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re: Letter from FDA to physicians on acetaminophen use

Posted on 9/24/25 at 12:17 pm to
Posted by cajunangelle
Member since Oct 2012
163000 posts
Posted on 9/24/25 at 12:17 pm to
They still give the basic objective to LIMIT usage in pregnancy.

No one can conclusively say so. There is always a ying to the yang disclaimer.

No one is going to lose money on the drug choice to break fevers. Just like no one lost money saying do not take motrin while pregnant.

Should geriatric people inquire to Tylenol Arthritis take two? With an unusually high dosage harming anything? Or does the quality of life outweigh someone already old?

Much like a 90 year old geriatric born with polio in pain always taking opioid's-worrying about addiction?

RFK's point is the people making decisions of tylenol versus motrin in pregnancy-- Can't always be trusted to share any absolutes much less brief studies over their palms always getting greased.

Posted by onmymedicalgrind
Nunya
Member since Dec 2012
11476 posts
Posted on 9/24/25 at 12:18 pm to
quote:

Meh. Like the man said, "There is no downside." Probably too strong, but way closer to the truth than, "There is no risk in taking these."

Well, at the population level, phrasing is critical.

As has been noted, there are two obvious downsides to me with this tylenol hysteria: 1) people may now not take it when the benefits outweigh the risks (fever is the easy example, depending on how high and timing of course) and 2) people may now take an alternative without realizing it is actually less safe, but hasn't been all over the media as being "dangerous" (i.e. ibuprofen).

Even if its not a high percentage, even low percentages matter at the population level.
Posted by Wildcat1996
Lexington, KY
Member since Jul 2020
9574 posts
Posted on 9/24/25 at 12:19 pm to
Yo. moron. A study to establish a causal relationship would require a placebo-controlled study and an 8-10 year follow-up to see whose kids develop a neurological disorder.

We are talking about an OTC analgesic. There isn't an IRB in the world that would approve such a study, not even on Chinese prisoners.

Jeebus.
This post was edited on 9/24/25 at 12:23 pm
Posted by onmymedicalgrind
Nunya
Member since Dec 2012
11476 posts
Posted on 9/24/25 at 12:21 pm to
quote:

Nice try at the gotcha.

Its not a gotcha, and you proved my point...

quote:

you surely know other otc pain relievers are also not recommended for use in pregnancy.


Is ibuprofen just "not recommended" or is there a stronger stance on its using during pregnancy?

I can lead you to water, but can't make you drink.
Posted by SallysHuman
Lady Palmetto Bug
Member since Jan 2025
15290 posts
Posted on 9/24/25 at 12:24 pm to
quote:

I can lead you to water, but can't make you drink.


Lead yourself to water.

You are a prime example on this board of a fart sniffing medical professional more interested in gatekeeping than discussing. I've been down the rabbit hole with your insufferable self. No thanks.
Posted by cajunangelle
Member since Oct 2012
163000 posts
Posted on 9/24/25 at 12:24 pm to
the one with the 1980's pager wants a gotcha on Trump/RFK so bad

hey tangerine pager from the 80's, have your wife/GF/SO take all the tylenol they want in the second and last trimester. no one is forcing anything.

your pager is going off call 910-867-5309



Not making fun...medical professionals had these but so did helicopter rich kids and drug dealers.

This post was edited on 9/24/25 at 12:28 pm
Posted by LegendInMyMind
Member since Apr 2019
72180 posts
Posted on 9/24/25 at 12:24 pm to
quote:

Trump should have never been in front of the microphone

I have to agree. It is hard to square what he said and what was actually directed by the FDA. It is problematic.
Posted by onmymedicalgrind
Nunya
Member since Dec 2012
11476 posts
Posted on 9/24/25 at 12:27 pm to
quote:

You are a prime example on this board of a fart sniffing medical professional more interested in gatekeeping than discussing. I've been down the rabbit hole with your insufferable self. No thanks.

Aww, Sensitive Sally.
Posted by Dixie2023
Member since Mar 2023
4667 posts
Posted on 9/24/25 at 12:28 pm to
I dont believe a thing the FDA says.
Posted by GetmorewithLes
UK Basketball Fan
Member since Jan 2011
22383 posts
Posted on 9/24/25 at 12:30 pm to
quote:

Holy shite. That’s really what you get from that? I read it as - only use it when absolutely needed because there is mounting evidence it creates more issues than it solves.


Acetominiphen is touted as ultra safe but when I developed some arthritic issues in my neck and was taking it routinely my wife told me to stop. Her friend’s husband had just died from regular tylenol use for back pain. It killed his liver and eventually killed him. I also found out the hard way that if you take the max recommended dose every day for about two wks you get rebound headaches when it wears off. I was waking up at 2AM to take another dose.
Posted by how333
Member since Dec 2020
4061 posts
Posted on 9/24/25 at 12:30 pm to
"casual relationship" ???
Posted by SammyTiger
Baton Rouge, LA
Member since Feb 2009
78394 posts
Posted on 9/24/25 at 12:31 pm to
This is one of those things that should have been put out in the normal course and scope of FDA activities

“hey we are recommending doctors discuss that tylenol has links to neurological defects especially when abused”

But RFK Jr told us months ago he’s figure out what’s causing autism by september, and now we have a press conference with the actual president talking about it. That’s overdone
Posted by LegendInMyMind
Member since Apr 2019
72180 posts
Posted on 9/24/25 at 12:32 pm to
quote:

"casual relationship" ???

Causal

quote:

causal/kô'z?l/

adjective Of, involving, or constituting a cause.

"a causal relationship between scarcity of goods and higher prices."

Indicative of or expressing a cause.Relating to a cause or causes; inplying or containing a cause or causes; expressing a cause; causative.
Similar: causative


Posted by Sofaking2
Member since Apr 2023
19765 posts
Posted on 9/24/25 at 12:32 pm to
quote:

acetaminophen is taken chronically throughout pregnancy to childbirth

Nobody should be doing this chronically
Posted by TigerDoc
Texas
Member since Apr 2004
11532 posts
Posted on 9/24/25 at 12:35 pm to
You’re right that we can’t and won’t do a placebo trial on pregnant women but that’s not the only way medicine figures out cause and effect. Thalidomide, Vioxx, even smoking were all nailed down without randomized trials. The process involves multiple lines of evidence - epidemiology, case reports, lab studies, dose-response patterns, etc. until the picture is clear. That’s why the bar for saying causal harm is high, and why a single suggestive study isn’t enough to overturn decades of safe use.
Posted by SallysHuman
Lady Palmetto Bug
Member since Jan 2025
15290 posts
Posted on 9/24/25 at 12:35 pm to
quote:

This is one of those things that should have been put out in the normal course and scope of FDA activities


If it had... it would not have made news or raised awareness in the population of pregnant and soon to be pregnant mothers.

It isn't a bad thing that this information and these changes have garnered so much attention.

The fact that Trump was headlining it and made it over the top (Yes, it was certainly over the top) is the ONLY reason anyone in the regular world is even discussing it at all.

This post was edited on 9/24/25 at 12:36 pm
Posted by loogaroo
Welsh
Member since Dec 2005
39917 posts
Posted on 9/24/25 at 12:37 pm to
quote:

you people are absolutely insane.


And getting worse. They are collectively losing what little of their minds they have left.

The desperation is is comical to watch.
Posted by 4cubbies
Member since Sep 2008
59376 posts
Posted on 9/24/25 at 12:39 pm to
quote:

If it had... it would not have made news or raised awareness in the population of pregnant and soon to be pregnant mothers.


Thank you, St. Donald Trump! Because of him, pregnant women will now finally start consulting their doctors before they take medication!

Some might even seek pre-natal care! All thanks to Saint Don

It’s truly a miracle a single healthy baby was ever born before this week.
This post was edited on 9/24/25 at 12:42 pm
Posted by SallysHuman
Lady Palmetto Bug
Member since Jan 2025
15290 posts
Posted on 9/24/25 at 12:40 pm to
quote:

Thank you, St. Donald Trump! Because of him, pregnant women will now finally start consulting their doctors before they take medication!


Hey, if it saves one life!
Posted by TigerDoc
Texas
Member since Apr 2004
11532 posts
Posted on 9/24/25 at 12:40 pm to
This is right on. Most real safety updates come through drug labeling changes or medical society guidance. They’re boring by design - because they’re meant to inform doctors, not capture news cycles. When it’s rolled out like breaking news, it warps how the public hears it.
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