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re: New cholesterol treatment can cut levels by 69% after one dose

Posted on 7/14/25 at 7:59 am to
Posted by Lakeboy7
New Orleans
Member since Jul 2011
28324 posts
Posted on 7/14/25 at 7:59 am to
quote:

at best taking them for years extends your life by a few days




Oh man you comin with the hard science now.
Posted by scottydoesntknow
Member since Nov 2023
10870 posts
Posted on 7/14/25 at 9:11 am to
A drug that inhibits an essential and natural process...seems like bad idea
Posted by LSUA 75
Colfax,La.
Member since Jan 2019
4961 posts
Posted on 7/14/25 at 10:38 am to
“There are so many conflicting opinions on this one I don’t know what to believe)

The value of statins is way overblown except for those with known cardio-vascular diseases and genetic hypercholesteremia.

Drug companies,write the guidelines,and use their financial influence with American College of Cardiology and American Heart Association to push them.Also,have lowered the levels recommended to treat.
One way they influence Drs,is they use a statistical trick-they report benefit as relative risk reduction,much more honest is to use absolute risk reduction and number needed to treat.
Relative risk reduction makes benefit look much better than it actually is.
Ex. if 100 people are treated for 5 years and there is 1 death compared to placebo group with 2 deaths RRD would be 50%.ABR not nearly as high.
Of much greater harm is smoking,excessive refined sugar and simple carbs,lack of exercise.
There are some unfortunate people with inherited high lipoprotein a,their risk is higher no matter what they do.There are drugs being developed to treat that.
Posted by LSUA 75
Colfax,La.
Member since Jan 2019
4961 posts
Posted on 7/14/25 at 12:21 pm to
I read a quote by Harry Loynd,once President and CEO of Parke -Davis drug company-“If we put horse manure in a capsule,we could sell it to 95 percent of these doctors “

Funny but not funny.

This was in the 60’s,after the Covid debacle I’m pretty sure it’s still true.
,
Posted by Jax Teller
Member since Aug 2018
4666 posts
Posted on 7/15/25 at 8:02 am to
quote:

69%


Posted by Reubaltaich
A nation under duress
Member since Jun 2006
5550 posts
Posted on 7/21/25 at 5:36 am to
quote:

And what is the myth?


Most likely this:

LINK
Posted by ole man
Baton Rouge
Member since Nov 2007
18059 posts
Posted on 7/25/25 at 8:13 am to
[quote]The FDA food pyramid is BS. 60%+ of carbohydrates in American's diets is what's killing people, not cholesterol. Cholesterol is trying to fight that garbage diet.
[/quot

You sir are 100% correct
Posted by CamdenTiger
Member since Aug 2009
65812 posts
Posted on 7/26/25 at 5:16 am to
Cholesterol is needed, for almost everything. It make up your cell walls, spackles and repairs heart disease, and creates the resistance for nerve conduction, and prevents that from causing dementia. It’s also necessary for hormone production like estrogen/testosterone. We need high LDL’s, regardless what your doctor says, as we age.
There are hyperlipidemias that justify the use of statins, but those are rare, most people should not be on one, period!
Posted by Rize
Spring Texas
Member since Sep 2011
19393 posts
Posted on 7/26/25 at 12:14 pm to
quote:

Cholesterol is needed, for almost everything. It make up your cell walls, spackles and repairs heart disease, and creates the resistance for nerve conduction, and prevents that from causing dementia. It’s also necessary for hormone production like estrogen/testosterone. We need high LDL’s, regardless what your doctor says, as we age. There are hyperlipidemias that justify the use of statins, but those are rare, most people should not be on one, period!


I’ve been on a statin for cholesterol for about 3 or 4 years now. My numbers were really bad a year ago while still on them. I was eating like shite and drinking too much. Change my diet and saw improvement but nothing drastic.

These were my numbers a year ago on the left and my number this week on the right.

Cholesterol level 231 133
Triglyceride level 508 75
HDL Level 33 38
Total cholesterol /HDL ratio 7 calc 3.5 calc
Non HDL level 198 95

Numbers 6 months ago with way less drinking and eating better were still above normal but not as high. The biggest change was I got on TRT 90 days ago and now all my shite is in range expect I need to get my HDL up 2 points to 40 to be in normal range.

I’ve always worked out for the past 25 years but went from 3 to 4 days a week to 5. The last few months. I did notice when I went on the statin I seemed to have gotten weaker in the gym a few years ago.

I’m going to get with my doc and tell her I would like to get off the statin asap.

2 years ago I was 6’1 215 muscular build, year ago around 200 and this week I was 6’1 186 still muscular but much slimmer. Trying to gain another 9 pounds to get back to around 195. That would put my morning weight around 190.
This post was edited on 7/26/25 at 12:35 pm
Posted by calcotron
Member since Nov 2007
10748 posts
Posted on 7/26/25 at 8:09 pm to
quote:

Triglyceride level 508 75


Holy shite, and thank goodness for your sake.
Posted by Rize
Spring Texas
Member since Sep 2011
19393 posts
Posted on 7/28/25 at 6:33 pm to
quote:

Holy shite, and thank goodness for your sake.


Yeah I was eating Mexican food like 4 days a week with a basket of those delicious chips

I also started taking Metamucil so not sure which one it was that knocked it down to 75 but maybe it was a combo. I brought it down to the 200’s by just diet alone but I’ve eaten clean before and never got it back into the good range ever. Was not until the TRT and Metamucil.
Posted by SlidellCajun
Slidell la
Member since May 2019
16423 posts
Posted on 9/17/25 at 9:41 pm to
Statins have side effects

There’s another alternative called Repatha which is an injection every few weeks. It’s not a statin. Very expensive.

None of these drugs will completely eliminate cholesterol so no need to worry about robbing the brain. It’ll still get plenty.
The drugs just reduce the amount to what is hopefully acceptable level to keep from artery blockage.

Anyone who wants to avoid the drugs should first get a calcium score. If the number is high, you need to rethink your decision to not take the meds. If your calcium score is good then you can probably be okay to just monitor things.

Dietary changes can help some but not everyone. Some of this is hereditary and dietary changes can help but not completely do the trick

And this is a sports message board so that this and all advice accordingly. The above info is what I experienced.
This post was edited on 9/18/25 at 7:40 am
Posted by Mingo Was His NameO
Brooklyn
Member since Mar 2016
37536 posts
Posted on 9/17/25 at 9:52 pm to
quote:

Dietary changes can help some but not everyone. Some of this is hereditary and dietary changes can help but not completely do the trick


Posted by TutHillTiger
Mississippi Alabama
Member since Sep 2010
49830 posts
Posted on 9/18/25 at 12:06 am to
Repatha does the same thing dropped mine from 220 to 7, that’s right 7. My triglycerides went from 345 to like 35 But it is twice a month

I lost 10 pounds was going to gym 4 to 5 times a week etc etc and my cholesterol dropped like 5 points and my cardiologist said “frick it, u did everything I ask you to do and the numbers barely moved, your problem is genetic. You are going on Repatha.
This post was edited on 9/18/25 at 12:13 am
Posted by SlidellCajun
Slidell la
Member since May 2019
16423 posts
Posted on 9/18/25 at 7:40 am to
Mingo, what exactly is so funny to you?
Posted by guedeaux
Member since Jan 2008
13862 posts
Posted on 9/18/25 at 10:50 am to
quote:

I lost 10 pounds was going to gym 4 to 5 times a week etc etc and my cholesterol dropped like 5 points and my cardiologist said “frick it, u did everything I ask you to do and the numbers barely moved, your problem is genetic. You are going on Repatha.


I had a similar experience. I went back to the cardiologist ready to wow them with my lower cholesterol after eating right, lifting weights 5-6 times/week, and losing 25 pounds in a year. Barely a noticeable difference in numbers. I got on a low dose statin, and now I am right in the middle of the normal range.

Posted by Mingo Was His NameO
Brooklyn
Member since Mar 2016
37536 posts
Posted on 9/18/25 at 11:27 am to
quote:

Mingo, what exactly is so funny to you?


Your inference that most people’s high cholesterol and hypertension is genetic and not due to the fact that they’re fat and out of shape
Posted by lsu777
Lake Charles
Member since Jan 2004
38079 posts
Posted on 9/18/25 at 12:42 pm to
quote:

Your inference that most people’s high cholesterol and hypertension is genetic and not due to the fact that they’re fat and out of shape


there are some that its genetic but you are correct in that its not close to most people. i would say maybe 10-15% of people...maybe 20% max
Posted by Fiddler crab
South in winter North in summer
Member since Jul 2024
155 posts
Posted on 9/18/25 at 3:12 pm to
quote:

There’s another alternative called Repatha which is an injection every few weeks. It’s not a statin. Very expensive

If you’re interested in Repatha, you might check out LEQVIO. Also very expensive but only two doses in the first six months and two annually after that. My cardiologist got it covered by insurance, but that was a long process requiring proof of statin intolerance.
Posted by SlidellCajun
Slidell la
Member since May 2019
16423 posts
Posted on 9/18/25 at 4:29 pm to
quote:

Your inference that most people’s high cholesterol and hypertension is genetic and not due to the fact that they’re fat and out of shape


Go back and read my post. I never said or even interred “‘most people”

And when it comes to “fat and out of shape” just to inform you and others, i know at least 5 people with high cholesterol and on meds and they’re thin and some are in excellent shape.

There’s just not many absolutes that I can find with respect to cholesterol
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