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Started By
Message
re: Long term SSRI use drawbacks
Posted on 10/1/25 at 5:01 pm to Jim Rockford
Posted on 10/1/25 at 5:01 pm to Jim Rockford
quote:
I've had some kickass dreams
The best part, in my opinion, of getting real quality sleep (via pharma, cpap, yoga...wtfever) is the dreams.
It's like you've been blocking up your subconscious for a bit with shitty sleep and it finally gets to dump when you hit REM.
Posted on 10/1/25 at 5:05 pm to GeneralLee
quote:
Those of you who got off SSRI’s
I committed to working with a therapist on a form of cognitive behavioral therapy. Once I was able to learn to manage my anxiety using those techniques, we discussed getting off the meds. My doctor was supportive and helped me taper off over several months.
Posted on 10/1/25 at 5:10 pm to soccerfüt
quote:
Glad I’m not gay. I’m good at pleasing a woman.
quote:
soccerfüt
Remember when you claimed to make over $650k a year
I member
Posted on 10/1/25 at 5:14 pm to GeneralLee
Try every other day dosing for awhile.. L tryptophan 1 gram a night helps boost serotonin levels and is a great supplement to add on. Omega 3 supplement as well
Posted on 10/1/25 at 5:34 pm to GeneralLee
From a doctors perspective, if you’re on SSRI/SSRIs for longer than 6 to 12 weeks, and especially at higher dosages, you should always wean off over a long period of time, depending on a few things. For you using sertraline, that’s one of the harder ones to get off of especially when you try to do a cold turkey.
If you were on 100 mg the smoothest way would be to drop it down by 25% a month and then once you’re down to 25 mg go to every other day and see how you feel. If you’re even having trouble then you can always ask your doctor for a short course of trazodone or BuSpar to take the edge off.
If you were on 100 mg the smoothest way would be to drop it down by 25% a month and then once you’re down to 25 mg go to every other day and see how you feel. If you’re even having trouble then you can always ask your doctor for a short course of trazodone or BuSpar to take the edge off.
Posted on 10/1/25 at 5:57 pm to GeneralLee
I am a MH professional (but not your MH professional). The following is not advice, medical or otherwise. It is a ln off the cuff response to a hypothetical situation.
Someone taking 100 mg/day of Sertraline would be on a moderate dose. The maintenance range goes up to 200mg/day. Sertraline is also one of the SSRIs most likely to cause discontinuation syndrome. Symptoms may include flu like symptoms, depressive feelings, anxiety, sleep disturbance, and “brain zaps” (like static electricity discharging in your brain. Those symptoms will abate, but it can take months sometimes.
The way to minimize discontinuation syndrome is to slowly taper off. Do this in conjunction with your prescriber. Don’t do it on your own without them knowing and supporting you. There’s a few different schedules that have been mentioned here and all seem reasonable. Better to take it slow and be successful than to go too quick and suffer.
Some things I would tell someone to incorporate: regular sleep schedule aiming for 7-8 hours per day; exercise- lifting weights is great for mood; sunlight- walking outdoors is good; healthy diet- nothing drastic needed, but try to eat “real” whole foods as much as possible; keep up with your social life and do things with people.
And to address a couple other comments- yes, depression is a sign that something is wrong in your life. That means you need to do something to address whatever is wrong. For lots of people that would probably best be addressed through therapy. For some people medication is needed. SSRIs are wonderful medicine when used judiciously. When used long term they can change your body’s natural processes and make discontinuing difficult. True long-term SSRI use should ideally be very rare. Most people should take them for a short time (a few months to a year or so) and plan for discontinuing or at least trying to. The key is to address the issues in your life that are contributing to your depression- especially those things that are inside you and your psyche as opposed to external situations that you may not have control over.
Someone taking 100 mg/day of Sertraline would be on a moderate dose. The maintenance range goes up to 200mg/day. Sertraline is also one of the SSRIs most likely to cause discontinuation syndrome. Symptoms may include flu like symptoms, depressive feelings, anxiety, sleep disturbance, and “brain zaps” (like static electricity discharging in your brain. Those symptoms will abate, but it can take months sometimes.
The way to minimize discontinuation syndrome is to slowly taper off. Do this in conjunction with your prescriber. Don’t do it on your own without them knowing and supporting you. There’s a few different schedules that have been mentioned here and all seem reasonable. Better to take it slow and be successful than to go too quick and suffer.
Some things I would tell someone to incorporate: regular sleep schedule aiming for 7-8 hours per day; exercise- lifting weights is great for mood; sunlight- walking outdoors is good; healthy diet- nothing drastic needed, but try to eat “real” whole foods as much as possible; keep up with your social life and do things with people.
And to address a couple other comments- yes, depression is a sign that something is wrong in your life. That means you need to do something to address whatever is wrong. For lots of people that would probably best be addressed through therapy. For some people medication is needed. SSRIs are wonderful medicine when used judiciously. When used long term they can change your body’s natural processes and make discontinuing difficult. True long-term SSRI use should ideally be very rare. Most people should take them for a short time (a few months to a year or so) and plan for discontinuing or at least trying to. The key is to address the issues in your life that are contributing to your depression- especially those things that are inside you and your psyche as opposed to external situations that you may not have control over.
Posted on 10/1/25 at 6:09 pm to Mingo Was His NameO
quote:So you decide to call out an anonymous stranger on the internet over an issue that really can’t be proven or disproven here. (W-2s, K-1s, 1040s can be easily forged)
Remember when you claimed to make over $650k a year
You are your typical ignorant and unwise self to attempt to call me out on this.
I know for sure at least one of us has never made $650k in a year.
Posted on 10/1/25 at 6:19 pm to soccerfüt
quote:
So you decide to call out an anonymous stranger on the internet over an issue that really can’t be proven or disproven here.
You claimed to have been in the highest tax bracket for the last 30 years. It’s pretty simple, just don’t lie, not get mad at me for calling you out on it
Posted on 10/1/25 at 6:33 pm to GeneralLee
I came off those cold turkey after being on them for over a year. It was absolute hell and is why I will never touch them again. They definitely need to be weened off of and I do not recommend going cold turkey off them.
Posted on 10/1/25 at 6:38 pm to Mingo Was His NameO
quote:Guilty.
You claimed to have been in the highest tax bracket for the last 30 years
Married filing Jointly.
I’m heterosexual.
We’ve been able to do this for 3 decades
Posted on 10/1/25 at 6:40 pm to The Pirate King
quote:
Your prescribing physician or any family doctor should be able to walk you through the weaning process
Prescribing physician describes them best. Most don’t know shite beyond that
Posted on 10/1/25 at 9:35 pm to Howyouluhdat
Many doctors only know how to get you on ssri and don’t have a clue about tapering dosage for long-term users. For anyone on lexipro generic, you can get it in liquid form. This is the way to go versus splitting pills, especially if you are tapering say 10% at a time. Have you ever tried to cut a pill precisely from 10mg to 9mg?
Everyone is different, but if you are unfortunately a long-term user (>20 yrs), it could take several years to come completely off according to a psychiatric doctor named Josef Witt-Doerring (taperclinic.com) who specializes in ssri and benzo tapering. I highly recommend you visit his website and watch his videos if you are currently tapering or thinking about it.
Everyone is different, but if you are unfortunately a long-term user (>20 yrs), it could take several years to come completely off according to a psychiatric doctor named Josef Witt-Doerring (taperclinic.com) who specializes in ssri and benzo tapering. I highly recommend you visit his website and watch his videos if you are currently tapering or thinking about it.
Posted on 10/1/25 at 9:41 pm to GeneralLee
Hey man FWIW, I’m glad you made it through whatever it was that you were going through. Happy for you that you’re also trying to get off the medication. Keep fighting bro 
Posted on 10/1/25 at 9:59 pm to GeneralLee
I cold turkeyed it was a PIA for about 10 days. Headaches & moody but I’m so much clearer now it a huge blessing.
Posted on 10/1/25 at 10:33 pm to el Gaucho
Yep. Red wine for me. Sleep ain't great without it.
Oh, and OP, sorry for whatever you were going through. Last year, out of the blue, I had a multi week episode of no sleep and awful anxiety. Long term stress maybe. It was god awful and I was wrecked. Had a hard time working. Better today. But mental breaks are no joke. Red wine got me through it.
Oh, and OP, sorry for whatever you were going through. Last year, out of the blue, I had a multi week episode of no sleep and awful anxiety. Long term stress maybe. It was god awful and I was wrecked. Had a hard time working. Better today. But mental breaks are no joke. Red wine got me through it.
This post was edited on 10/1/25 at 10:36 pm
Posted on 10/1/25 at 10:41 pm to GeneralLee
quote:
Those of you who got off SSRI’s, did you just have to power through this phase and things got better? Or did you give up and just go back on them? Thanks.
Whatever you do, make sure you discuss it with your doctor. They can probably make this easier and safer for you if you inquire about it.
Posted on 10/2/25 at 12:31 am to TigerBait1971
What dosage? I feel like I’m in the same boat right now with Lexapro.
Posted on 10/2/25 at 6:39 am to GeneralLee
Used to take Zoloft. Got in the gym. No longer on it!
Posted on 10/2/25 at 8:32 am to GeneralLee
Thought this thread was about Social Security. God I'm old.
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