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re: Testosterone-replacement therapy does not increase cardiac events in men

Posted on 9/14/23 at 8:25 am to
Posted by LSUPERMAN
Louisiana
Member since Aug 2007
3029 posts
Posted on 9/14/23 at 8:25 am to
Which do you think is better? Gel or injection?
Posted by lsu777
Lake Charles
Member since Jan 2004
38054 posts
Posted on 9/14/23 at 9:08 am to
injection and not even close. i have tried transdermals...no thank you.
Posted by tke_swamprat
Houma, LA
Member since Aug 2004
11127 posts
Posted on 9/14/23 at 9:16 am to
I agree. I did the creams. It worked well but applying 2 times a day gets old. Plus in Louisiana as soon as you walk outside you start to sweat so depending on how long you applied it, it may not absorb as well.

Posted by jose
Member since Feb 2009
29729 posts
Posted on 9/14/23 at 9:45 am to
My biggest qualm with TRT is that a lot of patients come see me and when I saw I am going to check their levels they get mad at me. They expect me to put them on it willy nilly.

I tell them I am not starting it if their levels are normal and then if they are normal, I usually never see them again for anything.
Posted by LEASTBAY
Member since Aug 2007
16560 posts
Posted on 9/14/23 at 9:48 am to
quote:

check their levels they get mad at me.


Curious as to why this would be. I use an online clinic and they check mine periodically. Including CMP, lipids etc. Most I just upload from my primary care.
This post was edited on 9/14/23 at 9:50 am
Posted by jose
Member since Feb 2009
29729 posts
Posted on 9/14/23 at 9:57 am to
quote:

Curious as to why this would be


They come see me for various reasons and just hope that I start them on it.

I tell them all about the CVS risks and then understand or at least pretend to. But if they are low, I will treat them no doubt.
Posted by LEASTBAY
Member since Aug 2007
16560 posts
Posted on 9/14/23 at 9:58 am to
Just curious as to why they would be angry about getting labs? Maybe the cost?
Posted by jose
Member since Feb 2009
29729 posts
Posted on 9/14/23 at 9:59 am to
Maybe so, but if you bill for it correctly insurance covers it anyways.
Posted by bayouvette
Raceland
Member since Oct 2005
5897 posts
Posted on 9/14/23 at 10:08 am to
I really don't trust studies but this is a major reason I haven't jumped on the bandwagon yet. My dad's side has heart issues and it's a big concern for me..
Posted by h0bnail
Member since Sep 2009
7628 posts
Posted on 9/14/23 at 10:08 am to
quote:

Just curious as to why they would be angry about getting labs?


Probably just want T, regardless of whether they need it or not.
Posted by LEASTBAY
Member since Aug 2007
16560 posts
Posted on 9/14/23 at 10:17 am to
quote:

My dad's side has heart issues and it's a big concern for me..


I have had mitral repair which was a pretty extensive surgery and am followed by a cardiologist. They say I'm doing better than ever right now and I feel it. I don't blame you though.
Posted by tke_swamprat
Houma, LA
Member since Aug 2004
11127 posts
Posted on 9/14/23 at 11:05 am to
You would think most would want the labs to get things dialed in. I know people who have done this, got on TRT to see the optimum dosage and then switch over to the black market.

If they just want to get on test for the sake of it, just go to a local gym, and ask around. It is not that hard to get.
Posted by jose
Member since Feb 2009
29729 posts
Posted on 9/14/23 at 11:12 am to
Agreed!!

Don't get mad at me for trying to diagnose hypogonadism and treat you appropriately
Posted by lsu777
Lake Charles
Member since Jan 2004
38054 posts
Posted on 9/14/23 at 11:14 am to
quote:

I tell them all about the CVS risks and then understand or at least pretend to. But if they are low, I will treat them no doubt.


there are no cvs risk. i posted the study that 100% disputes that and then another poster on page 2 went into way deeper on why the OG study was just plain wrong from a statistical standpoint.


peopel that dont want to test their levels and track it though are just trying to use steroids with a script. No other reason to not be getting tested 2x per year.

quote:

I really don't trust studies but this is a major reason I haven't jumped on the bandwagon yet. My dad's side has heart issues and it's a big concern for me..


so if we are talking real trt as in replacement doses putting you within normal ranges for your age group, what would be your concern? would you be concerned if your levels were naturally there? there is no difference. and if you were naturally there, you shouldnt be on trt to begin with.

im not encouraging you to go on. in fact i discourage people to go on and encourage them to do everything they can before hand to try and fix the problem without going on. trt sounds cool until your in year 10 and suddenly subq gives you bruising and you have to pin through scar tissue every damn injection knowing you have 40-50 years, god willing, of repeating this.


hopefully the autopin subq injection comes to fruition sooner rather than later.
Posted by lsu777
Lake Charles
Member since Jan 2004
38054 posts
Posted on 9/14/23 at 11:15 am to
quote:

You would think most would want the labs to get things dialed in. I know people who have done this, got on TRT to see the optimum dosage and then switch over to the black market.

If they just want to get on test for the sake of it, just go to a local gym, and ask around. It is not that hard to get.



i get this to an extent if insurance isnt covering things, but with goodrx the script isnt much more, if at all, than black market.
Posted by jose
Member since Feb 2009
29729 posts
Posted on 9/14/23 at 11:17 am to
quote:

quote:
I tell them all about the CVS risks and then understand or at least pretend to. But if they are low, I will treat them no doubt.


there are no cvs risk. i posted the study that 100% disputes that and then another poster on page 2 went into way deeper on why the OG study was just plain wrong from a statistical standpoint.


Correct me if I am wrong, but doesn't your study say the people in the study had hypogonadism? Does it mention how folks who are not testosterone deficient responded? That's my argument I guess.
Posted by lsu777
Lake Charles
Member since Jan 2004
38054 posts
Posted on 9/14/23 at 11:48 am to
it said

quote:

In men with hypogonadism and preexisting or a high risk of cardiovascular disease, testosterone-replacement therapy was noninferior to placebo with respect to the incidence of major adverse cardiac events.


so even if you have pre-existing heart issues....if you have hypogonadism, you are at no increase risk of cardiac events


as far as those that are not hypogonadism....you are causing that once you inject the hormone. you arent adding on top. you are shutting all natural production down within 28 days. so no increased risk there


but yo your point...if you dont have hypogonadism to the point you are out of range for your age then why would you want to get on TRT to start with?


i underlined the above because its important to not just look at overall numbers, but ranges for the age of the patient and even more important to focus on free test not total test.

but there is room for optimization if that is what the patient would like but optimizing with TRT just to optimize brings along all the downsides of trt in terms of sperm quality/quantity, neg feedback loops etc just for the sake of optimizing in a range that is not going to give you any crazy benefits imo.
Posted by tke_swamprat
Houma, LA
Member since Aug 2004
11127 posts
Posted on 9/14/23 at 11:54 am to
But you still have to go to the provider to get the script. Easier to go to Joe at the gym and hand him $80 dollars for a 300mg 10ml vial.
Posted by lsu777
Lake Charles
Member since Jan 2004
38054 posts
Posted on 9/14/23 at 11:57 am to
alot more risk involved too though, legally and medically.
Posted by jose
Member since Feb 2009
29729 posts
Posted on 9/14/23 at 12:55 pm to
quote:

but yo your point...if you dont have hypogonadism to the point you are out of range for your age then why would you want to get on TRT to start with?



Tell my patients that. Your guess is as good as mine.
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