- My Forums
- Tiger Rant
- LSU Recruiting
- SEC Rant
- Saints Talk
- Pelicans Talk
- More Sports Board
- Winter Olympics
- Fantasy Sports
- Golf Board
- Soccer Board
- O-T Lounge
- Tech Board
- Home/Garden Board
- Outdoor Board
- Health/Fitness Board
- Movie/TV Board
- Book Board
- Music Board
- Political Talk
- Money Talk
- Fark Board
- Gaming Board
- Travel Board
- Food/Drink Board
- Ticket Exchange
- TD Help Board
Customize My Forums- View All Forums
- Topic Sort Options
- Trending Topics
- Recent Topics
- Active Topics
Knuckle Checker
| Favorite team: | |
| Location: | |
| Biography: | |
| Interests: | |
| Occupation: | |
| Number of Posts: | 628 |
| Registered on: | 1/27/2019 |
| Online Status: | Not Online |
Forum
Message
Obama deported 2 US citizens
Posted by Knuckle Checker on 2/10/26 at 9:49 pm
Oh it gets better….
One was a 14 year old child. Jakadrien Turner.
The other was A PREGNANT MOTHER.
Maria Ramos.
Why is this not common knowledge?
Why were there no protests?
Can you fricking imagine if Trump deported a pregnant female?
frick the fake news media for fueling this charade.
One was a 14 year old child. Jakadrien Turner.
The other was A PREGNANT MOTHER.
Maria Ramos.
Why is this not common knowledge?
Why were there no protests?
Can you fricking imagine if Trump deported a pregnant female?
frick the fake news media for fueling this charade.
re: This is a good this is a good article on seed oils It has corporate greed, AMA, and ….
Posted by Knuckle Checker on 2/7/26 at 4:08 pm to awestruck
quote:
Yep, ask your AI again specifying non-industry independent studies only. Same question(s) as before but using only "Independent Studies". And then grace again with your presence.... please!
Well that’s a convenient shift of the goal posts.
So you think the “industry” has faked all of these genetic studies?
If we are using your standards why don’t you post the non industry funded studies that say LDL doesn’t cause heart disease
re: This is a good this is a good article on seed oils It has corporate greed, AMA, and ….
Posted by Knuckle Checker on 2/7/26 at 8:04 am to ruzil
I’d also like to add that there is more evidence that LDL causes heart disease than there is that smoking causes lung cancer and I’m sure you wouldn’t dispute that.
Now we all know someone who smoked 2 packs a day for 50 years and lived to 95 without lung cancer. So the stories of “my grandpa cooked in bacon fat his whole life and lived to 95” are pretty irrelevant. There are always outliers due to genetic factors and luck.
I understand that there is money and influence in medicine. There is also money and influence in instagram grifting. So don’t fall for the last Instagram grift.
Now we all know someone who smoked 2 packs a day for 50 years and lived to 95 without lung cancer. So the stories of “my grandpa cooked in bacon fat his whole life and lived to 95” are pretty irrelevant. There are always outliers due to genetic factors and luck.
I understand that there is money and influence in medicine. There is also money and influence in instagram grifting. So don’t fall for the last Instagram grift.
re: This is a good this is a good article on seed oils It has corporate greed, AMA, and ….
Posted by Knuckle Checker on 2/7/26 at 7:40 am to ruzil
Just to put some of this in layman’s terms…. Mendelian randomization means they used genetics to prove LDL is bad since diets and peoples reporting of their diets can vary so much.
Some people have random mutations that cause naturally higher LDL no matter what they eat. Some people have extremely low or nonexistent LDL no matter what they eat.
They organized these people by their LDL genetics and it turns out that as your LDL genetics get worse so does your risk for heart disease.
It’s one of the most reliable ways to determine causation in medicine.
Do you have any questions?
Some people have random mutations that cause naturally higher LDL no matter what they eat. Some people have extremely low or nonexistent LDL no matter what they eat.
They organized these people by their LDL genetics and it turns out that as your LDL genetics get worse so does your risk for heart disease.
It’s one of the most reliable ways to determine causation in medicine.
Do you have any questions?
re: This is a good this is a good article on seed oils It has corporate greed, AMA, and ….
Posted by Knuckle Checker on 2/7/26 at 7:36 am to Knuckle Checker
3) Drug-target genetics (PCSK9 / LDLR variants)
Schmidt AF et al.
Phenome-wide association analysis of LDL-cholesterol-lowering genetic variants in PCSK9.
BMC Cardiovascular Disorders (2019).
• Used naturally occurring LDL-lowering gene variants.
• Showed that genetically lowered LDL is associated with reduced cardiovascular disease phenotypes.
• Helped validate PCSK9 inhibition as a therapeutic target. ?
?
4) Modern large-scale two-sample MR studies (replication era)
Example:
Two-sample MR metabolite study (2025)
• Used GWAS datasets (~86k CHD cases).
• Found genetically higher LDL cholesterol fractions associated with increased CHD risk (OR ~1.7–2.2 depending on LDL subtype).
Schmidt AF et al.
Phenome-wide association analysis of LDL-cholesterol-lowering genetic variants in PCSK9.
BMC Cardiovascular Disorders (2019).
• Used naturally occurring LDL-lowering gene variants.
• Showed that genetically lowered LDL is associated with reduced cardiovascular disease phenotypes.
• Helped validate PCSK9 inhibition as a therapeutic target. ?
?
4) Modern large-scale two-sample MR studies (replication era)
Example:
Two-sample MR metabolite study (2025)
• Used GWAS datasets (~86k CHD cases).
• Found genetically higher LDL cholesterol fractions associated with increased CHD risk (OR ~1.7–2.2 depending on LDL subtype).
re: This is a good this is a good article on seed oils It has corporate greed, AMA, and ….
Posted by Knuckle Checker on 2/7/26 at 7:35 am to ruzil
Sure I asked ChatGPT to help…
1) Early landmark MR evidence (2012–2014 era)
Holmes MV et al.
Mendelian randomization of blood lipids for coronary heart disease.
European Heart Journal (2014).
• Used SNPs affecting LDL, HDL, triglycerides across 17 studies (~62k participants, ~12k CHD events).
• Found genetic variants that raise LDL were associated with higher CHD risk, supporting causality.
• HDL did not show the same causal signal.
• This paper is widely cited as one of the major modern MR demonstrations for LDL ? CHD.
• PubMed entry:
Evidence summary: weighted allele scores for LDL-related variants were significantly associated with coronary heart disease outcomes. ?
?
2) Lifelong LDL exposure study (a very influential MR analysis)
Ference BA et al.
Effect of long-term exposure to lower LDL cholesterol beginning early in life on the risk of coronary heart disease.
Journal of the American College of Cardiology (2012).
• Meta-analysis of genetic variants that naturally lower LDL from birth.
• Found large reductions in CHD risk proportional to lifelong LDL lowering.
• Often cited as key genetic support for the LDL causal hypothesis.
(Excerpt summarized from study data):
• Each ~1 mmol/L lower LDL from genetic variants linked to roughly ~50% lower CHD risk. ?
1) Early landmark MR evidence (2012–2014 era)
Holmes MV et al.
Mendelian randomization of blood lipids for coronary heart disease.
European Heart Journal (2014).
• Used SNPs affecting LDL, HDL, triglycerides across 17 studies (~62k participants, ~12k CHD events).
• Found genetic variants that raise LDL were associated with higher CHD risk, supporting causality.
• HDL did not show the same causal signal.
• This paper is widely cited as one of the major modern MR demonstrations for LDL ? CHD.
• PubMed entry:
Evidence summary: weighted allele scores for LDL-related variants were significantly associated with coronary heart disease outcomes. ?
?
2) Lifelong LDL exposure study (a very influential MR analysis)
Ference BA et al.
Effect of long-term exposure to lower LDL cholesterol beginning early in life on the risk of coronary heart disease.
Journal of the American College of Cardiology (2012).
• Meta-analysis of genetic variants that naturally lower LDL from birth.
• Found large reductions in CHD risk proportional to lifelong LDL lowering.
• Often cited as key genetic support for the LDL causal hypothesis.
(Excerpt summarized from study data):
• Each ~1 mmol/L lower LDL from genetic variants linked to roughly ~50% lower CHD risk. ?
re: This is a good this is a good article on seed oils It has corporate greed, AMA, and ….
Posted by Knuckle Checker on 2/6/26 at 6:59 pm to rltiger
Here’s the problem. Most people hear that crisco is bad and think that means bacon fat and butter is good. That’s bad logic.
There is indisputable evidence that high cholesterol causes heart disease. Like very clear studies of people with mutations that cause high cholesterol regardless of diet (they get severe heart disease) and people with mutations that cause low cholesterol (they have no heart disease)
Or studies of remote tribes who have LDL cholesterol levels of like 30 and they have very little heart disease.
Bacon fat and butter increase cholesterol
There is indisputable evidence that high cholesterol causes heart disease. Like very clear studies of people with mutations that cause high cholesterol regardless of diet (they get severe heart disease) and people with mutations that cause low cholesterol (they have no heart disease)
Or studies of remote tribes who have LDL cholesterol levels of like 30 and they have very little heart disease.
Bacon fat and butter increase cholesterol
re: A UK jury let 6 pro-Palestinian activists walk after they broke into a weapons factory.
Posted by Knuckle Checker on 2/4/26 at 7:56 pm to TrueTiger
This is what happens when your police force has only non lethal means. A taser couldn’t even subdue a female blue hair weirdo and everything turns in to a wrestling match and an officer has a broken spine.
Let this be a lesson for the de escalation folks.
Let this be a lesson for the de escalation folks.
re: Who has ICE arrested that shouldn't have been?
Posted by Knuckle Checker on 2/1/26 at 7:22 am to Big Scrub TX
quote:
It's John Lott, so you have to take it with a grain of salt. He is definitely doing some apples and oranges stuff in there. I wanted to believe it all, but when I looked into it a bit, I'm not so sure.
Where did you look into it and what did you find? Genuinely curious.
re: So did Pretti’s gun go off in the agent’s hand or not?
Posted by Knuckle Checker on 1/25/26 at 9:51 am to Sp0728
quote:
Citizens have a 2A right. He did not pull it out or threaten to use it.
The second amendment doesn’t give you the right to resist arrest and wrestle with the cops with your firearm.
He didn’t get shot because he had a gun.
He got shot because he had a gun AND was wrestling with the cops.
It’s a big fricking difference that you conveniently leave out.
AI and Tigerdroppings
Posted by Knuckle Checker on 1/22/26 at 4:13 pm
Hypothetical question, one day will AI be good enough to look at a poster with say 20,000 posts and continue to post like them after they die and no one know any better?
Some of you may be able to live on forever on TD….
Some of you may be able to live on forever on TD….
re: Indiana average age is 24 years old.
Posted by Knuckle Checker on 1/19/26 at 9:28 pm to Portcityblues
Not to mention they probably don’t even have to go to class.
Can spend all day training and studying tape
Can spend all day training and studying tape
re: So far, we got 8 OL in the portal. Lost a few.
Posted by Knuckle Checker on 1/18/26 at 2:49 pm to Lester Earl
quote:
Lester Earl
Just likes to play the contrarian because he thinks it makes him look smart
Better talent left? Based on what, recruiting stars, height, weight?
Surely you can’t mean game film. I don’t care if they “showed flashes”. For every decent block you show me I can find you 5 where they look like it’s the first time they have ever played a down of football.
re: Historical polar motion... has fully ended
Posted by Knuckle Checker on 1/1/26 at 9:55 am to SquatchDawg
Ethical skeptic is a clown
After COVID he had all these projections and fancy graphs showing how there would be a global famine and millions would die.
Nothing happened.
Rinse and repeat
After COVID he had all these projections and fancy graphs showing how there would be a global famine and millions would die.
Nothing happened.
Rinse and repeat
Cleaning lump crab meat
Posted by Knuckle Checker on 12/27/25 at 11:12 am
Is there a secret to cleaning the shells out of crab meat? I sit there and pick through it all and it’s a pain in the arse and ineviteably there are still some shells that people almost choke on. Am I unrealistic to think that a $50 container of lump crab meat should have less shells in it?
re: Fulton County admits they did not follow the rules.
Posted by Knuckle Checker on 12/22/25 at 11:10 am to SlowFlowPro
quote:
Due to the clerical error
Isn’t that what they arrested Trump for?
re: Corn and crab bisque question
Posted by Knuckle Checker on 12/17/25 at 9:24 am to Y.A. Tittle
quote:
The heads can make it both look and taste a bit “muddy.”
Is the same thing true for parts of the crab?
I would put whole gumbo crabs in the stock as well. Should I use only certain parts of the crab if I want a less “muddy” stock?
re: Corn and crab bisque question
Posted by Knuckle Checker on 12/16/25 at 9:05 pm to Y.A. Tittle
Hmmm that’s interesting. I was putting the heads in too
Corn and crab bisque question
Posted by Knuckle Checker on 12/16/25 at 6:43 pm
I make a corn and crab bisque every year but I haven’t been thrilled with the shrimp and crab stocks I’ve made. I want to use a premade lobster stock. Has anyone ever done that or have another recommendation for a premade stock? I’m thinking the lobster stock may be sweeter and more flavorful.
The shrimp and crab stocks I’ve made are kind of murky (best way I can describe it)
The shrimp and crab stocks I’ve made are kind of murky (best way I can describe it)
Best Turkey Injection Recipe for Frying
Posted by Knuckle Checker on 11/24/25 at 6:54 pm
I’m frying a turkey in oil and looking for a good recommendation for an injection marinade recipe.
Whatcha got?
Whatcha got?
re: Clarion Ledger: I did hot yoga with Lane Kiffin
Posted by Knuckle Checker on 11/21/25 at 11:02 am to St8lyOaks
And then Lane said, “I’ll show you something harder”
re: Pivot Year Day 225
Posted by Knuckle Checker on 11/19/25 at 7:41 pm to Shotgun Willie
I’ll hold you Lane
re: What do local insurance agents actually do?
Posted by Knuckle Checker on 11/13/25 at 6:43 pm to Giantkiller
This is one industry I hope AI kills.
Totally worthless
Totally worthless
re: Yay. It’s completely dark at 6pm. Yay.
Posted by Knuckle Checker on 11/3/25 at 6:13 pm to Prodigal Son
Day light is not being saved.
It’s being wasted.
It’s being wasted.
re: Just pay more and eliminate buyout
Posted by Knuckle Checker on 10/27/25 at 4:36 pm to SlidellCajun
Well we essentially paid more than $25 million per year for Brian Kelly.
You may have a point.
When I put it that way I want to vomit.
You may have a point.
When I put it that way I want to vomit.
re: The “You’re Spoiled” comment by Kelly to Reporters
Posted by Knuckle Checker on 10/22/25 at 7:38 am to tigerbait3488
The man who makes $10 million dollars a year wether he wins or loses a kids game calling people who make meager wages working a 9 to 5 spoiled is peak insanity
re: Dear BK and Joe
Posted by Knuckle Checker on 10/20/25 at 12:31 pm to Koplan16
This shite is straight from Chat GPT
re: LSU Northgate-Highland/HBCU Homecoming shootings explained
Posted by Knuckle Checker on 10/12/25 at 11:17 am to IMJ127
quote:
Why do you think good black people have to do something about a subculture we don't associate with? Just because you categorize black culture singularly doesn't mean it is. Stop lumping us in with all the other bullshite. We don't know, relate, or gaf about that group of individuals just as you don't about the degenerates in your culture.
I get what you are saying, there is definitely a white trash subculture.
BUT here is the difference. They aren’t committing 50% of the murders and violent crime in this country and single handedly destroying cities.
I can guarantee you if a small subculture of white people were doing that we would vote to change it.
The question is why don’t good black people vote to change it?
re: Brad Davis Average Rushing YPG produced by his OL units over last 11 seasons
Posted by Knuckle Checker on 10/4/25 at 7:15 am to GetmorewithLes
quote:
I have been on this BDavis needs to go bandwagon too but your data above tells me problem is OC. Peetz was crap. Denbrock was pretty good. Sloan has been crap.
Maybe if you are just looking at the stats.
But from the eye test we can see when this team gets in short yardage situations they just can’t get any push.
It’s not always scheme. You still have to beat your man 1 on 1 and they can’t. Not even inferior opponents.
And they consistently show poor technique. It’s not the OCs job to teach them technique.
re: Evidence from Kyren Lacy Wreckless Case (HeartBreaking)
Posted by Knuckle Checker on 10/3/25 at 9:13 pm to root
quote:
The law is 100ft per the attorney in the video
Is this really true. You just have to be back in your lane 100 feet before the oncoming car?
If 2 cars are going 50mph or more, 100 feet isn’t even enough time to react to get back in your lane.
Did global warming end hurricanes?
Posted by Knuckle Checker on 9/28/25 at 8:06 pm
asking those who believe in global warming.
When we have more hurricanes it’s because of global warming. The past few years we haven’t had any. Is this because of global warming too?
When we have more hurricanes it’s because of global warming. The past few years we haven’t had any. Is this because of global warming too?
Popular
12












