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re: New cholesterol treatment can cut levels by 69% after one dose

Posted on 9/21/25 at 8:51 am to
Posted by sharkfhin
Water
Member since Sep 2008
6341 posts
Posted on 9/21/25 at 8:51 am to
quote:

quote:
I lost 10 pounds was going to gym 4 to 5 times a week etc etc and my cholesterol dropped like 5 points and my cardiologist said “frick it, u did everything I ask you to do and the numbers barely moved, your problem is genetic. You are going on Repatha.


I had a similar experience. I went back to the cardiologist ready to wow them with my lower cholesterol after eating right, lifting weights 5-6 times/week, and losing 25 pounds in a year. Barely a noticeable difference in numbers. I got on a low dose statin, and now I am right in the middle of the normal range.
i am always around 200-300 on triglycerides sometimes lower and sometimes higher. My doctor told me he has several patients who run marathons and working out who are in great condition and shape and their scores are higher than mine. He said its genetic in alot of people too that no matter what they do, its up.

My issue with a statin is that I get bloated feeling and lots of pain up and down my body like I have a high fever. Sucks. So I dont take the statin(atorvastatin). Ive started a multivitamin with a omega 3 and quit eating some of the bad foods that contribute to higher triglycerides. Gonna find out in Feb when I do my annual.
This post was edited on 9/21/25 at 8:55 am
Posted by guedeaux
Member since Jan 2008
13862 posts
Posted on 9/21/25 at 9:50 am to
quote:

atorvastatin


That's the first one my doc put me on, and I had similar symptoms. Switched to rosuvastatin and haven't had any side effects.
Posted by Sho Nuff
Oahu
Member since Feb 2009
14033 posts
Posted on 9/22/25 at 4:31 pm to
Same. I'm on rosu 20mg. I really don't want to take statin though. I started taking Sports Research triple strength fish oil in July. I did blood work in early August, so I don't know if it really had time to start working. My numbers in the last year:
Oct 2024:
CHOL - 140
HDL - 61
LDL - 68
Triglyceride - 56

Aug 2025:
CHOL - 146
HDL - 63
LDL - 69
Triglyceride - 71

All to say I don't know wtf to do. My CHOL was as high as 235 when I wasn't taking a statin. Then I was on a low dose (10mg), and now I'm on double that. At minimum I think I'm going to ask about going on a low-dose again and keep up with the Omega-3.
Posted by Nole Man
Somewhere In Tennessee!
Member since May 2011
9120 posts
Posted on 9/30/25 at 10:23 am to
Had a similar discussion with wife (no pics).

We've both been on Atorvastatin for years. I haven't had any know side effects. She recently got off them, went to her cardiologist and decided she'd get a shot of Leqvio and begin the course of treatment over the next year. Concern was long-term safety, especially in older and possible risks such as cognitive effects (e.g., Alzheimer’s), muscle issues, or other relevant concerns.

Statins, such as Atorvastatin, remain the first-line therapy for lowering LDL cholesterol because they are inexpensive, taken daily, and backed by decades of evidence showing reduced risk of heart attack, stroke, and death. They can lower LDL by 30–50%, but some people experience side effects like muscle aches or liver enzyme changes, and their benefit in older adults without prior heart disease is less certain. Leqvio (inclisiran) is a newer option given by injection twice a year that lowers LDL by about 50% and avoids muscle or liver toxicity, making it useful for patients who cannot tolerate statins or whose cholesterol remains high despite them. However, Leqvio is costly, long-term outcome data are still accumulating, and it is usually prescribed as an add-on rather than a replacement. In short, statins are proven and affordable, while Leqvio offers convenience and potent LDL reduction but at higher cost and with less long-term track record.

Drug Comparisons

Mayo Clinic Article On Statins

Harvard Health Article

In short, for people older than 75 who have heart disease already, or who, like you, are at increased risk of developing heart disease, I think there now is solid evidence that statins remain effective at lowering cholesterol and, more important, in reducing the risk of new or recurrent heart disease. For people older than 75 who have not been diagnosed with heart disease and are not at increased risk for developing it, I think the value of statins still is uncertain.
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