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re: Coronavirus Disease 2019 (COVID-19) ***W.H.O. DECLARES A GLOBAL PANDEMIC***

Posted on 3/14/20 at 7:46 am to
Posted by MadDogs
Member since Jul 2018
454 posts
Posted on 3/14/20 at 7:46 am to
quote:

We know that the elderly are much more likely to be Vitmain D deficient. Could this play a role in this disease?

I'm interested in hearing what you find. I'm not a big supplement person either, but I started taking a daily multivitamin about a year ago and have been generally healthier in that time. I sometimes have a crap diet so the vitamin is just to make up for some of what I'm missing out on. It has 1000IU of vitamin D.

I always thought D was fat soluble and it is possible to have to much of it. Is that not the case?
Posted by Tiguar
Montana
Member since Mar 2012
33131 posts
Posted on 3/14/20 at 7:49 am to
1. You can overdose on vitamin D, it can cause liver failure

2. The link between vitamin D and your immune system has been established for awhile. People with low vitamin D are at an increased risk of infection

3. Speaking to 2, I got 2-3 URTIs a year until I found out my vit D was low and I started taking RX supplements. I haven’t really gotten “sick” since and that was almost 8 months ago

4. Taking vitamin D when your levels aren’t low probably won’t help but don’t take more than 1000-2000u a day and you won’t OD
Posted by WaWaWeeWa
Member since Oct 2015
15714 posts
Posted on 3/14/20 at 7:51 am to
Vitamin D

LINK

quote:

The Th1-stimulated response is the key for many bacterial and viral infections, but if it is an uncontrolled process, it leads to autoimmunity [28]. What is the role of vitamin D in that type of immune response? It acts as a modulator of Th cell proliferation and cytokine production, but also through promoting Treg cells, which are responsible for anti-infectious action, for suppressing immune responses, and for limiting inflammatory processes [28].


quote:

As such, this vitamin acts through the promotion of the feedback loop to prevent the overactivity of antibacterial processes and inflammatory events. Such action includes the downregulation of TLR2 and TLR4 on monocytes [25,29]. 1a,25(OH)2Dhas been reported to decrease proinflammatory chemokine production in human respiratory epithelial cells


quote:

most important is the 1a,25(OH)2D-stimulated production of AMPs, such as defensin and cathelicidin. As mentioned, these endogenous antibiotics act directly, destroying not only microbial pathogens, but also viruses, including the influenza virus


quote:

The release of proinflammatory cytokines by the influenza virus appeared to correlate with the severity of illness [24]. Khare et al. [50] noted that treatment of human lung A549 epithelial cells with 100 or 30 nM of 1a,25(OH)2D prior to or post-H1N1 (influenza A virus) exposure significantly decreased the levels of infection-induced TNFa, IFNß, and IFN-stimulated gene-15 (ISG15) and downregulated IL-8 and IL-6 RNA levels.



Anyone else with a science background? I’d love to here your thoughts on Vitamin D. I’m going to continue to look into this.
Posted by Volvagia
Fort Worth
Member since Mar 2006
53474 posts
Posted on 3/14/20 at 7:51 am to
quote:


Edit: Wa or Vol are you guys on here tonight, I could use some advice.


You are lucky I saw this.

Basically abandoned the thread as an useless shitstorm

What’s up?
This post was edited on 3/14/20 at 7:52 am
Posted by Rhino5
Atlanta
Member since Nov 2014
30963 posts
Posted on 3/14/20 at 7:51 am to
quote:

Two people were shot and killed in a south Alabama Walmart over toilet paper. Reported by ABC 3340. The wife just showed me the article from her Facebook page. Killed over charmin. Freaking idiots.



Unreal
Posted by WaWaWeeWa
Member since Oct 2015
15714 posts
Posted on 3/14/20 at 7:55 am to
quote:

Speaking to 2, I got 2-3 URTIs a year until I found out my vit D was low and I started taking RX supplements. I haven’t really gotten “sick” since and that was almost 8 months ago


Interesting

quote:

Taking vitamin D when your levels aren’t low probably won’t help but don’t take more than 1000-2000u a day and you won’t OD


I agree completely. I would imagine the elderly nursing home population would have very low vitamin D levels.

I’m also curious what role vitamin D might play in a cytokines storm situation. From what I’m reading Vit D is very helpful in regulating the immune system and cytokines release.

Thanks for your response
Posted by Commander Data
Baton Rouge, La
Member since Dec 2016
7291 posts
Posted on 3/14/20 at 7:57 am to
quote:

You can overdose on vitamin D, it can cause liver failure


Not according to my doctor.

quote:

but don’t take more than 1000-2000u a day and you won’t OD

You know you can buy 5000u at Walmart. 5000 per pill. If it were unsafe to take that dose you wouldn't be able to buy it. I take 3 of the 5000u every morning.
Posted by Winston Cup
Dallas Cowboys Fan
Member since May 2016
66922 posts
Posted on 3/14/20 at 7:59 am to
I don’t want to downplay c19 out of respect for those who actually have had loved ones who have died, but please be aware (especially if you live in Texas) that oak pollen is extremely high right now and has the similar symptoms to corona. Maybe take an allergy pill and see how you feel in 30 minutes before rushing to the ER



Notice the bell curve likely follows the same as corona likely will. It may just be respiratory distress from allergies
Posted by brickyard
Member since Jan 2007
625 posts
Posted on 3/14/20 at 8:00 am to
Should part of the message be, for those with yards etc, to be planting fruits and vegetables? Also, those with the means, to get a couple of chickens? Seems like a win win win. You’re not going to store as much so you’re not spreading, getting illness. Plus it makes people more self reliant. As well as healthy eating.
I know it’s hard for some to believe, but stores haven’t been around forever and people survived.
I don’t know. It’d probably be such a small amount of people that would give it a shot that it wouldn’t make much of a difference.
Posted by WaWaWeeWa
Member since Oct 2015
15714 posts
Posted on 3/14/20 at 8:01 am to
quote:

Urashima et al. [54], who conducted a randomized, double-blind, placebo-controlled trial comparing vitamin D3 supplements (1200 IU/day) with placebo in schoolchildren from December to March. The outcome was the incidence of influenza A diagnosed with presence of the influenza antigen. As reported, influenza A occurred in 18 out of 167 (10.8%) children in the vitamin group compared with 31 out of 167 (18.6%) children in the placebo group (relative risk (RR) = 0.58; 95% CI: 0.34, 0.99; p = 0.04). The reduction of influenza incidence was greater in children who, among other factors, had not been taking other vitamin D supplements. It is interesting to note that in children with a previous diagnosis of asthma, asthma attacks as a secondary outcome occurred in two children receiving vitamin D compared with twelve children receiving placebo (RR = 0.17; 95% CI: 0.04, 0.73; p = 0.06).


quote:

Intriguing effects were presented by Mamani et al. [59] and Brance et al. [60] in their studies. Both studies showed an inverse correlation between the level of 25(OH)D and the severity of CAP (community-acquired pneumonia), which was defined as the CURB65 score (confusion, uremia, respiratory rate, low blood pressure, =65 years).
This post was edited on 3/14/20 at 8:02 am
Posted by Tiguar
Montana
Member since Mar 2012
33131 posts
Posted on 3/14/20 at 8:04 am to
5000u per day is what people take who are deficient. The logic of something being at Walmart meaning you can’t OD on it. Hoo boy

You can absolutely harm yourself by taking too much vitamin D although you’re more likely to get minor side effects from the secondary hyper calcemia

But the main take home point is unless you’re deficient, it probably won’t help too much
Posted by Honkus
Member since Aug 2005
57989 posts
Posted on 3/14/20 at 8:06 am to
quote:

You are lucky I saw this.


That was from last night baw, she gone



Posted by Volvagia
Fort Worth
Member since Mar 2006
53474 posts
Posted on 3/14/20 at 8:07 am to
She was online when I posted....just missed her.
Posted by Hulkklogan
Baton Rouge, LA
Member since Oct 2010
43482 posts
Posted on 3/14/20 at 8:07 am to
My vitamin d level was 27 a couple of years ago. I take 20,000IU of D3 every other day and it's up to 80 now.
Posted by ctiger69
Member since May 2005
31030 posts
Posted on 3/14/20 at 8:10 am to
Good AM sheep.
Posted by WaWaWeeWa
Member since Oct 2015
15714 posts
Posted on 3/14/20 at 8:14 am to
quote:

You can absolutely harm yourself by taking too much vitamin D although you’re more likely to get minor side effects from the secondary hyper calcemia


He’s 100% correct

quote:

But the main take home point is unless you’re deficient, it probably won’t help too much


I agree
Posted by Ronaldo Burgundiaz
NWA
Member since Jan 2012
6793 posts
Posted on 3/14/20 at 8:20 am to
arse to mouth may be back on the menu, boys.

One study shows the virus found in stool samples have been found to be inactive.

quote:

Virus isolation from stool samples was never successful, irrespective of viral RNA
concentration, based on a total of 13 samples taken between days six to twelve from four
patients. Infectious virus was readily isolated
from throat- and lung-derived samples, but not from stool samples in spite of high
virus RNA concentration


Clinical presentation and virological assessment of hospitalized cases of coronavirus disease 2019 in a travel-associated transmission cluster < have to open the PDF

Bonus conclusion from that paper:
quote:

Conclusions: The present study shows that COVID-19 can often present as a common cold-like illness.

Posted by St Augustine
The Pauper of the Surf
Member since Mar 2006
72131 posts
Posted on 3/14/20 at 8:21 am to
quote:

My vitamin d level was 27 a couple of years ago. I take 20,000IU of D3 every other day and it's up to 80 now.


I was in the high 20s as well. I don’t take near that much but got it into the mid 50s through supplements.
Posted by Commander Data
Baton Rouge, La
Member since Dec 2016
7291 posts
Posted on 3/14/20 at 8:25 am to
Ok, thanks for telling me this. My doctor told me I could safely take a as much as I wanted. I may get kidney stones from it.
Posted by CoastLSUFan
Member since Nov 2010
751 posts
Posted on 3/14/20 at 8:28 am to
I’m not sure if this is accurate, but I always heard that a person can get enough vitamin D by being in the sunshine with face and forearms exposed for 10 minutes a day. Can any medical people confirm this?

I much prefer to be outdoors than indoors, and I go on a 4-mile walk on a wooded path (sunny and shady spots along the way) most days (weather permitting). It just seems like people exercising outdoors right now could have multiple benefits: the obvious cardiovascular benefits, less exposure to virus carriers, bolstered immune system (from vitamin D), breathing in fresh air/oxygen, and the psychological benefits from being in nature. It would definitely help people not feel so anxious in this age of social distancing.
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