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re: Pfizer efficacy down to 42% while FDA standard for safe/effective/approval is 50%

Posted on 8/11/21 at 12:29 pm to
Posted by crazy4lsu
Member since May 2005
36548 posts
Posted on 8/11/21 at 12:29 pm to
quote:

There are TONS examples of historical pandemics where massive death tolls were observed and people eventually developed sufficient immunity combined with weakening strains to ostensibly end the pandemic.


There were very few pandemics. There might be epidemics and diseases endemic, but pandemics in a historical sense didn't really occur. Again, if you are talking about small populations at equilibrium, then you can theoretically reach herd immunity. But even in your examples, you assuming even distribution, which isn't how many viruses spread. Fecal-oral transmission has a specific distribution pattern which is by necessity different than droplet which is different than airborne. Human populations aren't at equilibrium and generally don't operate that way.

quote:

We dont yet know the full science behind these early pandemics, but to assume that in 10,000 years of humanity, none were animal borne RNA viruses that were overcome by human adaptation


Part of my Ph.D work is attempting to recreate disease patterns in orphan populations. The preponderance of evidence doesn't support widespread human immunity to most infectious diseases. Given that MHC genes are the most polymorphic in our entire genome, that suggests a different saga that played out with each infection, namely with infection, immune response, reinfection, new immune response, etc. You need very specific disease characteristics to reach natural herd immunity as well, but that's another discussion.

quote:

We also know that these viruses dont remain static, and specifically in the case of COVID-19, we arent having success keeping up with mutations via vaccinations.


Because of the specific morphology of RNA viruses. We have a chance to put selective pressure on the virus, but we will likely miss it due to many reasons.
Posted by LSUA 75
Colfax,La.
Member since Jan 2019
3729 posts
Posted on 8/11/21 at 12:31 pm to
How much emphasis are Drs.,public health departments placing on Vit D3,VitC and zinc as preventative.I’ve read several studies that checked Vitamin D levels on hospitalized patients and the vast majority were low.Yet I don’t read anybody such as NIH,CDC or Gov.Edwards medical experts pushing it.
I talk up Vit D3 and zinc to everybody I come across and very few people seem to have heard about it.
My neighbor ,retired nurse ,and her husband both were vaccinated and got COVID anyway,they weren’t taking Vit D or zinc.She was taking a multivitamin but the level of D was fairly low.They got the antibody infusion and recovered quickly.
Our family has been on VitD and zinc from the beginning and no one has gotten it.3 have been vaccinated is all,they were under pressure from their employers.
Posted by jmon
Mandeville, LA
Member since Oct 2010
8464 posts
Posted on 8/11/21 at 12:31 pm to
I did not accurately describe my argument, which is that non vaccinated people occupy a majority of hospital beds, with severe complications. I can see where my comment ties natural immunity as the same, but that was not my intent.

I agree that there are many people walking around that have had covid and have never been in the hospital.
Posted by Vacherie Saint
Member since Aug 2015
39689 posts
Posted on 8/11/21 at 12:46 pm to
quote:

There were very few pandemics.


Not true. There are many we know about and likely many more we don’t know about. Many throughout history never became pandemic only because of the static nature of man for the majority of human history.
This post was edited on 8/11/21 at 1:00 pm
Posted by STEVED00
Member since May 2007
22400 posts
Posted on 8/11/21 at 12:56 pm to
quote:

comprendo?


Excellent troll post +1.
Posted by landmanner
Louisiana
Member since May 2006
3208 posts
Posted on 8/11/21 at 1:18 pm to
quote:

FDA standard for safe


The headline says that FDA sets approval at 50% effectiveness. Is that a normal percentage for a vaccine? Does that mean all that is needed for a vaccine is it helps 50% of the people that take it?

Not the same but thank goodness the birth control pill doesnt follow those guidelines.
Posted by League Champs
Bayou Self
Member since Oct 2012
10340 posts
Posted on 8/11/21 at 1:54 pm to
quote:

especially if prior infection was more than 6 months ago.

You should be embarrassed. So much bullshite.

Studies have been completed at 6 month and 11 month intervals. EVERY SINGLE ONE confirms that natural immunity is not only increasing in test subjects (currently at 98%), but also evolving to defeat variants.

16 month immunity is the most recent study confirmation, with so many similar ongoing studies, that some are positing natural immunity could be lifelong.
Posted by rocket31
Member since Jan 2008
41819 posts
Posted on 8/11/21 at 1:55 pm to
quote:

EVERY SINGLE ONE confirms that natural immunity is not only increasing in test subjects (currently at 98%), but also evolving to defeat variants.

lesson there
This post was edited on 8/11/21 at 1:56 pm
Posted by shell01
Marianna, FL
Member since Jul 2014
793 posts
Posted on 8/11/21 at 2:17 pm to
LC, anyone vehemently disputing data should respond with data. What's your source?
Posted by Purpleblooded
Member since Dec 2019
580 posts
Posted on 8/11/21 at 2:19 pm to
VitD and zinc

How much should one person take?
Posted by Barstools
Atlanta
Member since Jan 2016
9516 posts
Posted on 8/11/21 at 2:26 pm to
That says they are effective at reducing hospitalization not effective at stoping the spread or providing immunity.

So, it's not actually a vaccine.
Posted by crazy4lsu
Member since May 2005
36548 posts
Posted on 8/11/21 at 2:27 pm to
quote:

Not true. 


And yet never developed herd immunity. The list of diseases that ravaged humanity remained remarkably constant until inoculation efforts. Diseases like Yersinia pestis, in the pneumonic form, would absolutely ravage us now. We should be thankful it takes so many tuberculosis nuclei to infect 1 person, or else we would be fricked as well.

Again, the suggestion that humans reached widespread immunity for many major diseases isn't supported by the evidence. I can go over it in excruciating detail, but I don't suppose that will convince anyone.
Posted by Diamondawg
Mississippi
Member since Oct 2006
32503 posts
Posted on 8/11/21 at 2:29 pm to
quote:

VitD and zinc

How much should one person take?
I take 50mg Zinc and 4000 units of D3. I also take a multivitamin for the Vit C. Some people take more D3 but I'm in the sun a lot.
Posted by Barstools
Atlanta
Member since Jan 2016
9516 posts
Posted on 8/11/21 at 2:29 pm to
quote:

Yeah why get a flu vaccine every year?


People that aren't elderly do this? I didn't know that was a thing. I don't know of anyone that gets flu shots.
Posted by League Champs
Bayou Self
Member since Oct 2012
10340 posts
Posted on 8/11/21 at 2:44 pm to
quote:

What's your source?

Do you trust the NIH? 8 month study.
quote:

The immune systems of more than 95% of people who recovered from COVID-19 had durable memories of the virus up to eight months after infection.

LINK

Posted by League Champs
Bayou Self
Member since Oct 2012
10340 posts
Posted on 8/11/21 at 2:49 pm to
quote:

What's your source?

How about the Mayo clinic?

LINK /
quote:

Dr. Ryan Cole, a Mayo Clinic-trained pathologist who runs the largest independent laboratory in Idaho, explained to me how infection-induced immunity is much deeper and broader. “A natural infection induces hundreds upon hundreds of antibodies against all proteins of the virus, including the envelope, the membrane, the nucleocapsid, and the spike,” said Dr. Cole, who has spent the past 16 months examining and culturing SARS-CoV-2 specimens. “Dozens upon dozens of these antibodies neutralize the virus when encountered again. Additionally, because of the immune system exposure to these numerous proteins (epitomes), our T cells mount a robust memory, as well.
Posted by Vacherie Saint
Member since Aug 2015
39689 posts
Posted on 8/11/21 at 2:54 pm to
quote:

And yet never developed herd immunity. The list of diseases that ravaged humanity remained remarkably constant until inoculation efforts.



sighs.... you dont know this. We have only a snippet of what pandemics and epidemics have plagued humanity throughout pre-history. Our contemporary knowledge of disease is a flea on the elephant of history. Logic and reason necessitate that these diseases were present. The presence of humanity across all of the inhabitable earth dating back thousands of years necessitates that they survived those diseases.

shite, we didn't even know what RNA virus was until we had already entered the vaccine era. Your assumptions are far too narrow.
Posted by League Champs
Bayou Self
Member since Oct 2012
10340 posts
Posted on 8/11/21 at 2:59 pm to
quote:

What's your source?

Bear with me, I'm sourcing only organizations that I think you will accept. Hopefully, this study from Australia highllighted on nature(dot)com works for you.

LINK

quote:

Had COVID? You’ll probably make antibodies for a lifetime

quote:

up to 11 months after infection, the researchers could still detect antibodies that recognized the SARS-CoV-2 spike protein.

Posted by League Champs
Bayou Self
Member since Oct 2012
10340 posts
Posted on 8/11/21 at 3:10 pm to
quote:

LC, anyone vehemently disputing data should respond with data.

And if you were legitimately interested in why our leaders are not discussing natural immunity, you should certainly question why something like this happens.

LINK

Why was this passage on the Mayo clinics website on herd immunity ...




changed to this?


quote:

“[T]hose who survived the 1918 flu (influenza) pandemic were later immune to infection with the H1N1 flu, a subtype of influenza A.” The Mayo Clinic pointed out that H1N1 was during the 2009-10 flu season, which would be 92 years later. That finding attested to just how powerful and long-lived natural immunity could be.

Posted by crazy4lsu
Member since May 2005
36548 posts
Posted on 8/11/21 at 3:20 pm to
quote:

sighs.... you dont know this.


Again, I've repeated what the preponderance of evidence suggests.

quote:

We have only a snippet of what pandemics and epidemics have plagued humanity throughout pre-history. Our contemporary knowledge of disease is a flea on the elephant of history. Logic and reason necessitate that these diseases were present. The presence of humanity across all of the inhabitable earth dating back thousands of years necessitates that they survived those diseases.


Again, not all diseases are distributed over a geographical area all at once. There are distinct disease vectors. I'm only going from the evidence we have on hand. New evidence will obviously change it, but we didn't develop herd immunity to relatively stable infections. As long as there are closely related reservoirs, it makes herd immunity effectively impossible for most post-Neolithic societies.

quote:

shite, we didn't even know what RNA virus was until we had already entered the vaccine era. Your assumptions are far too narrow.



And we didn't define all the aspects of immunity until the late 1980's and early 90's. I can only go from the evidence we have on hand, which suggests one conclusion.
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