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Since POTUS is now taking HCQ (smart) let me explain the science of why HCQ works.
Posted on 5/18/20 at 4:47 pm
Posted on 5/18/20 at 4:47 pm
First hydroxychloroquine is a safer alternative to chloroquine. Structrually they are very similar except hydroxychloroquine has an alcohol group where chloroquine has a methal group (the top right side of each molecule). This makes hydroxychloroquine more water soluble thus allowing a higher rate of metabolism and less bio accumulation.
Both hydroxychloroquine and chloroquine are zinc-ionophores. Chloroquine Is a Zinc Ionophore. Hydroxychloroquine acts as an ionophore the same way as chloroquine.
What is an ionophore:
The cell wall of the epithelial cells that viruses infect are phospholipid membranes.
So what is HCQ transporting?
It is transporting the zinc ion: Z2+.
Why is that important?
Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture.
I understand this research was done in vitro however it does proved the concept of zinc-ionophores and the ability of RNA polymerase to function properly thus inhibiting the replication of viruses.
Zn+2 blocks step 4 below:
What is the role of azythromycin?
Azythromycin is an antibiotic to inhibit secondary infections. When secondary infections are quelled the immune system can apply its energy in other hot spots. I know the immune response is not linear however I believe the goal is for the immune system to eliminate the virus in low gear (eliminate a cytokine storm). HCQ is also an immuno-suppressant helping to keep the immune system to not spin out of control.
Both hydroxychloroquine and chloroquine are zinc-ionophores. Chloroquine Is a Zinc Ionophore. Hydroxychloroquine acts as an ionophore the same way as chloroquine.
What is an ionophore:
quote:
a substance which is able to transport particular ions across a lipid membrane in a cell.
The cell wall of the epithelial cells that viruses infect are phospholipid membranes.
So what is HCQ transporting?
It is transporting the zinc ion: Z2+.
Why is that important?
Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture.
quote:
Increasing the intracellular Zn(2+) concentration with zinc-ionophores like pyrithione (PT) can efficiently impair the replication of a variety of RNA viruses, including poliovirus and influenza virus. For some viruses this effect has been attributed to interference with viral polyprotein processing. In this study we demonstrate that the combination of Zn(2+) and PT at low concentrations (2 µM Zn(2+) and 2 µM PT) inhibits the replication of SARS-coronavirus (SARS-CoV) and equine arteritis virus (EAV) in cell culture. The RNA synthesis of these two distantly related nidoviruses is catalyzed by an RNA-dependent RNA polymerase (RdRp), which is the core enzyme of their multiprotein replication and transcription complex (RTC).
I understand this research was done in vitro however it does proved the concept of zinc-ionophores and the ability of RNA polymerase to function properly thus inhibiting the replication of viruses.
Zn+2 blocks step 4 below:
What is the role of azythromycin?
Azythromycin is an antibiotic to inhibit secondary infections. When secondary infections are quelled the immune system can apply its energy in other hot spots. I know the immune response is not linear however I believe the goal is for the immune system to eliminate the virus in low gear (eliminate a cytokine storm). HCQ is also an immuno-suppressant helping to keep the immune system to not spin out of control.
11
Posted on 5/18/20 at 4:49 pm to GumboPot
Trump was right all along and anyone who doubted him should be considered a threat to our national security. Trump is trying to save millions of lives and the libs want us all to burn in hell.
Simply put, the medicine works and the president has known that since day one.
Simply put, the medicine works and the president has known that since day one.
Posted on 5/18/20 at 4:49 pm to GumboPot
I’ll take your..... and Trump’s word for it.
Posted on 5/18/20 at 4:51 pm to BarnHater
quote:
Simply put, the medicine works and the president has known that since day one.
Every day doctor after doctor report success stories using HCQ/Az/Z2+. When will there be enough anecdotal stories to convince Fauci and CNN HCQ works?
Posted on 5/18/20 at 4:52 pm to GumboPot
Solid post, one quibble (and I used to post this about HCQ as well):
Technically, it should be considered an immuno-moderator - in that it boosts the immune system in some ways and slows it down in others.
The more "suppressive" effects are why it helps with auto-immune disorders like Lupus and RA. The "boosting" effort is why it may help some folks infected with the Wuhan flu.
quote:
HCQ is also an immuno-suppressant helping to keep the immune system to not spin out of control.
Technically, it should be considered an immuno-moderator - in that it boosts the immune system in some ways and slows it down in others.
The more "suppressive" effects are why it helps with auto-immune disorders like Lupus and RA. The "boosting" effort is why it may help some folks infected with the Wuhan flu.
Posted on 5/18/20 at 4:54 pm to Ace Midnight
quote:
Technically, it should be considered an immuno-moderator - in that it boosts the immune system in some ways and slows it down in others.
I like your description more.
Posted on 5/18/20 at 4:54 pm to GumboPot
It is also said that it interferes with attachment at ACE-2.
It is also said that it increases pH in endosomes where replication and assembly take place.
It is also has effect on inflammatory response, thus blunting the "cytokine storm" involving IL-1, IL-1b, IL-3, IL-6, interferon gamma, and tissue necrosis factor.
ETA: apologies, did not see the inclusion of some in your quote.
It is also said that it increases pH in endosomes where replication and assembly take place.
It is also has effect on inflammatory response, thus blunting the "cytokine storm" involving IL-1, IL-1b, IL-3, IL-6, interferon gamma, and tissue necrosis factor.
ETA: apologies, did not see the inclusion of some in your quote.
This post was edited on 5/18/20 at 4:56 pm
Posted on 5/18/20 at 4:55 pm to GumboPot
If I get the corona I want HCQ, will I be able to in Louisiana?
Posted on 5/18/20 at 4:57 pm to Pussykat
Holy boring science Batman!
Posted on 5/18/20 at 5:01 pm to GumboPot
Does this work specifically for COVID 19 or could other strains and other viruses be treated with this too?
This post was edited on 5/18/20 at 5:03 pm
Posted on 5/18/20 at 5:02 pm to IslandBuckeye
quote:
It is also said that it interferes with attachment at ACE-2.
I've read this. This may be occurring while HCQ is helping Z2+ across the cell wall and CV can cross the cell wall much more efficiently with ACE-2. So that is an added benefit to HCQ.
quote:
It is also said that it increases pH in endosomes where replication and assembly take place.
Well from basic chemistry the Zn2+ is going to attract 2 OH- ions. In the entering gradient the pH is going to be high. This may be the location and the molecular mechanism to neutralize RNA polymerase.
quote:
It is also has effect on inflammatory response, thus blunting the "cytokine storm" involving IL-1, IL-1b, IL-3, IL-6, interferon gamma, and tissue necrosis factor.
I have read that too. 
Posted on 5/18/20 at 5:03 pm to GumboPot
quote:when there is as much profit in it for them as the vaccine manufactured by the company they own stock in
When will there be enough anecdotal stories to convince Fauci and CNN HCQ works?
Posted on 5/18/20 at 5:05 pm to Pussykat
quote:
If I get the corona I want HCQ, will I be able to in Louisiana?
I've heard that Ochsner doctors have been prescribing it.
Posted on 5/18/20 at 5:06 pm to GumboPot
Cavuto told me I was gonna die, though
Posted on 5/18/20 at 5:06 pm to momentoftruth87
quote:
Does this work specifically for COVID 19 or could other strains and other viruses be treated with this too?
It should work on any virus that requires RNA polymerase to replicate.
Posted on 5/18/20 at 5:15 pm to GumboPot
Nice job gumbopot!
Posted on 5/18/20 at 5:16 pm to BarnHater
quote:
Simply put, the medicine works and the president has known that since day one.
Posted on 5/18/20 at 5:17 pm to GumboPot
God I hated organic chemistry. That class can eat a dick. Thanks for the flashback.
Posted on 5/18/20 at 5:31 pm to GumboPot
quote:
success stories using HCQ/Az/Z2+
+ actemra if you have markers for cytokine storm
I feel a little retarded for "researching" (my medical knowledge is equivalent to a 7yo cocker spaniel stripper) my own treatment on the internet and through medical professional friends, but I just don't trust the system right now.
With that being said, would this be a good treatment to demand if I end up with the Chinese Virus?
Also, hypothetically speaking, when would be the best time to start this treatment if I have access to all of this stuff? Any preventative uses for this cocktail?
I'm already hyped up on water, vitamins, and Zinc.
Btw, I need 5yo explanations. I'm purposely retarded in this area, so a phlebotomist at the local plasma center can wow me with her brain. I like smart chicks, so I manufactured a bunch of smart chicks by not even knowing the difference between Tylenol and Bayer.
This post was edited on 5/18/20 at 5:38 pm
Posted on 5/18/20 at 5:35 pm to GumboPot
quote:
First hydroxychloroquine is a safer alternative to chloroquine. Structrually they are very similar except hydroxychloroquine has an alcohol group where chloroquine has a methal group (the top right side of each molecule). This makes hydroxychloroquine more water soluble thus allowing a higher rate of metabolism and less bio accumulation.
Yeah this all sounds reasonable but what does Dr Fugazi......errr....Fauci say?
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