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Jim Rockford
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Member since May 2011
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Study: fasting results in complex metabolic changes
quote:

In a paper published in January 2019 in the journal Scientific Reports, a team of researchers at Okinawa Institute of Science and Technology (OIST) and Kyoto University revealed some of the effects of fasting, which go way beyond just burning fat. By analyzing the blood of four young, healthy human participants after they fasted for 34 and 58 hours — whoa! — the team found 42 different substances whose levels increase while a person is fasting (as well as two that go down), only 14 of which scientists had previously detected in fasting humans. That means they discovered 30 substances the human body produces in large quantities during fasting that scientists didn’t know about.

The fact that the body produces all these compounds, write the researchers, indicates that fasting jumpstarts a whole lot more metabolic processes than scientists had ever realized, some of which may have significant health benefits, including antioxidative defense — which may explain its supposed anti-aging effects.

“We have been researching aging and metabolism for many years and decided to search for unknown health effects in human fasting,” the study’s first author Takayuki Teruya, Ph.D., a technician at OIST, said in a statement. “Contrary to the original expectation, it turned out that fasting induced metabolic activation rather actively.”

As a human is fasting, the body has to switch from using food for energy to using the energy that’s stored in the body, in the form of fat and glycogen. Flipping this switch, in turn, kicks off a whole bunch of other metabolic processes that result in the compounds measured in this study. These include well-known byproducts of fasting, like butyrates, acylcarnitines, and branched chain amino acids, as well as a host of other organic acids, coenzymes, antioxidants, purines, and pyrimidines, which, the team writes, “appear to implicate hitherto unrecognized metabolic mechanisms induced by fasting.”

While some of these compounds peaked in participants’ blood and plasma at the 34-hour mark, others continued to rise for the full 58-hour fast, reaching levels 60 times their normal concentrations in human blood.

The implications of these findings aren’t completely clear, as the study was small and didn’t track the participants’ long-term health over multiple fasts, but the researchers say they point to several potential benefits of fasting. In addition to antioxidative defense, which helps protect the body against some of the long-term damage associated with aging, the study’s authors argue that fasting appears to enhance activity in the mitochondria — the powerhouse of the cell.

Complicating the picture, the researchers write that the body may actually be producing some antioxidant compounds in response to the dangerous oxidative stress that fasting can cause in the first place.

One thing is abundantly clear, though: Fasting really changes the body.

“Since the 44 metabolites account for one-third of all blood metabolites detected, fasting clearly caused major metabolic changes in human blood,” write the researchers. With future studies, they hope to gain a clearer picture of how fasting affects the human body by recruiting more volunteers, lowering the chances that variations in metabolism will be due to individual differences.

But for now, it’s safe to say that fasting is nowhere near as simple as it seems, and scientists are only beginning to bring the full picture into focus.


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TigerNutts
LSU Fan
Louisiana
Member since Mar 2011
2365 posts

re: Study: fasting results in complex metabolic changes
Bold something


Hulkklogan
LSU Fan
Baton Rouge, LA
Member since Oct 2010
40125 posts

re: Study: fasting results in complex metabolic changes
TL;DR - Study finds 30 new substances that are generated when participants fasted for up to 58 hours. These could be involved in various metabolic pathways, which could have huge implications, but could also not mean much at all.

Beyond finding the new substances, the science is unknown. This is kind of kicking open 30 new doors and now there's much studying to be done to find out if there's anything revolutionary behind those doors.
This post was edited on 8/18 at 8:55 pm


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122
Athos
Missouri Fan
Member since Sep 2016
6917 posts

re: Study: fasting results in complex metabolic changes
Four participants in the study? Definitely the height of the scientific method there.


Junky
Valparaiso Fan
Louisiana
Member since Oct 2005
6174 posts

re: Study: fasting results in complex metabolic changes
quote:

Four participants in the study?


Doesn’t really matter that much in this context.


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42
FlyinTiger93
LSU Fan
Member since May 2010
1840 posts
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re: Study: fasting results in complex metabolic changes
58 hour fasting? I need a burger.


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SirWinston
LSU Fan
PNW
Member since Jul 2014
54153 posts

re: Study: fasting results in complex metabolic changes
Love fasting - life changing and so grateful. My testosterone has spiked dramatically and my shoulder inflammation is basically a non issue now thanks to the great Tommy Delauer’s IF and Keto programs and the great Tommy Brady’s hydration and pliability strategies
This post was edited on 8/20 at 10:23 am


el Gaucho
Southern Fan
bawcomville
Member since Dec 2010
42604 posts
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re: Study: fasting results in complex metabolic changes
Unfortunately the subjects gained weight because their bodies went into starvation mode


Lima Whiskey
Virginia Fan
Member since Apr 2013
10075 posts

re: Study: fasting results in complex metabolic changes
How did you implement fasting?


Lima Whiskey
Virginia Fan
Member since Apr 2013
10075 posts

re: Study: fasting results in complex metabolic changes
When I did keto that didn’t happen.

I actually had trouble keeping weight.


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Hulkklogan
LSU Fan
Baton Rouge, LA
Member since Oct 2010
40125 posts

re: Study: fasting results in complex metabolic changes
It's el gaucho




I think I've seen him make 2 serious posts the entire time he's been around.


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80
Lsu111519
Member since Apr 2020
44 posts

re: Study: fasting results in complex metabolic changes
You just have to start at 16 hours and go from there. Been doing it 6 months and its life changing. The first time I did it I ate and was almost sick and I couldnt eat for almost 18-20 hours and that's how I started. The first week or 2 were hard but it got easier. Now I do 24 hours a day almost every single day and 42-48 hours 1 day a week. You have to become fat adapted to keep you full longer and also get plenty of sleep.


razorbackfan4life
Chicago Cubs Fan
Northwest Arkansas
Member since Apr 2011
6936 posts

re: Study: fasting results in complex metabolic changes
I'm down about 15 lbs in a couple of months from fasting.

My acid reflux has gone away.

I've been sleeping better as well.

With that said I could be doing better with the type of foods I consume after my fast, but it obviously isn't hampering my weight loss.

Now if I could get my lazy arse into the gym, I would be better off.


Lunchbox48
Citadel Fan
Member since Feb 2009
837 posts

re: Study: fasting results in complex metabolic changes
Newb to IF here, can I have an eating window from 1-7pm and still lift/run at 5:30-7am? That’s honestly the only reasonable time to exercise I have, plus family dinner and not being a zombie at work before lunch are important to me.

The only reason I’ve never tried IF is because I assumed those factors would negate it as an realistic long term program for weight loss and management for me.


Huey Lewis
LSU Fan
BR
Member since Oct 2013
3507 posts

re: Study: fasting results in complex metabolic changes
quote:

Newb to IF here, can I have an eating window from 1-7pm and still lift/run at 5:30-7am? That’s honestly the only reasonable time to exercise I have, plus family dinner and not being a zombie at work before lunch are important to me.



Fasting purists would say not to do what I'm about to recommend, but whatever. I think you're totally fine lifting in the morning and having a protein shake afterwards and coffee from morning until lunch, then starting your food window at lunch time.




Lunchbox48
Citadel Fan
Member since Feb 2009
837 posts

re: Study: fasting results in complex metabolic changes
Protein shake wouldn’t end the fast? I could do that if true.


lattin1
LSU Fan
baton rouge
Member since May 2014
148 posts

re: Study: fasting results in complex metabolic changes
quote:

Love fasting - life changing and so grateful. My testosterone has spiked dramatically and my shoulder inflammation is basically a non issue now thanks to the great Tommy Delauer’s IF and Keto programs and the great Tommy Brady’s hydration and pliability strategies


Any fads you haven't jumped on yet?


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10
Cockopotamus
South Carolina Fan
Member since Jan 2013
15309 posts

re: Study: fasting results in complex metabolic changes
quote:

Protein shake wouldn’t end the fast?


It most definitely would.


Lunchbox48
Citadel Fan
Member since Feb 2009
837 posts

re: Study: fasting results in complex metabolic changes
quote:

It most definitely would.


Good to know. I am going to just give it a shot for a couple of weeks and see if I can handle it and not fall asleep in my office.


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OysterPoBoy
LSU Fan
City of St. George
Member since Jul 2013
20988 posts
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re: Study: fasting results in complex metabolic changes
Try a 7am-1pm window.


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