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Interesting potentially therapeutic Covid inhibitor/treatment. Share with your doctor.

Posted on 1/3/22 at 4:15 pm
Posted by HubbaBubba
North of DFW, TX
Member since Oct 2010
51880 posts
Posted on 1/3/22 at 4:15 pm
I'd developed an allergy causing asthma-like symptoms and had a cough since early July, with the cough caused by sinus drip. I went to my doctor about it in December. I had been using OTC NasaCort to no real success. He gave me a prescription for Azelastine HCL 0.15% which is a nasal spray.

I wanted to learn more about it, and found THIS LINK to an article from last year showing this was already tested as a SARS-Cov2 inhibitor to very good success.

quote:

The results showed that azelastine significantly reduced cytopathic effect and inhibited SARS-CoV-2 infection of Vero E6 cells both in preventive and treatment settings. They also tested a 5-fold dilution of azelastine in a commercially available nasal spray. They found that it was very potent in inhibiting the propagation of the SARS-CoV-2 virus in infected human nasal tissue. The team concluded that the antihistamine azelastine might be considered for use in topical prevention or treatment of SARS-CoV-2 nasal colonization.

According to the team, azelastine, as such, could be helpful in reducing viral transmission and prophylaxis of COVID-19. However, the potential benefits of the drug needs to be proven in further clinical studies.
On my medical plan, this cost me $5 a month, which explains why maybe this is not being studied by the CDC as a potential therapeutic treatment. It costs too little.

Here is an image of 6 culture slides:



Slides:
A: uninfected (negative) control,
B: virus infected (positive) control,
C: virus + 3·125 µM azelastine,
D: virus + 6·25 µM azelastine,
E: virus + 12·5 µM azelastine,
F: virus + 25 µM azelastine.

The Full Study on using Azelastine nasal spray against SARS-Cov2 is found here.

Why hasn't this study been used to determine effectiveness against Covid-19 and Omicron? Covid-19 is caused by SARS-Cov2.
Posted by Bass Tiger
Member since Oct 2014
55739 posts
Posted on 1/3/22 at 4:22 pm to
Betadine nasal spray is Dr McCullough’s suggestion….pretty cheap too.
Posted by Slingin Pickle
Fancy side of the North Shore
Member since Jun 2008
3043 posts
Posted on 1/3/22 at 4:24 pm to
quote:

Why hasn't this study been used to determine effectiveness against Covid-19 and Omicron?


Because there is no money in that
Posted by HubbaBubba
North of DFW, TX
Member since Oct 2010
51880 posts
Posted on 1/3/22 at 4:45 pm to
quote:

Betadine nasal spray is Dr McCullough’s suggesti
No. There's no such actual studies this works and I ain't spraying betadine up my nose or gargling with it, either.
Posted by Aubie Spr96
lolwut?
Member since Dec 2009
44421 posts
Posted on 1/3/22 at 4:58 pm to
quote:

There's no such actual studies this works



There are. Listen to his interview on Joe Rogan. He cites them.

quote:

I ain't spraying betadine up my nose or gargling with it, either.


It’s a solution. You can buy it commercially.
Posted by 2 Jugs
Saint Amant
Member since Feb 2018
2358 posts
Posted on 1/3/22 at 5:22 pm to
I use Azelastine daily along with Flonase. Caught the virus at the end of July. Although I didn't get tested for the flu, I think that I had it also and that is what made me feel like shite for 2 weeks.
Posted by GumboPot
Member since Mar 2009
140573 posts
Posted on 1/3/22 at 5:25 pm to
quote:

Why hasn't this study been used to determine effectiveness against Covid-19 and Omicron? Covid-19 is caused by SARS-Cov2.



Only social distancing, mask and vaccines are allowed. No early treatment allowed.

Signed, Government, Medical Establishment, MSM, Big Pharma and Mask Covidians.
Posted by the808bass
The Lou
Member since Oct 2012
128797 posts
Posted on 1/3/22 at 5:26 pm to
quote:

There's no such actual studies this works and I ain't spraying betadine up my nose or gargling with it, either.


LINK
Posted by Bass Tiger
Member since Oct 2014
55739 posts
Posted on 1/3/22 at 7:16 pm to
quote:

Betadine nasal spray is Dr McCullough’s suggestion


No. There's no such actual studies this works and I ain't spraying betadine up my nose or gargling with it, either.


I’ve never tried Betadine nasal spray but it you Google betadine nasal spray it seems to be a pretty common nasal spray. I’ve never heard of gargling with betadine?
Posted by the808bass
The Lou
Member since Oct 2012
128797 posts
Posted on 1/3/22 at 7:19 pm to
McCullough recommended it on the Rogan podcast to reduce viral load in the upper respiratory system early on In hopes that the progression of the disease would be more mild.
Posted by Lou the Jew from LSU
Member since Oct 2006
5418 posts
Posted on 1/3/22 at 8:51 pm to
I’ve now heard of 3 therapeutics for Covid that I already use for other conditions:
Acyclovir (valtrex)- anti viral I take for cold sores
Famitodine (sic) that I take for cholesterol
and now azelistine for sinus.
We’ll see what happens, eh?
Posted by SmackoverHawg
Member since Oct 2011
31608 posts
Posted on 1/3/22 at 9:06 pm to
Has it been compared to saline nasal flushes? Perhaps the benefit is from diluting out the virus with the spray? It is a nasal antihistamine. I used it when I had it, but to help sneezing.
Posted by SmackoverHawg
Member since Oct 2011
31608 posts
Posted on 1/3/22 at 9:07 pm to
quote:

Acyclovir (valtrex)- anti viral I take for cold sores

acyclovir not the same as valtrex but either may convey some benefit. Certainly won't hurt if you're already on it.
Posted by Hopeful Doc
Member since Sep 2010
15388 posts
Posted on 1/3/22 at 11:34 pm to
quote:

Has it been compared to saline nasal flushes?



I wish I could convince everyone to do high-volume nasal/sinus flush/rinse (neti pot, et al).




That said, I usually reach for nasal atrovoent 0.06% for acute illnesses over astelin because it doesn’t leave this weird, bitter-metallic aftertaste, and I’m not totally convinced that nasal antihistamines add a ton of benefit over oral antihistamines which are so easy to come by.
Posted by roadGator
DeBoar’s dome
Member since Feb 2009
157846 posts
Posted on 1/3/22 at 11:36 pm to
quote:

wish I could convince everyone to do high-volume nasal/sinus flush/rinse (neti pot, et al).


How often and what solution?
Posted by Hopeful Doc
Member since Sep 2010
15388 posts
Posted on 1/4/22 at 12:00 am to
quote:

How often and what solution?



Most devices you’ll buy will come with a solution (in dry packets) that is something around 2:1 salt:baking soda- these are fine.


Any water you ever put in your nose should be distilled or brought to a rolling boil by you for >2 minutes. Not tap. Not filtered. Not bottled. Not anything other than distilled or boiled (and set to cool, which takes forever to get to a temperature that my nose can tolerate).

Then you pick one of two ways to do it:
Mix roughly 2:1 ratio of salt (the finer ground the better) to baking soda, and drop about 1/2-1 teaspoon per 8oz of water, or just go ahead and drop 8-16tsp in your gallon jug, store in the fridge, and shake well before filling up your vessel.

The mixture isn’t particularly magic. You want it hypertonic (pulls swelling/inflammation out of the tissue) but you don’t want it to burn (the higher the salt content, the more uncomfortable some noses find it). The real “magic” is the volume and rinsing the crap that builds up when you are sick out and get things moving.




When I said I wish “everyone” did this, I realize it may be misconstrued:
1) I wish all my seasonal allergy patients did this. I’ve had people on 1-2 pills and 2-3 nose sprays drop to 0-1 total medicines to keep it under control.
2) I wish most people when they did get a cold would do this- it’s probably as/more effective than most medicines for acute relief of stuffiness. COVID would fall into this category. Is there benefit to “washing off” excess virus in the mucosa? Certainly won’t hurt. Symptomatic relief is pretty wonderful, though, and probably the most difficult thing to treat with COVID is the splitting frontal sinus headache.
There’s no real “maximum” dose to this - I would do it twice a day while sick, more if it helps but the symptoms return.
If using Flonase (buy generic fluticasone from Amazon, Costco (Kirkland, Aller-flo) or Sams for great prices), astelin, or Atrovent, I would rinse and then use the spray more or less immediately after. I find it helps with the distribution of the spray to have a “clean” passage to get into.


But if someone told me that I had one non-antibiotic medication to treat the most nose symptoms, I would choose Atrovent. My partner would choose astelin. Both are good. I often offer both and say “would you rather a nose spray that’s twice a day with a bad taste or three times a day with a not great taste?”
Nothing about astelin should be “virocidal,” if such a thing exists. If it has any meaningful reduction in symptoms, i would postulate that it dries up the snot and irritated membranes that make it easier for virus to enter the mucosa and ruin the more “hospitable” environment for replication, and because of that, I would probably take this approach instead (thus my long explanation about regular allergy symptoms and colds).
Posted by supatigah
CEO of the Keith Hernandez Fan Club
Member since Mar 2004
90063 posts
Posted on 1/4/22 at 12:04 am to
HCL is a bacteria killer

nasal spray and a good mouthwash and you are golden
Posted by RockyMtnTigerWDE
War Damn Eagle Dad!
Member since Oct 2010
108979 posts
Posted on 1/4/22 at 12:24 am to
What are your thoughts on the Navagw device. I hear that commercial a lot?
Posted by Hopeful Doc
Member since Sep 2010
15388 posts
Posted on 1/4/22 at 12:31 am to
It’s $100
A neti pot is around $10-15. There are squeeze bottles around the price of a neti pot.


Start with the cheap one. If it works well for you, and you like it, consider spending $100 of you think this will become a regular part of your healthcare and have that to throw around.


I only know one person who has gone out and bought a navage. They sing its praises. Most people that I can convince to try a rinse either try one of the cheap options and it works (so why spend $100?) or it doesn’t (so why spend $100 to rinse in a different way).

The one “success” story did say they like the way it “pulls” the water back out the other side. But they think it works “better” than a neti pot. Not that it didn’t work, so they went with a navage.


I’m part of a Facebook group of guys that sort of reads like the OT Lounge. There’s an ENT or two that are either personally working on/invested in or just excited about a newer device that is basically a long-armed (~4” or so) pencil-sized tube that you stick in your nose and rinse with, and you’re supposed to be able to manipulate the wand. It should be on the “cheap” side of things, but I don’t remember the name, haven’t really seen/used it, and , again, sort of like what’s already out there on the cheap.
Posted by RockyMtnTigerWDE
War Damn Eagle Dad!
Member since Oct 2010
108979 posts
Posted on 1/4/22 at 12:34 am to
Thank you for all your great info. I am one that should have been doing this for years and have been considering it. I am fed up with constant sinus issues and ready to comply. Thank you again.
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