bigjoe1

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A new cancer treatment has completely eliminated tumors in some patients with advanced head and neck cancer whose disease had stopped responding to standard treatments, the Guardian reported on Saturday.

Results from the international OrigAMI-4 trial showed that the experimental drug amivantamab shrank or eliminated tumors in 43 of 102 patients whose cancer had spread or returned after chemotherapy and immunotherapy failed.

Among them, 15 patients saw their tumors disappear completely.

Kevin Harrington of the Institute of Cancer Research and the Royal Marsden NHS Foundation Trust called the results "unprecedentedly strong responses" in patients with few remaining treatment options.

"This is a group of patients for whom treatment options are extremely limited, so seeing this level of benefit is very striking," Harrington said.

The findings will be presented at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago.

Amivantamab attacks cancer in three ways.

It blocks the EGFR protein that helps tumors grow, blocks the MET pathway that cancer cells often use to escape treatment, and helps activate the immune system to attack tumors.

Researchers said the drug is given as a small injection under the skin rather than through an IV, making treatment faster and easier to administer.

Most side effects were mild to moderate, and fewer than one in 10 patients stopped treatment because of them.

One patient, Carl Walsh, 56, of Birmingham, joined the trial after chemotherapy and immunotherapy failed to control his tongue cancer.

"I was initially treated with both chemotherapy and immunotherapy, which unfortunately were not successful," Walsh said.

"At that point, I was recommended for the OrigAMI-4 trial," he said.

Walsh said the treatment significantly improved his quality of life.

"I now feel able to live a normal life," he said.

"Since beginning treatment, the swelling has reduced significantly, and my pain levels have improved considerably," he said.

He added that after two treatment cycles he began eating normally again and eventually enjoyed "the first big steak" after months of eating soft foods.

Researchers noted that the study focused on HPV-negative head and neck cancers, which are generally harder to treat and have worse outcomes than HPV-related cancers.

Patients in the trial lived a median of 12.5 months after starting treatment despite having advanced disease that had progressed after standard therapies.

The results remain preliminary and larger studies will be needed to confirm the benefits.

Amivantamab, developed by Johnson & Johnson, is currently being studied in about 60 clinical trials, including for lung, colorectal, brain, and stomach cancers.

Kristian Helin, chief executive of the Institute of Cancer Research, said the findings represent "a significant step forward" for patients with very limited treatment options.

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n general, “whiter, richer, less-immigrant communities were more beautiful, less smelly, smarter,” according to the model, Zook said. The model is “reinforcing what it’s learned from the data it’s been fed ... which includes the biases, the prejudice” of available training materials, he said.

In this way, the ChatGPT answers are not neutral and can reflect racist ideas. For example, Mississippi, a state with a high population of Black residents, was the state with the most “ignorant” people, according to the model.

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don’t think arms to the people are going to do it. Nobody wants to admit it but the revolutionary element got purged before we could get clear of the Olympics and not do norm breaking (sorta like Russia waiting until after the Olympics in 2022). There was some sort of secrecy break down and the regime cracked down hard.

At this juncture collapsing the regime is going to be on US-Israel destroying cities and infrastructure causing complete civil collapse. There is no little shove of decapitation strikes that is going to do it now. Our timing got fricked up and the internal forces we likely hoped to seize the initiative in the power vacuum got purged.

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Exxon Mobil
warned Thursday that oil inventories will fall to record low levels in coming weeks, forcing prices to spike and curbing demand.

“We’re approaching unheard of inventory levels,” said Exxon Senior Vice President Neil Chapman at a conference hosted by Bernstein in New York.

“I mean really, really low levels,” Chapman warned. “You can debate whether that’s going to hit, those really low levels, in two weeks or three weeks. Once you get to that point, then you’ll see price shoot up.”

The price of physical Brent oil cargoes will spike to $150 to $160 per barrel when inventories hit all-time lows in coming weeks, the executive said. “When the price gets to a certain level, demand destruction brings it back into balance,” he said.

Brent
futures for July delivery, the nearest contract, closed under $94 per barrel Thursday as investors once again held out hope for a settlement between the U.S. and Iran that will reopen the Strait of Hormuz.

Iran’s closure of the strait has cost the market more than a billion barrels so far, the largest oil supply disruption in history, according to the International Energy Agency. Oil stockpiles have mitigated the impact so far, but that “can’t last forever,” Chapman said.

The IEA warned earlier this month that inventories are being depleted at a record pace. The organization’s members agreed in March to release a record 400 million barrels to lessen the impact of the supply disruption.

Oil industry executives have warned for two months that the crude futures market is not reflecting the scale of the disruption triggered by the war in the Middle East.

“I don’t know, whether it’s two to three weeks or three to four weeks,” Chapman said. “What I’m really saying is, once you get to the minimum inventory levels and all-time low inventory levels, there’s only one way to go. That’s the situation.”

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My take is Trump just wants to lower gas prices and put the war on ice until the midterms. I expect we will only know his real Iran plans after those.

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But Trump can't negotiate with the Arabs from his current position during a ceasefire, because they see this as weakness and they don't believe in signing onto weakness. This is the middle east and weakness is immediately punished.

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If Trump does this, he's a freaking moron. shite or get off the pot.

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The Dambusters Raid (May 1943): Operation Chastise saw RAF Squadron 617 use specialized "bouncing bombs" to breach the Möhne and Eder dams. The resulting floods severely disrupted the valley's raw material supplies and rail networks, killing over 1,000 people (many of whom were foreign forced laborers).

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