/5/23 at 12:48 pm to Bullfrog
I can see the commercials now…
“Side effects include…well… anything. Literally ANYTHING can happen to you! See your doctor for details and to see if Tooofsimpis is right for you!”
“Side effects include…well… anything. Literally ANYTHING can happen to you! See your doctor for details and to see if Tooofsimpis is right for you!”
Posted on 10/5/23 at 1:35 pm to John88
Bama won't be Bama after this.
Read through the thread. Should have known five people would beat me to that one.
Read through the thread. Should have known five people would beat me to that one.
This post was edited on 10/5/23 at 1:37 pm
Posted on 10/5/23 at 1:37 pm to Fun Bunch
quote:
I wonder if this works really well and becomes readily available, how it effects the dentist industry.
You gonna stop brushing your teeth or going to those cleanings now that you can take a pill to grow new teeth? Is this pill going to cure gum disease too?
This post was edited on 10/5/23 at 1:40 pm
Posted on 10/5/23 at 1:54 pm to lsu777
quote:
yall act like they arent going to go through all kinds of trials...pretty sure this cant be politicized and rushed through like trump did with the vaccine.
Well, they just caused a pandemic, so forgive me for being skeptical when it comes to safety precautions
Posted on 10/5/23 at 1:57 pm to John88
I bet they extracted some shark dna and remixed it to work on humans.
Posted on 10/5/23 at 1:59 pm to Joshjrn
quote:
I’m currently thinking somewhere around $25k would make it an “easy” decision for me
Might as well go with implants.
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