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Knuckle Checker
| Favorite team: | |
| Location: | |
| Biography: | |
| Interests: | |
| Occupation: | |
| Number of Posts: | 642 |
| Registered on: | 1/27/2019 |
| Online Status: | Not Online |
Recent Posts
Message
re: Cut the McMahon bashing out
Posted by Knuckle Checker on 3/26/26 at 10:55 am to doya2
“You don’t lose 100% of the postseason games you don’t make”
- Matt McMahon
- Matt McMahon
1
re: Now that it's official McOver... share your favorite McMemory
Posted by Knuckle Checker on 3/26/26 at 10:26 am to BrohemAlem11
My favorite memory and stat is that he is undefeated in the postseason.
Mainly because he never made the postseason. You don’t lose 100% of the games you don’t play. That’s McGenius.
Mainly because he never made the postseason. You don’t lose 100% of the games you don’t play. That’s McGenius.
re: You could have spent 1 million dollars every single day since the year 1 AD..
Posted by Knuckle Checker on 3/20/26 at 4:45 pm to sgallo3
quote:
Who are you voting for that is reducing gov spending?
No one. That was my point. There is no politician running on lower spending because they know they can’t win. There are too many people on the dole. The rubicon has been crossed and will continue until the currency is completely worthless.
re: You could have spent 1 million dollars every single day since the year 1 AD..
Posted by Knuckle Checker on 3/20/26 at 4:39 am to FAT SEXY
It’s a self perpetuating disaster that can’t be stopped until it implodes.
If you allow people who don’t pay taxes to vote they will always vote to take more from people who do pay taxes. The politicians will give it to them because it’s how they get elected.
There is no end in sight until the whole system collapses. Modern monetary theory which says you can keep printing as much money as you want is all a bullshite scam.
If you allow people who don’t pay taxes to vote they will always vote to take more from people who do pay taxes. The politicians will give it to them because it’s how they get elected.
There is no end in sight until the whole system collapses. Modern monetary theory which says you can keep printing as much money as you want is all a bullshite scam.
re: German engineer earning 41k Euros turns down American job earning 350k, cites insurance
Posted by Knuckle Checker on 3/18/26 at 9:54 am to HailHailtoMichigan!
I’m still waiting for someone to tell me how free healthcare is free.
All it means is someone else will pay for it. Either people who actually pay taxes or another generation as we continue to devalue our currency by printing money.
All it means is someone else will pay for it. Either people who actually pay taxes or another generation as we continue to devalue our currency by printing money.
HVAC repair costs
Posted by Knuckle Checker on 3/13/26 at 12:52 pm
Has anyone had any work done recently?
What is a reasonable price for a whole new 3 ton system installed?
What about just an evaporator replacement?
I’ve gotten a quote for $12,000 for a new system or $7,000 for just an evaporator.
What is a reasonable price for a whole new 3 ton system installed?
What about just an evaporator replacement?
I’ve gotten a quote for $12,000 for a new system or $7,000 for just an evaporator.
re: Bring Home T-Pear
Posted by Knuckle Checker on 3/11/26 at 6:04 pm to Boboss504
quote:
What is the obsession for a mediocre coach
Mediocre would be a HUGE upgrade right now
re: What is the direct positive impact to the US for our actions in Iran?
Posted by Knuckle Checker on 3/3/26 at 10:18 am to theballguy
quote:
A lot less terrorism directed at us. Hope that helps.
I’m pretty sure more Americans deaths have occurred at the hands of Sunni extremists… you know the ones we are currently partnering with.
re: Call & Write your Congressman: Big Bend is no place for a border wall
Posted by Knuckle Checker on 2/26/26 at 8:49 pm to jclem11
quote:
I'm a proud American and an ardent supporter of our National Park system.
Then you should care about preserving our country and not destroying it with open borders. Look at Europe.
If there is no America there are no national parks.
re: Call & Write your Congressman: Big Bend is no place for a border wall
Posted by Knuckle Checker on 2/26/26 at 8:45 pm to jclem11
Good lord you are acting like a huge pussy
The park is over 1,200 square miles
Its larger than the state of Rhode island
You wouldn’t see the wall from 99% of the park
Stop falling for stupid political click bait
The park is over 1,200 square miles
Its larger than the state of Rhode island
You wouldn’t see the wall from 99% of the park
Stop falling for stupid political click bait
re: Epstein autopsy cited enlarged prostate, Epstein files hint he may have had it removed.
Posted by Knuckle Checker on 2/24/26 at 6:51 pm to sgallo3
How many of yall are going to go repeat this to everyone you know without even thinking critically about what is happening here.
The first response is a hypothetical question.
The lab test wording is on every lab test explaining certain results.
The first response is a hypothetical question.
The lab test wording is on every lab test explaining certain results.
re: POTUS orders agencies to begin process of identifying & releasing info on UFOs etc
Posted by Knuckle Checker on 2/19/26 at 7:58 pm to Fun Bunch
First page.
This needs a sticky
This needs a sticky
re: CWD questions
Posted by Knuckle Checker on 2/19/26 at 6:23 pm to mtb010
After reading this I think I’m just going to clean my own deer and if a deer looks a little sketchy get it tested before eating.
Like I said I don’t know much about this but just using logic it doesn’t make sense to me that this is something that has been around forever. It appears to steadily be spreading from areas with very high concentration to other areas and some areas don’t have any at all.
If it has been around forever I would expect it to be spread fairly evenly and then fluctuate in areas.
Like I said I don’t know much about this but just using logic it doesn’t make sense to me that this is something that has been around forever. It appears to steadily be spreading from areas with very high concentration to other areas and some areas don’t have any at all.
If it has been around forever I would expect it to be spread fairly evenly and then fluctuate in areas.
CWD questions
Posted by Knuckle Checker on 2/19/26 at 3:04 am
I’m new to hunting and wanted to get the boards thoughts on chronic wasting disease.
Is anyone concerned about eating deer meat with the levels of CWD we are seeing?
It is my understanding you can get the meat tested by LA wildlife but if you are having it processed somewhere the equipment most definitely could be infected since heat or sterilization doesn’t kill the prions.
I guess the only way to be 100% safe would be to have the meat tested and process it yourself.
How much of a pain in the arse is that?
Is anyone concerned about eating deer meat with the levels of CWD we are seeing?
It is my understanding you can get the meat tested by LA wildlife but if you are having it processed somewhere the equipment most definitely could be infected since heat or sterilization doesn’t kill the prions.
I guess the only way to be 100% safe would be to have the meat tested and process it yourself.
How much of a pain in the arse is that?
Obama deported 2 US citizens
Posted by Knuckle Checker on 2/10/26 at 9:49 pm
Oh it gets better….
One was a 14 year old child. Jakadrien Turner.
The other was A PREGNANT MOTHER.
Maria Ramos.
Why is this not common knowledge?
Why were there no protests?
Can you fricking imagine if Trump deported a pregnant female?
frick the fake news media for fueling this charade.
One was a 14 year old child. Jakadrien Turner.
The other was A PREGNANT MOTHER.
Maria Ramos.
Why is this not common knowledge?
Why were there no protests?
Can you fricking imagine if Trump deported a pregnant female?
frick the fake news media for fueling this charade.
re: This is a good this is a good article on seed oils It has corporate greed, AMA, and ….
Posted by Knuckle Checker on 2/7/26 at 4:08 pm to awestruck
quote:
Yep, ask your AI again specifying non-industry independent studies only. Same question(s) as before but using only "Independent Studies". And then grace again with your presence.... please!
Well that’s a convenient shift of the goal posts.
So you think the “industry” has faked all of these genetic studies?
If we are using your standards why don’t you post the non industry funded studies that say LDL doesn’t cause heart disease
re: This is a good this is a good article on seed oils It has corporate greed, AMA, and ….
Posted by Knuckle Checker on 2/7/26 at 8:04 am to ruzil
I’d also like to add that there is more evidence that LDL causes heart disease than there is that smoking causes lung cancer and I’m sure you wouldn’t dispute that.
Now we all know someone who smoked 2 packs a day for 50 years and lived to 95 without lung cancer. So the stories of “my grandpa cooked in bacon fat his whole life and lived to 95” are pretty irrelevant. There are always outliers due to genetic factors and luck.
I understand that there is money and influence in medicine. There is also money and influence in instagram grifting. So don’t fall for the last Instagram grift.
Now we all know someone who smoked 2 packs a day for 50 years and lived to 95 without lung cancer. So the stories of “my grandpa cooked in bacon fat his whole life and lived to 95” are pretty irrelevant. There are always outliers due to genetic factors and luck.
I understand that there is money and influence in medicine. There is also money and influence in instagram grifting. So don’t fall for the last Instagram grift.
re: This is a good this is a good article on seed oils It has corporate greed, AMA, and ….
Posted by Knuckle Checker on 2/7/26 at 7:40 am to ruzil
Just to put some of this in layman’s terms…. Mendelian randomization means they used genetics to prove LDL is bad since diets and peoples reporting of their diets can vary so much.
Some people have random mutations that cause naturally higher LDL no matter what they eat. Some people have extremely low or nonexistent LDL no matter what they eat.
They organized these people by their LDL genetics and it turns out that as your LDL genetics get worse so does your risk for heart disease.
It’s one of the most reliable ways to determine causation in medicine.
Do you have any questions?
Some people have random mutations that cause naturally higher LDL no matter what they eat. Some people have extremely low or nonexistent LDL no matter what they eat.
They organized these people by their LDL genetics and it turns out that as your LDL genetics get worse so does your risk for heart disease.
It’s one of the most reliable ways to determine causation in medicine.
Do you have any questions?
re: This is a good this is a good article on seed oils It has corporate greed, AMA, and ….
Posted by Knuckle Checker on 2/7/26 at 7:36 am to Knuckle Checker
3) Drug-target genetics (PCSK9 / LDLR variants)
Schmidt AF et al.
Phenome-wide association analysis of LDL-cholesterol-lowering genetic variants in PCSK9.
BMC Cardiovascular Disorders (2019).
• Used naturally occurring LDL-lowering gene variants.
• Showed that genetically lowered LDL is associated with reduced cardiovascular disease phenotypes.
• Helped validate PCSK9 inhibition as a therapeutic target. ?
?
4) Modern large-scale two-sample MR studies (replication era)
Example:
Two-sample MR metabolite study (2025)
• Used GWAS datasets (~86k CHD cases).
• Found genetically higher LDL cholesterol fractions associated with increased CHD risk (OR ~1.7–2.2 depending on LDL subtype).
Schmidt AF et al.
Phenome-wide association analysis of LDL-cholesterol-lowering genetic variants in PCSK9.
BMC Cardiovascular Disorders (2019).
• Used naturally occurring LDL-lowering gene variants.
• Showed that genetically lowered LDL is associated with reduced cardiovascular disease phenotypes.
• Helped validate PCSK9 inhibition as a therapeutic target. ?
?
4) Modern large-scale two-sample MR studies (replication era)
Example:
Two-sample MR metabolite study (2025)
• Used GWAS datasets (~86k CHD cases).
• Found genetically higher LDL cholesterol fractions associated with increased CHD risk (OR ~1.7–2.2 depending on LDL subtype).
re: This is a good this is a good article on seed oils It has corporate greed, AMA, and ….
Posted by Knuckle Checker on 2/7/26 at 7:35 am to ruzil
Sure I asked ChatGPT to help…
1) Early landmark MR evidence (2012–2014 era)
Holmes MV et al.
Mendelian randomization of blood lipids for coronary heart disease.
European Heart Journal (2014).
• Used SNPs affecting LDL, HDL, triglycerides across 17 studies (~62k participants, ~12k CHD events).
• Found genetic variants that raise LDL were associated with higher CHD risk, supporting causality.
• HDL did not show the same causal signal.
• This paper is widely cited as one of the major modern MR demonstrations for LDL ? CHD.
• PubMed entry:
Evidence summary: weighted allele scores for LDL-related variants were significantly associated with coronary heart disease outcomes. ?
?
2) Lifelong LDL exposure study (a very influential MR analysis)
Ference BA et al.
Effect of long-term exposure to lower LDL cholesterol beginning early in life on the risk of coronary heart disease.
Journal of the American College of Cardiology (2012).
• Meta-analysis of genetic variants that naturally lower LDL from birth.
• Found large reductions in CHD risk proportional to lifelong LDL lowering.
• Often cited as key genetic support for the LDL causal hypothesis.
(Excerpt summarized from study data):
• Each ~1 mmol/L lower LDL from genetic variants linked to roughly ~50% lower CHD risk. ?
1) Early landmark MR evidence (2012–2014 era)
Holmes MV et al.
Mendelian randomization of blood lipids for coronary heart disease.
European Heart Journal (2014).
• Used SNPs affecting LDL, HDL, triglycerides across 17 studies (~62k participants, ~12k CHD events).
• Found genetic variants that raise LDL were associated with higher CHD risk, supporting causality.
• HDL did not show the same causal signal.
• This paper is widely cited as one of the major modern MR demonstrations for LDL ? CHD.
• PubMed entry:
Evidence summary: weighted allele scores for LDL-related variants were significantly associated with coronary heart disease outcomes. ?
?
2) Lifelong LDL exposure study (a very influential MR analysis)
Ference BA et al.
Effect of long-term exposure to lower LDL cholesterol beginning early in life on the risk of coronary heart disease.
Journal of the American College of Cardiology (2012).
• Meta-analysis of genetic variants that naturally lower LDL from birth.
• Found large reductions in CHD risk proportional to lifelong LDL lowering.
• Often cited as key genetic support for the LDL causal hypothesis.
(Excerpt summarized from study data):
• Each ~1 mmol/L lower LDL from genetic variants linked to roughly ~50% lower CHD risk. ?
re: This is a good this is a good article on seed oils It has corporate greed, AMA, and ….
Posted by Knuckle Checker on 2/6/26 at 6:59 pm to rltiger
Here’s the problem. Most people hear that crisco is bad and think that means bacon fat and butter is good. That’s bad logic.
There is indisputable evidence that high cholesterol causes heart disease. Like very clear studies of people with mutations that cause high cholesterol regardless of diet (they get severe heart disease) and people with mutations that cause low cholesterol (they have no heart disease)
Or studies of remote tribes who have LDL cholesterol levels of like 30 and they have very little heart disease.
Bacon fat and butter increase cholesterol
There is indisputable evidence that high cholesterol causes heart disease. Like very clear studies of people with mutations that cause high cholesterol regardless of diet (they get severe heart disease) and people with mutations that cause low cholesterol (they have no heart disease)
Or studies of remote tribes who have LDL cholesterol levels of like 30 and they have very little heart disease.
Bacon fat and butter increase cholesterol
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