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Can significant weight loss change your brain chemistry?

Posted on 2/7/26 at 1:35 pm
Posted by BOSCEAUX
Where the Down Boys go.
Member since Mar 2008
51756 posts
Posted on 2/7/26 at 1:35 pm
Between September of ‘24 and March of ‘25 I lost 75 pounds and have kept it off with proper diet and exercise. I’m now 6’1” and 180 and feel great. I have noticed that my mind tends to “obsess” over certain things now and my interests have changed some. Kind of feels like what I’ve read a mid-life crisis is. Not a fan of this.
Posted by TheGeauxt9
South Louisiana
Member since May 2021
559 posts
Posted on 2/7/26 at 1:59 pm to
You probably obsess over things that keep you in a maintenance mindset, also that was more than likely one of the best decisions youve ever made for yourself by starting that journey, congrats baw
Posted by Dadren
Jawja
Member since Dec 2023
3221 posts
Posted on 2/7/26 at 2:04 pm to
quote:

I have noticed that my mind tends to “obsess” over certain things now and my interests have changed some.

Indirectly, maybe? I’d guess the direct cause is probably more diet/hormone related. “Feel good foods” do just what they say they do. But I’m guessing you’ll normalize if you stay with it.

And, congrats and good on ya!
This post was edited on 2/7/26 at 2:07 pm
Posted by W2NOMO
Member since Jul 2025
2123 posts
Posted on 2/7/26 at 2:06 pm to
Yes. It can make you more mindful of mortality. Being obese carries a lot of food noises in the consciousness.
Posted by theunknownknight
Baton Rouge
Member since Sep 2005
60516 posts
Posted on 2/7/26 at 2:08 pm to
Yes. Basic endocrinology confirms this
Posted by sgallo3
Lake Charles
Member since Sep 2008
25963 posts
Posted on 2/7/26 at 2:10 pm to
if you are using GLPs like Ozempic it absolutely will.
Posted by LSUDad
Still on the move
Member since May 2004
62186 posts
Posted on 2/7/26 at 2:14 pm to
quote:

Ozempic


In Mexico they have this in pill form.
$119.95/100 pills, the 3mg.
7mg/100 pills, $149.95
Posted by CocomoLSU
Inside your dome.
Member since Feb 2004
155762 posts
Posted on 2/7/26 at 2:22 pm to
I’m down ~40 lbs or so since about July. My mind isn’t any different, but it’s definitely noticeable how much better I feel these days. When I play sports, for example, I’ll be sweating my arse off yet not feel winded or out of breath at all really. It’s nice.

Even had to start using lower belt holes as well. Had to create a new one a few days ago.

I don’t really have a goal weight, as mine was more of a lifestyle change I was going for more than anything else. I don’t “eat healthy,” so mine is more a mix of eating less unhealthy, some fasting, and doing a few workout/exercise type things (the ole Walton & Johnson “eat less, move around more”). I’ve found a few things that I like and try to stick with it. And it’s working decently so far. I did lose 20 lbs very quickly and then plateaued. But I finally pushed through and lost more in the last month or two.
Posted by N2cars
Member since Feb 2008
38501 posts
Posted on 2/7/26 at 2:27 pm to
I lost 30 in a period of about six-seven months, not on purpose. Looked like hell, which was where I was.

Do not recommend.
Posted by BOSCEAUX
Where the Down Boys go.
Member since Mar 2008
51756 posts
Posted on 2/7/26 at 3:00 pm to
The funny thing is me and the wife did this together. The weight loss and being in better shape pushed my sex drive into hyperdrive, the weight loss and exercise pushed the wife into menopause. Life can be cruel
Posted by Marco Esquandolas
Member since Jul 2013
11709 posts
Posted on 2/7/26 at 3:15 pm to
Hopefully Mingo will chime in and give us his expert opinion…

Posted by BOSCEAUX
Where the Down Boys go.
Member since Mar 2008
51756 posts
Posted on 2/7/26 at 3:19 pm to
quote:

Hopefully Mingo will chime in and give us his expert opinion…


Posted by Bullfrog
Running Through the Wet Grass
Member since Jul 2010
60717 posts
Posted on 2/7/26 at 3:34 pm to
Congrats to all you skinny jean wearing dudes.

6’1” standing flat-footed in my old crocs. Was doing good until King Cakes started showing up everywhere.

I think my BMI actually got close to 30 and it’s gone back up now. Once Fat Tuesday is gone, I’ll try to get back on that pain train.

Why does no one make a Honey Bun King Cake? That would the the death of me.
Posted by Sun God
Member since Jul 2009
50922 posts
Posted on 2/7/26 at 4:32 pm to
Posted by TheRealTigerHorn
Member since Jun 2023
298 posts
Posted on 2/7/26 at 5:26 pm to
quote:

In Mexico they have this in pill form.
$119.95/100 pills, the 3mg.
7mg/100 pills, $149.95


Yes, and the state of Texas will tell you that they get regular emergency calls over these pills being contaminated with oleander, a deadly poison.
Posted by TigerGman
Center of the Universe
Member since Sep 2006
13666 posts
Posted on 2/7/26 at 5:29 pm to
quote:

if you are using GLPs like Ozempic it absolutely will.


Nice link to absolutely will.
Posted by LemmyLives
Texas
Member since Mar 2019
14243 posts
Posted on 2/7/26 at 6:03 pm to
If you used food as a coping mechanism for some sort of anxiety, and you've taken that method of coping away, your body may be looking for other ways to create the same effect. In many cases, the exercise becomes that coping mechanism, but it doesn't seem to for you. But the coping mechanism is the symptom of a different problem.

What is underneath the anxiety you don't realize you have? Job? Family? Finances? Explore the stressors you think you're dealing with, and figure out if you really are.
Posted by U
Member since Jun 2013
71 posts
Posted on 2/7/26 at 6:29 pm to
Yes fat is estrogenic
Posted by BOSCEAUX
Where the Down Boys go.
Member since Mar 2008
51756 posts
Posted on 2/7/26 at 6:36 pm to
Not finances we are very comfortable. Newly empty nesters so maybe that. I don’t know my brain is on fire.
Posted by T1gerNate
Member since Feb 2020
2889 posts
Posted on 2/7/26 at 6:52 pm to
That thing you’re feeling is the call to greatness. Embrace it.
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