re: New diabetes medications prove the OT wrong, obesity is not always a choice

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WeeWee


do you have any clue how the medicines work?

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Yes I am an MD. I know how semaglutide works.

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do you have any clue how the medicines work? you keep posting shite like its not as simple as eating less.....but thats exactly how these medicines work. If it wasnt as easy as eating less then they wouldnt work. and metabolism has been shown to only decrease when at extreme caloric restriction. what happens is NEAT(non exercise activity that causes thermogenesis aka moving around) decreases because people get tired easier on lower calories due to recovery suffering from being in a caloric deficit.

all the drugs in this class are forms of glp-1 receptor agonist that curbs appetite and controls insulin. It controls appetite by slowing gastric emptying, controlling hunger pains from insulin spikes, and suppression of the hormone ghrelin. This greatly reduces food noise.

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Semaglutide does work by slowing gastric emptying that is true.

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semaglutide lowers body weight by direct interaction with diverse GLP-1R populations and by directly and indirectly affecting the activity of neural pathways involved in food intake, reward, and energy expenditure.

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LINK

Semaglutide also prevents the metabolic adaptation that normally occurs with decreasing food intake. This keeps the metabolism up which allows for weight loss. Without semaglutide the metabolism in obese patients decreases to match calorie intake.

That is not all research is showing that semaglutide also does other things like altering gene expression.

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Fgfr1 levels remained unaffected by HFD feeding or semaglutide treatment (Figure 5a,b). HFD feeding increased Fgf21 expression level in eWAT while one-week semaglutide treatment did not cause a further increase (Figure 5c). Figure 5d shows that HFD challenge significantly repressed Acox1, Ehhadh, and Ppargc1a, but not Pdk4 expression levels. Seven-day semaglutide treatment partially restored HFD-induced alterations on these three genes. Furthermore, adipose tissue-specific genes including those that encode leptin (Lep), adiponectin (AdipoQ), and UCP1 (Ucp1), were significantly altered by HFD challenge. HFD challenge increased Lep level by nearly 26-fold, and such elevation was partially attenuated by one-week semaglutide treatment (reduced to ~6.5 folds).

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LINK

Semaglutide reverses or reduces the negative effects of a high fat diet on the liver.

So yes semaglutide slows gastric emptying and decreases food intake but it also does a lot more.

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BMI of 27. A little overweight but far from a fatass. A1C of 5.3% at my checkup last week and cholesterol was good too.


How old are you?

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Mid 30s.

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obesity is not always a choice

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eh. Cut way way back on eating , at the same time exercise more, get on keto, you’d be amazed how the weight comes off

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MD

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not a very smart one, prolly a GP

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Semaglutide also prevents the metabolic adaptation that normally occurs with decreasing food intake. This keeps the metabolism up which allows for weight loss. Without semaglutide the metabolism in obese patients decreases to match calorie intake.

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no it doesnt precent any metabolic adaptation. first off starvation mode and metabolic damage due to caloric deficit has been debunked completely. read the studies in this article and educate yourself please LINK

2nd that is not even what your link says

the truth is we burn less calories because NEAT decreases in a caloric deficit due to the bodies natural adaptation to want to conserve calories by lowering activity levels. but the body itself does not slow down. aka BMR remains constant, TDEE may go down if not conscience about activity levels. This one area that ketosis shines as people that are fat adapted and in a caloric deficit do not show the same decrease in neat as those on iso caloric.

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That is not all research is showing that semaglutide also does other things like altering gene expression.

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no there isnt as these medicine do not work like that. its like you dont know what a agonist or antagonist are.

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Semaglutide reverses or reduces the negative effects of a high fat diet on the liver.

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1 week study on rats. lets wait for more research first

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So yes semaglutide slows gastric emptying and decreases food intake but it also does a lot more.

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no shite i named the reasons it works.

trust me im about 1000 percent sure i know more about this then you do by your post. being a doctor doesnt mean you know how it works


and for the record i 1000% support the use of these drugs. your just not a good salesman of them

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They are being disciplined if they are doing what they report in their logs or being very disciplined in faking the logs. From my experience treating them most are not faking. It is much easier to fly to Mexico and have bariatric surgery than fake it and jump through the hoops here.

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oh but they get the surgery and suddenly cant physically eat as much and lose weight....but yea im sure the laws of thermodynamics dont work for them right?



look you dont have to make up bullshite about these things not being a choose for people to support the use of the medicine.

anyone on here who doesnt support this medicine is not thinking clearly, jealous or just plain fricking stupid.

but stop acting like it works for any other reason than it makes you eat less. same with the bariatric surgery, the stomach ballon thing and every other one out there.

its not like these drugs are like the beta 2 agonist like ephedra, clenbutrol, albutrol and raise metabolic rate. its not like that are uncoupling agents like DNP and that are not a stimulate like caffeine. they also dont increase t3 output or t3 to t4 conversion. so they dont affect metabolic rate.

they simply make you eat less. the glp are particularly good at it as its a 3 pronged attack and has negative feedback loop if you try and continue the same behaviors that got you fat in the first place.

but stop trying to act like the laws of thermodynamics dont apply to some people.

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Do you work in weight management? Do you talk to these people and see what they are forgetting?

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No but we have plenty of studies on this that prove my point

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Do I think that they are perfect at logging calories? No they are far from it but is that the reason why they are not losing weight? Unlikely.

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he has to be the most uniformed doctor in the history of the earth. I do not understand how he passed medical school. he sure as frick can not read research.

getting schooled by the H&F boys


and again FTR I 1 million percent support the use of these medicines.

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That is not the case with obese people. Their gene expression has altered their metabolism.

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no it has not!!! provide the studies or stfu. please.

there are atleast 20 meta analysis out showing this is not true dude

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Calorie restriction => decreased metabolism.

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not true...i sent you an article with over a dozen linked studies showing this is false

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Biology is not physics see above for further details.

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mr doctor is wrong again folks!!!

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don't believe this. At all. You can "verify" what is logged into the system, but I guarantee they're not being honest if no weight is lost.

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I agree. Just bc someone’s says they’ve been going to the gym doesn’t mean they’re putting in the effort needed to see results.

There’s tons of people who go to the gym just to say they went and while there do practically nothing

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I agree metabolism is different from person to person and it is not fair

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Right, and the whole “your fault/not your fault” dichotomy is not helpful.

Being honest and focusing on calorie intake vs expenditure is about educating people and solving the root of the problem, not about assigning blame.

Clouding the issue with discussion of genetics and lack of relative blame just reduces agency and gives people the excuse to continue to do what they already want to do.

Some people will take this drug for the rest of their lives and consequently eat less and thus lose weight, but the “it’s not your fault” message will be heard and taken to heart by everyone who is ill-informed.

These drugs should be an opportunity to drive home the true message and work to lessen overall unhealthy behavior even in those who don’t take the drug, but that’s not what is happening.

Also, judging by the one person I know who was given the shots, the drugs aren’t being given along with a requirement to show any lifestyle changes.