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New drug wipes out 94% of harmful cholesterol with A SINGLE DOSE in trials, lasts a year
Posted on 4/6/25 at 6:01 am
Posted on 4/6/25 at 6:01 am
drug is called Lepidisiran, and it entered phase 3 of drug trials on March 31
From the Wiki:
This could be a monumental gamechanger, Wonder what the side effects down the road will be?
LINK
From the Wiki:
quote:
Lepodisiran (LY3819469) is a small interfering RNA that was developed to reduce lipoprotein(a) in people at risk of cardiovascular disease. It was developed by Eli Lilly and Company.
As of March 31 of 2025, company trials in phase 2 of randomized, double-blind, placebo-controlled study resulted in significant reduction by the lepodisiran levels of genetically inherited cardiovascular risk factor such as heart attacks, strokes, thrombosis, nearly 94% from baseline.
This could be a monumental gamechanger, Wonder what the side effects down the road will be?
LINK
This post was edited on 4/7/25 at 5:50 am
47
Posted on 4/6/25 at 6:04 am to Roaad
Tariffs
Posted on 4/6/25 at 6:08 am to canyon
and EgGs…. no, wait….. damn!
Posted on 4/6/25 at 6:08 am to TigahTeeth
Lol
Posted on 4/6/25 at 6:09 am to Roaad
quote:
Lepodisiran (LY3819469) is a small interfering RNA
And for this reason, the Covidtards are out.
Posted on 4/6/25 at 6:11 am to Stevo
quote:Who's that?
Covidtards.
Posted on 4/6/25 at 6:12 am to Roaad
Does it wipe out all the cholesterol in the brain leading to stupidity?
Posted on 4/6/25 at 6:14 am to Roaad
What about the good cholesterol
Posted on 4/6/25 at 6:15 am to Pelican fan99
quote:
What about the good cholesterol
there are lots of new articles on it the past week
Posted on 4/6/25 at 7:13 am to Stevo
quote:
And for this reason, the Covidtards are out.
Remind us, who were the “tards” when in came to Covid and the so-called vaccine?
Posted on 4/6/25 at 7:16 am to SloaneRanger
You'll have to translate that sentence for me first.
Posted on 4/6/25 at 7:52 am to Stevo
How many boosters for you now?
Posted on 4/6/25 at 7:53 am to Roaad
There are no pharmaceutical "shortcuts" to good health. BigPharma is not in the business of making you healthier. They are in the business of keeping you sick and keeping you as a customer.
Posted on 4/6/25 at 7:55 am to Roaad
And the side effects will be terrible.
“We knocked out the bad cholesterol but you’re guaranteed dementia in 6-8 years!”
“We knocked out the bad cholesterol but you’re guaranteed dementia in 6-8 years!”
Posted on 4/6/25 at 8:03 am to Roaad
It never gonna work that simple.
There will always be side effects.
You have to clean up your diet and move more. There is no magic trick to it. Stop eating so much processed foods and sugar.
Without exercise, your body starts to deteriorate as you age because you stop moving
There will always be side effects.
You have to clean up your diet and move more. There is no magic trick to it. Stop eating so much processed foods and sugar.
Without exercise, your body starts to deteriorate as you age because you stop moving
Posted on 4/6/25 at 8:17 am to Fat and Happy
quote:
There will always be side effects
Wow! Are you in Mensa?
Kidding, all drugs have side effects (free radicals).
Aspirin is considered a miracle drug because it does a lot of things well for most people, with minimal side effects.
Lifestyle changes are important as you mentioned, but for some those changes aren't enough, and they need pharmaceutical help.
I would strongly encourage anyone that is that concerned about side effects, and that is so fearful, to immediately throw all their OTC and prescription medications in the garbage.
Do it now, quickly!
Posted on 4/6/25 at 8:23 am to Roaad
Same thing happened with Repatha. Investors got a huge boner, but the decrease in cardiac events were not linear. They were able to get cholesterol into single digits, but just mild reduction in events,
For those already with CAD a reduction of events 11.3% compared to placebo of 9.8% so 1.5 ARR and 15% RRR which is enough for a pharma co. to sink 2-3 billion!!! into.
NNT is that you have to treat 147 people for 1 years to stop one event. There were no decrease in cardiac deaths, which could take more than the two years that the patients were followed.
One percent risk reduction can be argued is a very successful drug because if you take 10 of them, you now have reduced your risk by 10% lol
If we extrapolate this data,If all of the 12.5 million people Who have heart disease in the country take Repath for 20 years, you could reduce 1.3 million heart attacks.
For those already with CAD a reduction of events 11.3% compared to placebo of 9.8% so 1.5 ARR and 15% RRR which is enough for a pharma co. to sink 2-3 billion!!! into.
NNT is that you have to treat 147 people for 1 years to stop one event. There were no decrease in cardiac deaths, which could take more than the two years that the patients were followed.
One percent risk reduction can be argued is a very successful drug because if you take 10 of them, you now have reduced your risk by 10% lol
If we extrapolate this data,If all of the 12.5 million people Who have heart disease in the country take Repath for 20 years, you could reduce 1.3 million heart attacks.
This post was edited on 4/6/25 at 8:50 am
Posted on 4/6/25 at 8:33 am to Roaad
quote:quote:.
Covidtards
Who's that?
Posted on 4/6/25 at 8:36 am to Roaad
Yeah...
Gonna need some long term studies in this one
Gonna need some long term studies in this one
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