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3
Posted on 8/18/21 at 8:56 am to Salmon
quote:
Ivermectin creates super spreaders?
ISWYDT
Posted on 8/18/21 at 8:57 am to Salmon
quote:
Ivermectin creates super spreaders?
No, Ivermectin prevents the virus from replicating. The vaccine creates super spreaders.
Posted on 8/18/21 at 8:57 am to Salmon
quote:
Ivermectin creates super spreaders?
I don't believe "super spreaders" are even a thing. Someone has to explain that to me.
How can you have a "super" number of active virus particles in you body and not show symptoms?
Historically you are contagious when you show symptoms like fever. Contagious means you have a high probability of spreading the virus because you have a high number of active viral particles in your body. Seems like COVID has changed that thinking.
Theoretically I could have one active virus particle and spread it by touching, sneezing or whatever. Then another person could have billions of active virus particles and spread the virus the same way. Both infected someone so I guess both are super spreaders.
Posted on 8/18/21 at 8:58 am to Outside looking in
quote:fricking Baw science
No, Ivermectin prevents the virus from replicating. The vaccine creates super spreaders.
Posted on 8/18/21 at 9:00 am to lsupride87
quote:
quote:
No, Ivermectin prevents the virus from replicating. The vaccine creates super spreaders.
fricking Baw science
What is your theory on the mechanism for ivermectin?
Posted on 8/18/21 at 9:00 am to When in Rome
Nice find, really good example of how easy it is to manipulate data and the sample sizes of studies
Posted on 8/18/21 at 9:01 am to GumboPot
quote:
I don't believe "super spreaders" are even a thing. Someone has to explain that to me.
I agree with you that was just a new talking point among a certain demographic
Posted on 8/18/21 at 9:02 am to GumboPot
quote:That it doesnt prevent viral replication
What is your theory on the mechanism for ivermectin?
Wish it did
This post was edited on 8/18/21 at 9:03 am
Posted on 8/18/21 at 9:04 am to lsupride87
quote:
fricking Baw science
To be fair, I posted this earlier from another study.
quote:
IVERMECTIN prevents viral entry into the nucleus of the cells.
The virus attaches on a heterodimer protein Importin a / Importin ß-1 which serves as a transport system in order for it to gain entry into the nucleus. Then the virus shuts down the nucleus thereby immune responses against it is practically suppressed. IVERMECTIN inhibits this heterodimer protein and the virus is prevented from latching onto it and is thus prevented from being transported into the nucleus, thereby disabling the virus from performing this critical function.
Posted on 8/18/21 at 9:04 am to lsupride87
quote:
Another one of the controlled studies used to show that Ivermectin had a 70% improvement in covid mortality
1/47 deaths in Ivermectin group and 3/42 deaths in control group
I mean honestly what is the point of studies this small?
The largest study in the control group is 1200 total people
18/677 deaths in ivermectin group and 22/678 deaths in control group
Well that's why they do the meta analysis. Sure it's imperfect, but when you aggregate the studies it shows that there is likely a benefit.
quote:
I guess I could clarify
Less than 50% of the studies showed in the OP are controlled. However, in the controlled studies, Ivermectin showed the least success compared to studies without control groups, and didnt show material differences from the control group itself as a whole
quote:
Studies Prophylaxis Early treatment Late treatment Patients Authors
All studies 63 86% [75-92%] 72% [55-82%] 40% [24-52%] 26,422 613
Peer-reviewed 42 86% [73-93%] 75% [61-84%] 43% [21-59%] 16,455 436
Randomized Controlled Trials 31 84% [25-96%] 61% [46-71%] 30% [2-50%] 6,561 359
Percentage improvement with ivermectin treatment
Percent improvement of 84% with prophylaxis and 64% with early treatment is not insignificant.
I'm not saying ivermectin is the answer, but I don't know why you want to discredit this study so much. I think it provides a solid data point that should be considered.
Posted on 8/18/21 at 9:04 am to Ingeniero
I love how you people pretend that the covid response isn't killing people. 10s-100's of thousands of people are going to die from missed cancer screenings and needed surgeries. Not to mention the suicides, ids etc. This is just like the war on terror, waste trillions and ruin millions of lives by overeacting
Posted on 8/18/21 at 9:06 am to stout
Is ivmmeta.com a non biased site?
Posted on 8/18/21 at 9:07 am to RC
quote:Im not trying to be rude, but for anyone with statistic sampling in their background, the controlled studies are completely useless
but I don't know why you want to discredit this study so much. I think it provides a solid data point that should be considered.
The size of the sample, and then the results of the control groups compared to general pop are off the wall outside the range
Posted on 8/18/21 at 9:08 am to macjonesgoat
quote:
I love how you people pretend that the covid response isn't killing people.
who are you people?
quote:
10s-100's of thousands of people are going to die from missed cancer screenings and needed surgeries. Not to mention the suicides, ids etc.
wasn't there no significant increase in deaths last year?
Posted on 8/18/21 at 9:09 am to lsupride87
quote:
Without a very robust control group, any covid study is basically useless. I’ll explain. If you treat 1000 people with fruity pebbles either as a prophylaxis or as a treatment once sick, 99.5% will have positive results
This
The problem with covid is that less than 5% of cases get hospitalized.
So depending on the group you choose, treat 100 covid pts early with ivermectin and only 2 get hospitalized you say “damn, that works great” but a control group might be exactly the same.
Posted on 8/18/21 at 9:09 am to stout
quote:
IVERMECTIN prevents viral entry into the nucleus of the cells.
Here is a youtube video explaining this:
Updated: Ivermectin Mechanism of Action (MOA) - More lectures on drbeen.com
Posted on 8/18/21 at 9:11 am to Cosmo
quote:The problem with these studies is the size of the control group
This
The problem with covid is that less than 5% of cases get hospitalized.
So depending on the group you choose, treat 100 covid pts early with ivermectin and only 2 get hospitalized you say “damn, that works great” but a control group might be exactly the same.
When your group sizes are 50 or 60, 1 or 2 patients going one way or the other shift your percentage in a huge swing
I dont think its a coincidence the controlled study with 1300 patients showed no material effect with ivermectin
Posted on 8/18/21 at 9:13 am to majoredinwhitehorse
This is such hyperbole I am so sick of this bs line
List me the virus we have successfully killed
List me the virus we have successfully killed
Posted on 8/18/21 at 9:15 am to macjonesgoat
quote:
I love how you people pretend that the covid response isn't killing people. 10s-100's of thousands of people are going to die from missed cancer screenings and needed surgeries. Not to mention the suicides, ids etc. This is just like the war on terror, waste trillions and ruin millions of lives by overeacting
I don't know if it is genuinely killing people, but I definitely think the impacts of overreaction are going to last decades. And I'm relatively pro-vax.
Now, whether or not we could have feasibly done it considerably better is a different debate. Some overreaction is probably the norm and I don't think comparing the reality to the ideal is useful. But especially this year onward, I think it becomes more credible to lay blame for negative consequences.
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