Is it possible to do Spain and Portugal Justice in two weeks?

It's been about 25 years, but we flew into Lisbon and left from Barcelona. I think we were close to three weeks driving and did Lisbon, The Algarve, Seville, Granada, Cordoba, Toledo, Madrid, Segovia, Barcelona and some places in between. Would like to go back and do more of the southern Spain coast.

It would be a whirlwind tour with just cursory glances at places to do both countries in 2 weeks. I have lived in Seville for the past 5 years and my recommendation would be to either spend that entire stretch in just Spain, or take at least 1 week in Portugal and the other week just in Barcelona, Seville and Madrid. Love Portugal, but you could do it justice in a week. Spain in a week is too tough and you would need to limit yourself to just 2 or 3 major areas.

That is some good information. Would there be any reference materials or websites or forums that connect us with people who go it alone and know Spain and Portugal for its beauty and culture w/o being touristy. We had liked the thought of Madeira in Portugal but not sure now that it has been discovered.

I have not been to that part of Portugal, so nothing first hand I can give on it = but, both Spain and Portugal have some great local government websites that are usually filled with info re places of interest to visit there. I'd start with that resource and then just do a deeper dive from it, if needed.

I guess I will be the contrarian here and say yes, but obviously can’t go as deep.
I have been to both Barcelona and Madrid for work with some built in time to explore. 2 full days in each place was more than sufficient, especially Barcelona. I would say that you should plan to “eat” your way across Spain as much as anything with regard to the regional variations in “tapas”. don’t say the word “Catalonia” in Madrid but do get the Crema Catalana in Barcelona. And because the Spanish eat so late, your body will be less effected by the time changes.
If you stroll La Rambla in Barcelona (shops and street vendors and markets), be aware of the extremely high risk of what colleagues described as professional pick pockets (all day) and highly aggressive prostitutes at night.
Obviously there are some trade offs, for instance walking around the outside of the Gaudi basilica vs standing in the absolute absurd lines to go inside is the difference of half a day. The hop on, hop off open buses with tour guides are good from what I was told to get a quick view of the high points. Do a dinner and watch Flamenco dancing in Madrid for more authentic.
I have yet to get to Portugal but have been told Lisbon is incredible and affordable. Plan to go home with more checked bags than you came with from your shopping.
Enjoy the trip and “Visca Catalunya!”