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Started By
Message
When fasting, when does your body begin ketoisis?
Posted on 7/21/18 at 9:15 am
Posted on 7/21/18 at 9:15 am
Wondering if fasting for 24 hours will begin ketoisis or not.
I would like to attempt OMAD, but want to stay away from ketoisis.
I would like to attempt OMAD, but want to stay away from ketoisis.
Posted on 7/21/18 at 9:23 am to Lookin4Par
Lots of factors but if you were on a standard American diet prior to starting your fast, then probably not. It’ll take 2-3 days without exercise.
Posted on 7/21/18 at 10:01 am to Lookin4Par
Depends on what you ate before.
Posted on 7/21/18 at 10:30 am to lsu777
I’m going to keep moderate (good) carbs. No added sugars and limiting sugars from fruits/veg. Higher protein and fats.
Posted on 7/21/18 at 10:48 am to Lookin4Par
Why exactly do you want to "avoid ketosis"? And what are your goals in fasting?
Your liver makes ketones even if you aren't doing things like prolonged fasting or following a fast-mimmicking diet.
If you are breaking your normal overnight fasts with sugar or high protein then that process slows to a halt and you continue burning glucose and storing glycogen.
If you continue a fast and/or eat high-fat, low-carb, moderate protein (and the ratios vary by individual of course), then your liver will keep making ketones and your body will adapt to that fuel source.
Beta-hydroxybutyrate is an incredible energy source and doesn't require insulin to get to your mitochondria. It has been proven to defeat harmful inflammasomes.
I understand people being afraid of fat (as irrational as that may be), but I don't understand a blanket aversion to using ketones as fuel (as in, even if you aren't actively trying to get "into ketosis," why would you actively desire to avoid it as a side effect of fasting?).
Your liver makes ketones even if you aren't doing things like prolonged fasting or following a fast-mimmicking diet.
If you are breaking your normal overnight fasts with sugar or high protein then that process slows to a halt and you continue burning glucose and storing glycogen.
If you continue a fast and/or eat high-fat, low-carb, moderate protein (and the ratios vary by individual of course), then your liver will keep making ketones and your body will adapt to that fuel source.
Beta-hydroxybutyrate is an incredible energy source and doesn't require insulin to get to your mitochondria. It has been proven to defeat harmful inflammasomes.
I understand people being afraid of fat (as irrational as that may be), but I don't understand a blanket aversion to using ketones as fuel (as in, even if you aren't actively trying to get "into ketosis," why would you actively desire to avoid it as a side effect of fasting?).
This post was edited on 7/21/18 at 10:50 am
Posted on 7/21/18 at 10:51 am to McLemore
I’ve had great success with Keto in the past, but cannot maintain it for long periods of time. Going in and out of Keto weekly or bi-weekly wreaks havoc on my bodies ability to flush uric acid, inducing gout attacks.
This post was edited on 7/21/18 at 10:54 am
Posted on 7/21/18 at 10:55 am to McLemore
Would like to utilize fasting (OMAD) to maximize autophagy and increase health, including the liver and kidneys ability to flush uric acid and other toxins.
Posted on 7/21/18 at 10:58 am to Lookin4Par
Gotcha. But ketones themselves don't cause or exacerbate gout.
In fact it's the exact opposite. The inflammasome NLRP3 contributes to gout swelling, and beta-hydroxybutyrate is the sworn enemy of that neutrophil-inflammasome.
2017 study pub
It's other stuff in an improperly formulated and/or executed "ketogenic" diet and/or other lifestyle issues.
Also, If you start feeling gout effects, you could "refeed" with cherries.
I'm not pushing keto on you, but I would research more on the keto-gout connection.
Ahhh the old science downvoter on this board. Explain your downvote.
In fact it's the exact opposite. The inflammasome NLRP3 contributes to gout swelling, and beta-hydroxybutyrate is the sworn enemy of that neutrophil-inflammasome.
2017 study pub
It's other stuff in an improperly formulated and/or executed "ketogenic" diet and/or other lifestyle issues.
Also, If you start feeling gout effects, you could "refeed" with cherries.
I'm not pushing keto on you, but I would research more on the keto-gout connection.
Ahhh the old science downvoter on this board. Explain your downvote.
This post was edited on 7/21/18 at 11:03 am
Posted on 7/21/18 at 11:02 am to McLemore
quote:
I'm not pushing keto on you
quote:
by McLemore
Lol
Posted on 7/21/18 at 11:03 am to Mingo Was His NameO
Thanks for exposing yourself as the science downvoter. Explain how ketones in and of themselves cause or exacerbate gout. Thanks.
Start here, perhaps--this is from the intro to the pub I linked above. Debunk away:
Start here, perhaps--this is from the intro to the pub I linked above. Debunk away:
quote:
Aging and lipotoxicity are two major risk factors for gout that are linked by the activation of the NLRP3 inflammasome. Neutrophil-mediated production of interleukin-1ß (IL-1ß) drives gouty flares that cause joint destruction, intense pain, and fever. However, metabolites that impact neutrophilinflammasome remain unknown. Here, we identified that ketogenic diet (KD) increases ß-hydroxybutyrate (BHB) and alleviates uratecrystal-induced gout without impairing immune defense against bacterial infection. BHB inhibited NLRP3 inflammasome in S100A9 fibril-primed and urate crystal-activated macrophages, which serve to recruit inflammatory neutrophils in joints. Consistent with reduced gouty flares in rats fed a ketogenic diet, BHB blocked IL-1ß in neutrophils in a NLRP3-dependent manner in mice and humans irrespective of age. Mechanistically, BHB inhibited the NLRP3 inflammasome in neutrophils by reducing priming and assembly steps. Collectively, our studies show that BHB, a known alternate metabolic fuel, is also an anti-inflammatorymolecule that may serve as a treatment for gout.
This post was edited on 7/21/18 at 11:06 am
Posted on 7/21/18 at 11:09 am to McLemore
My understanding is that with reduced kidney function, ketones compete with uric acid to flush out.
Posted on 7/21/18 at 11:14 am to Lookin4Par
The uric acide rise has been shown to completely dissipate once keto adapted--2-3 weeks.
But if you don't want to go through that process, while still on OMAD, I guess you'll have to self-experiment with what ketone level (you're going to produce some ketones on OMAD, especially if you move at all) causes a uric acid rise to the gouty level.
I've never had this issue, so I have no n=1 in this regard.
ETA: also if you want to do OMAD and actually get over the uric acid hump, then you could temporarily use allopurinol. It's hard to find a doctor who cares and knows enough about nutrition to help you formulate all this.
Dr Phinney is an MD/PhD who focuses a lot on the adaptation phase.
Good read/listen, and this was 7 years ago. I'm sure he's refined and developee this further:
Phinney on Gout and uric acid
Excerpt from intro:
And to Mingo--i am in no way pushing a ketogenic diet. I'm addressing the inevitable ketone production in an OMAD diet (with any physical activity).
But if you don't want to go through that process, while still on OMAD, I guess you'll have to self-experiment with what ketone level (you're going to produce some ketones on OMAD, especially if you move at all) causes a uric acid rise to the gouty level.
I've never had this issue, so I have no n=1 in this regard.
ETA: also if you want to do OMAD and actually get over the uric acid hump, then you could temporarily use allopurinol. It's hard to find a doctor who cares and knows enough about nutrition to help you formulate all this.
Dr Phinney is an MD/PhD who focuses a lot on the adaptation phase.
Good read/listen, and this was 7 years ago. I'm sure he's refined and developee this further:
Phinney on Gout and uric acid
Excerpt from intro:
quote:
As an overview, most medical professionals consider higher uric acid levels to be a sign of danger, and that’s one reason that many warn that a low carb, high-fat diet is a bad idea–because at least at first, transitioning to a high-fat, low-carb diet raises uric acid levels in the blood. But as you’ll see in this discussion, Steve Phinney, who’s an expert on long-term adaptation to high fat diets, can demonstrate that a short-term rise of uric acid is not hazardous for most people, and if someone stays on a low carb diet over time, uric acid levels go down. Currently, it’s also commonplace among medical professionals to say that ketones are bad for health. Ketones are are a type of fat produced when the body is burning lots of fat, and when the body creates ketones, it’s often possible to detect them through urine or blood tests. Many health professionals assume that detectable ketone levels are always a warning sign of ketoacidosis, but that’s not true. Ketoacidosis IS dangerous, but it generally only happens when blood sugar levels are high at the same time ketones are going very high. When blood sugar levels are normal, many experts on low-carb diets report that the presence of ketone bodies in the blood or urine can be an indication that a body is “keto-adapted.” That is, a keto-adapted person’s body may be in a very healthy state that involves burning fats for fuel. It’s worth noting that many conventional health experts still disagree with this opinion.
So, who’s right? And what’s the right thing to do for health? That’s what these two scientists will discuss.
And to Mingo--i am in no way pushing a ketogenic diet. I'm addressing the inevitable ketone production in an OMAD diet (with any physical activity).
This post was edited on 7/21/18 at 11:25 am
Posted on 7/21/18 at 11:30 am to McLemore
Appreciate the feedback and resources.
I’m a fan of Dr Fung and his perspective on IF and Keto.
I’m a fan of Dr Fung and his perspective on IF and Keto.
Posted on 7/21/18 at 11:50 am to Lookin4Par
You will not enter ketosis as long as you keep your glycogen stores full. Once glycogen stores are depleted gluconeogenesis takes over to provide the body with energy.
GOUT - Water is your friend, drink it, a lot.
“including the liver and kidneys ability to flush uric acid and other toxins.”
Here is a product that is great and works (no affiliation with the company)
LINK
I think it is imperative to keep liver glycogen full if you are training and hovering on the edge of ketosis. Apart from the health benefits, you will lose that shitty feeling you are talking about on prolonged ketogenic diets. Best way to make sure your liver glycogen is regulating is post workout fructose. I am assuming your OMAD is post workout???? you could afford some starchy carbs as well and could take Berberine or Metformin 500 to make better use of those PWO carbs.
GOUT - Water is your friend, drink it, a lot.
“including the liver and kidneys ability to flush uric acid and other toxins.”
Here is a product that is great and works (no affiliation with the company)
LINK
I think it is imperative to keep liver glycogen full if you are training and hovering on the edge of ketosis. Apart from the health benefits, you will lose that shitty feeling you are talking about on prolonged ketogenic diets. Best way to make sure your liver glycogen is regulating is post workout fructose. I am assuming your OMAD is post workout???? you could afford some starchy carbs as well and could take Berberine or Metformin 500 to make better use of those PWO carbs.
This post was edited on 7/21/18 at 11:55 am
Posted on 7/21/18 at 6:20 pm to Lookin4Par
quote:
I’m a fan of Dr Fung and his perspective on IF and Keto.
He's good. I listened to his latest Rhonda Patrick podcast episode (Found My Fitness podcast). They nerd out a bit much and put me to sleep a couple times, but good stuff.
That uric acid one I posted was interesting--i am going to look for updated research tonight.
It's probably the most tangible (literally palpable) known acute issue with nutritional ketosis (whether through food choice or fasting). The keto flu is easily avoided. Getting through gout and kidney stones is more complex and obviously more painful.
Posted on 7/21/18 at 7:10 pm to Lookin4Par
quote:What does this mean?
(good) carbs
Posted on 7/21/18 at 9:26 pm to Big Scrub TX
For me it means minimally processed carbs without fructose and minimal total sugar.
...
potato’s
Rice
Sweet tater
Some pasta
Lentils
Beans
...
potato’s
Rice
Sweet tater
Some pasta
Lentils
Beans
Posted on 7/22/18 at 12:24 am to Lookin4Par
quote:
Would like to utilize fasting (OMAD) to maximize autophagy and increase health, including the liver and kidneys ability to flush uric acid and other toxins.
If these are truly your goals, you need to be in ketosis to make it happen. Sorry, but for these goals you are just wasting g your time and the fast otherwise. Also need to think long and hard about trying to extend the fast to 72 hours twice weekly.
If gout is your worry, look up snake juice kidney shots. Take it 2-3 times if doing omad. Also time of water to flush the toxins out.
Posted on 7/23/18 at 11:17 am to lsu777
Peter Attia is a great follow on all things keto, has a new podcast too. He has Dom D'Agostino on episode 5. Haven't gotten a chance to listen to it yet though.
He just did a one week fast and has a bunch of the numbers up on his instagram.
https://peterattiamd.com/
https://twitter.com/PeterAttiaMD
He just did a one week fast and has a bunch of the numbers up on his instagram.
https://peterattiamd.com/
https://twitter.com/PeterAttiaMD
Posted on 7/23/18 at 11:25 am to Kingpenm3
This post was edited on 7/23/18 at 11:26 am
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