re: Has anyone talked about the Mr. Beast guy (Chris) going trans?

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Oh wow, you want to hear about my anecdata now?

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my anecdata don't want none unless you got some son!

I mean, I generally just try to call bad-faith morons here as what they are, but I'll engage with you.

Firstly, there are categories of gender dysphoria cases that are categorized as gender dysphoria with DSD (or developmental sex disorders) and gender dysphoria without DSDs. The research in developmental sex disorders only really started finding distinct genetic origins for these disorders after the 1990s. For example, XY gonadal dysgenesis was linked to the MAP3K1 gene and the MIER3 gene on chromosome 5, and that link was only established in 2003. A loss of function mutation in FGFR2 leading to XY reversal was only described in 2008. Because of the rate at which we can start accurately describing both pathologic and genetic trends, of course there is going to be a rise in gender dysphoria cases overall. It's not something sinister unless you want to look at it that way and that way alone. Since 2019, we've discovered estrogen receptor site mutations that could possibly mediate estrogen resistance in a way not dissimilar to androgen insensitivity syndrome. In one sense, there was always going to be an increase in the rate of cases because we had pathologic frameworks with which to describe diseases. I spoke to one endocrinologist who said he stopped karyotyping kids who presented with refractory gender dysphoria because the presentations between children who had a known DSD and no defined DSD were very similar. The preliminary brain scan data, which showed that trans people had brain scans more similar to their identified gender than their identified gender regardless of the presence of a DSD shows suggests a multifactorial neuroendocrine etiology likely to do with dysfunction along the HPA axis, not unlike other disorders of sex development like congenital adrenal hyperplasia. My personal theory, given some informal interviews, along with some of the newer genetic data, suggests something like transient cortisol dysfunction during key weeks in pregnancy can have profound changes along the HPA axis, which at least gives a pathologic framework.

How much does he win if he does it for a full year?

So this is what explains the meteoric rise in transgender kids? A sudden medical discovery over the past few years?

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but from my current understanding it is seen as pretty controversial to claim there are traits inherent to each biological sex that one could reliably identify via brain imaging alone.

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Yeah, I didn't word that properly, and the differences in the brain scan data all had to do with the sizes of different nuclei in the hypothalamus, which aren't definitive in terms of assigning sex, but in the framework of a larger constellation of evidence, it might be meaningful. The study that did come out was only an abstract I think, and I don't think that full study has been published, or reproduced, but my suspicion is that some dysfunction along the HPA axis can explain the cases of gender dysphoria without a definite DSD.

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So this is what explains the meteoric rise in transgender kids? A sudden medical discovery over the past few years?

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I keep seeing this repeated without seeing the actual data, but relative to where we were in the description of the disease 30 years ago, that is the easiest explanation. As we get better at defining and categorizing a disease, the incidence and prevalence statistics should go up. The issue with gender dysphoria is that I don't know how robust using the DSM-V characteristics are with respect to diagnostic sensitivity, given the absence of a pathognomonic sign or a more definitive test. The one thing that does aid the current diagnostic categories is the sheer duration with which patients have to have symptoms in order to receive a diagnosis.

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Mr. Beast Who the frick is this?

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Maker of shitty candy bars?

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I keep seeing this repeated without seeing the actual data, but relative to where we were in the description of the disease 30 years ago, that is the easiest explanation. As we get better at defining and categorizing a disease, the incidence and prevalence statistics should go up. The issue with gender dysphoria is that I don't know how robust using the DSM-V characteristics are with respect to diagnostic sensitivity, given the absence of a pathognomonic sign or a more definitive test. The one thing that does aid the current diagnostic categories is the sheer duration with which patients have to have symptoms in order to receive a diagnosis.

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I get that you're trying to approach this from a medical stance, but I think the social influence of this is 99% of the issue. I can't fathom how we've gone thousands of years as a species without this issue then a massive spike in the last decade.

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Well, your anecdotal experience obviously completely negates the sharp rise in child transgenderism.

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Its been around forever, and its increase in current society is specifically linked to access to social media. Its correct terminology shouldnt be transgender, because its clearly . . . .

Munchausen syndrome by proxy