re: Pulmonologist Roy Culotta at Baton Rouge General posted about current situation

quote:

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Ask him if he's giving ivermectin and corticosteroids, since you know him well, and let's us know what he said. Thanks.


He won’t ask him because he never heard of the guy until today.

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1. Ivermectin to have any possible antiviral benefits it has to be given at dosages that are above the TD50 (dosage at which 50% of recipients experience some form of toxic adverse effect(s)) for ivermectin and 5x higher than the FDA approved dosage IIRC. Ivermectin is neurotoxic, but it does not cross the blood-brain barrier (BBB) at the FDA approved dosages so it is safe at the FDA approved dosages. However if ivermectin is given at dosages high enough to have an antiviral effects (again 5x the FDA approved dosage IRRC) the serum concentration is high enough to force ivermectin across the (BBB) and enter the brain.

2. Corticosteroids interacts with Ivermectin and makes it easier for Ivermectin to cross the BBB. Making it easier for a neurotoxic agent to cross the BBB is something that should be avoided.

3. If you give ivermectin at the dosages needed for it to have any antiviral effect(s) and combine it with steroids then not only are you driving a neurotoxic agent across the BBB, but you are driving a neurotoxic agent across the BBB at dosages that are much higher than the TD50 and dosages that are approaching the LD50 (dosage at which 50% of recipients die).

4. If you combine ivermectin at doses high enough to have antiviral effects and corticosteroids then you are definitely going to cause brain damage and very possibly cause coma and/or brain death. All of those are bad and reasons why nobody gives ivermectin and corticosteroids.