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re: So how are Semaglutides healthy?

Posted on 10/10/24 at 1:42 pm to
Posted by CatfishJohn
Member since Jun 2020
17031 posts
Posted on 10/10/24 at 1:42 pm to
quote:

I understand that’s how it’s supposed to work but seems a whole lot of people don’t follow that because they find it difficult to eat the amount of food they need for proper nutrition. If they try to they feel sick, so they just don’t eat anything


We have a semi-friend on it and he's lost an obscene amount of weight over a 6 month period. Looks like a totally different person, and that's not hyperbole.

My wife said he eats a hard boiled egg in the morning, fruit and nuts for lunch, a chicken breast or salmon or steak with no sides for dinner.

That's wild to me. I'd be the meanest sonofabitch you ever met if I was constantly hungry from that diet

Posted by Epic Cajun
Lafayette, LA
Member since Feb 2013
35342 posts
Posted on 10/10/24 at 1:59 pm to
quote:


Another question - do these drugs do anything to help you lose weight other than suppress appetite?

For example, take 2 identical twins on identical diets. One takes these drugs and eats less. One doesn't take these drugs and eats the same as his twin (less). It's a very controlled study. Will they hypothetically, all else being the same, lose weight at the same rate? Or do these drugs change how the body metabolizes existing fat/muscle in a way that is different than someone on the same diet but not on these drugs?

I could be wrong, but I'm almost 100% sure that it's just the reduced caloric intake that is causing the weight loss.
Posted by BluegrassBelle
RIP Hefty Lefty - 1981-2019
Member since Nov 2010
104112 posts
Posted on 10/10/24 at 2:00 pm to
quote:

I could be wrong, but I'm almost 100% sure that it's just the reduced caloric intake that is causing the weight loss.


It targets rumination as well. It's why they're looking at it for addiction and eating disorders off-label. There's a brain/thought component to it as well as the reduced appetite.
Posted by Epic Cajun
Lafayette, LA
Member since Feb 2013
35342 posts
Posted on 10/10/24 at 2:02 pm to
quote:

It targets rumination as well. It's why they're looking at it for addiction and eating disorders off-label. There's a brain/thought component to it as well as the reduced appetite.

But the brain/thought component isn't causing you to lose weight, it's the reduced calories still that is causing that, right?
Posted by LemmyLives
Texas
Member since Mar 2019
10340 posts
Posted on 10/10/24 at 2:05 pm to
I think I remember Dr Drew also mentioning that it curbed alcohol cravings too.
Posted by BluegrassBelle
RIP Hefty Lefty - 1981-2019
Member since Nov 2010
104112 posts
Posted on 10/10/24 at 2:06 pm to
quote:

But the brain/thought component isn't causing you to lose weight, it's the reduced calories still that is causing that, right?


The reduced rumination leads to less focus on food, so yes it would result in less eating if rumination is an issue for you.
Posted by bigjoe1
Member since Jan 2024
911 posts
Posted on 10/10/24 at 2:06 pm to
quote:

But the brain/thought component isn't causing you to lose weight, it's the reduced calories still that is causing that, right?


I think she is talking about controlling binge eating. You're right. At its core you lose weight by burning more calories than you consume.
Posted by lsu777
Lake Charles
Member since Jan 2004
34991 posts
Posted on 10/10/24 at 2:07 pm to
quote:


I get the weight loss aspect but I’m talking from a nutrition point of view. Our bodies require certain nutrients and minerals to function.

I know some people who literally do not eat hardly at all. One I know went from normal eating (2 meals a day and occasional snacks) to eating one small serving of cottage cheese a day. And soon as that person sees the weight loss amount start to plateau the dr ups the dosage. I’ve been told if they try to eat they feel sick

At some point wouldn’t you be malnourished and have serious health issues/organ failure?


because most have all the nutrients they need stored in their fat asses

but in general yes they are healthy. your body can go long periods of not eating when you are a fatty and still be healthy

they help blood sugar, heart health, cholesterol etc

GLP is a naturally occurring hormone on the body that is suppressed in those that are obese. its just raising that natural hormone.

and if the person you you knew was only eating 2 meals and a small snack...they wouldnt be overweight in general

and just because the doctors are dumbasses and continue to raise the damn dose way over the minimum effective dose and patients continue to abuse the medicine doesnt mean its not safe or healthy

the problem is people are lazy and most doctors are dumb AF when it comes to nutrition and exercise

got plenty of bodybuilders using these drugs for contest prep and they arent losing muscle. in fact GLP1 is actually anticatabolic

difference is one is just relying on the medicine to lose the weight, the other is meticulous in their macros and lifting heavy arse weights.


but overall multi year long studies show that it improves health big time according to all known blood marker indicators.
Posted by lsu777
Lake Charles
Member since Jan 2004
34991 posts
Posted on 10/10/24 at 2:13 pm to
quote:

Other than the obvious of not having as much food in your belly at any given time, do these drugs react negatively with alcohol in any way?


no, it is just replacement of a naturally occurring hormone that normally tells you when you are satiated.


now with that being said, you will crave alcohol much less and glp1 are being study to help cure alcoholism. One of the ways it makes you feel full is it works on the dopamine center of the brain so that you dont get pleasure from certain things like alcohol and certain foods. this is why you hear of people saying for the first time in their life the "food noise" is gone. most people lose the impulse to drink. tends to make people not like the taste too, same with soft drinks

this also works for curing the hyper sexual and somewhat for gambling as they all work on the same part of the brain

now that is not without downsides to that. at high doses it tends to kill the sex drive for many, especially when other hormones are present like low test(women and men) and in men when protein levels are not maintained and resistance training is not performed...tends to be more prelevant

now for some women on the mid dose, after some weight loss they tend to be more sexually active, this is due to new found confidence

sex drive returns for most to above prior levels as weight loss goals are reached and dose is lowered
Posted by lsu777
Lake Charles
Member since Jan 2004
34991 posts
Posted on 10/10/24 at 2:16 pm to
quote:

Another question - do these drugs do anything to help you lose weight other than suppress appetite?

For example, take 2 identical twins on identical diets. One takes these drugs and eats less. One doesn't take these drugs and eats the same as his twin (less). It's a very controlled study. Will they hypothetically, all else being the same, lose weight at the same rate? Or do these drugs change how the body metabolizes existing fat/muscle in a way that is different than someone on the same diet but not on these drugs?


it doesnt change the metabolism of the body and has zero catabolic effect or any uncoupling mechanism

so if calories are the same, macros are the same so dietary induced thermo is the same, activity levels are exactly the same....should be the same weight

one on the medicine prolly has better blood markers though and was prolly much happier during the diet phase.
Posted by PsychTiger
Member since Jul 2004
104645 posts
Posted on 10/10/24 at 2:18 pm to
quote:

But the OT said it will make me blind.


They weren't talking about your eating, but the other thing you do with your hands.
Posted by Epic Cajun
Lafayette, LA
Member since Feb 2013
35342 posts
Posted on 10/10/24 at 2:19 pm to
quote:

The reduced rumination leads to less focus on food, so yes it would result in less eating if rumination is an issue for you.

But ultimately it’s the amount of calories that are going into your body (or lack there of) that is causing the weight loss. The poster asked if you have twins and one is taking the meds and the other is not and they started at the same weight and consumed the same exact foods and calories would there be a difference in weight loss? The answer is no, right?
Posted by lsu777
Lake Charles
Member since Jan 2004
34991 posts
Posted on 10/10/24 at 2:23 pm to
quote:

But ultimately it’s the amount of calories that are going into your body (or lack there of) that is causing the weight loss. The poster asked if you have twins and one is taking the meds and the other is not and they started at the same weight and consumed the same exact foods and calories would there be a difference in weight loss? The answer is no, right?


correct

there is no known mechanism of action where any of the GLP1 or GIP based medicines could cause any increase in metabolism either through thermogenesis or some uncoupling action


and as i said above...theoretically they would be the same weight..but as belle alluded too....one would have been much happier along the way due to less or zero food noise.
This post was edited on 10/10/24 at 2:24 pm
Posted by HouseMom
Member since Jun 2020
1392 posts
Posted on 10/10/24 at 2:29 pm to
quote:

But ultimately it’s the amount of calories that are going into your body (or lack there of) that is causing the weight loss.


Correct. It's basically medically induced anorexia. It makes you think you're satiated so you don't eat any more.

But to your point, yes, it's no different than just having self control and eating less. Calories in vs. calories out is still the gold standard.
Posted by CoachChappy
Member since May 2013
33929 posts
Posted on 10/10/24 at 2:29 pm to
quote:

At some point wouldn’t you be malnourished and have serious health issues/organ failure?


If you have body fat, your body will turn to that fat for food. You can go a long time without eating.
Posted by wheelr
Banned
Member since Jul 2012
5800 posts
Posted on 10/10/24 at 2:37 pm to
Food sitting in your stomach for multiple days doesn't seem healthy.
Posted by TigerDat
Member since Aug 2010
7881 posts
Posted on 10/10/24 at 2:44 pm to
quote:

It does nothing for appetite suppression for me but it does lower my A1C.


Same. I started Mounjaro which is a trizepetide and for the first 3-5 months loasf about 60 lbs. But now that has plateaus and I don't notice the appetite suppression as much but my A1C is down from 7.4 to 5.3.

Posted by ds_engineer
South Mississippi
Member since Dec 2014
403 posts
Posted on 10/10/24 at 2:45 pm to
quote:

At some point wouldn’t you be malnourished and have serious health issues/organ failure?


What a weird thing for so many downvotes. I share the same concerns. I know a few people who look very sickly on that stuff. It doesn't seem like a health approach to weight loss.
Posted by JellyRoll
Member since Apr 2024
973 posts
Posted on 10/10/24 at 2:49 pm to
quote:

your doctor needs to get in your arse


That's some kinky medical care if you ask me
Posted by LNCHBOX
70448
Member since Jun 2009
86891 posts
Posted on 10/10/24 at 2:50 pm to
quote:

What a weird thing for so many downvotes. I share the same concerns. I know a few people who look very sickly on that stuff. It doesn't seem like a health approach to weight loss.



You think they were getting proper nutrients while they were fat? Yeas, these people you know likely lost muscle while losing the weight. But is that worse than being a fatty?
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