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stout
Arizona Fan
Smoking Crack with Hunter Biden
Member since Sep 2006
154930 posts

'Worst version of COVID' will be dominant in U.S. by July

'The worst version' of COVID is spreading. Can we update our vaccines in time?


quote:

For the last 18 months, the original COVID-19 vaccines — first as a two-dose series, then as boosters — have done an extraordinary job shielding us from illness, hospitalization and death. Globally, they saved nearly 20 million lives in 2021 alone. Even today, unvaccinated Americans are twice as likely as vaccinated Americans to test positive for COVID — and six times as likely to die from the disease.

But viruses evolve, and vaccines should too.

That was the big-picture takeaway from a pivotal meeting this week of the U.S. Food and Drug Administration’s expert advisory panel. The question before them was simple: Ahead of an expected winter surge, should vaccine manufacturers tweak their forthcoming booster shots to target Omicron — the ultra-infectious variant that has spent the last seven months surging throughout the world in one form or another — or should they stick with the tried-and-true 2020 recipe?

The panel voted 19-2 on Tuesday in favor of Omicron boosters. The question now, however, is which version of Omicron the next round of shots should target.

For anyone who hasn’t been paying attention, the Omicron strain that triggered last winter’s massive COVID wave (BA.1) is now extinct. In March, it was supplanted by the even more transmissible BA.2 … which was supplanted in May by the even more transmissible BA.2.12.1 … which is now being supplanted by the (you guessed it) even more transmissible BA.4 and BA.5.

Experts say BA.5 is the one to worry about: “The worst version of the virus that we’ve seen,” as Dr. Eric Topol, the founder of Scripps Research Translational Institute, recently put it. Together, the closely related BA.4 and BA.5 now account for the majority of new U.S. COVID cases, according to the latest data from the Centers for Disease Control and Prevention — but BA.5 (36.6%) is spreading a lot faster than BA.4 (15.7%). By early July, it will be the dominant strain in the U.S.

That’s troublesome for several reasons. To our immune system, the distance from BA.1 to heavily mutated BA.4 and BA.5 is “far greater,” Topol writes, than the distance from the original BA.1 virus to previous blockbuster variants such as Alpha and Delta — which makes them harder to recognize and respond to.





beebefootballfan
Hawaii Fan
Member since Mar 2011
16495 posts

Get you some more shots Covid Bros


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561
Oates Mustache
US Space Force Fan
Member since Oct 2011
17342 posts
 Online 

Ok, so now they need to list the hospitalization numbers. Crickets


Cosmo
Houston Astros Fan
glassman's guest house
Member since Oct 2003
112322 posts

The only cure is mail in voting and more abortions


A Menace to Sobriety
Houston Astros Fan
Member since Jun 2018
20670 posts

Just in time for the mid terms.


FredBear
USA Fan
Member since Aug 2017
12210 posts
 Online 

The Branch Covidians just nutted


Demshoes
LSU Fan
Up in here
Member since Aug 2015
8903 posts

Lock it down. Shut everything down preemptively. Mask up. 8 masks.


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331
Oates Mustache
US Space Force Fan
Member since Oct 2011
17342 posts
 Online 

quote:

The only cure is mail in voting and more abortions


They can use the aborted fetus fluid to sign the mail in forms.


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251
NIH
LA-Lafayette Fan
Member since Aug 2008
108304 posts

I’m thankful to be vaccinated and boosted. My wife’s two year old son thanked me on the way to school today for bringing him to get his booster. Had to hide the tears as he climbed out of my Sienna.


fightin tigers
Downtown Prairieville
Member since Mar 2008
66369 posts

Takeaway fron "worst version"

quote:

More breakthrough infections, especially among people who previously had BA.1. Compared to BA.2, BA.2.12.1 is only modestly (1.8-fold) more resistant to antibodies from vaccinated and boosted individuals. But BA.4 and BA.5 are substantially (4.2-fold) more resistant.

More symptoms. BA.4 and BA.5 are also better at replicating in lung cells than BA.2 — a shift that could mean, according to one experimental model, that they’re more “pathogenic” as well (i.e., more likely to make you sick).

More resistance to treatments. At the same time, BA.4 and BA.5 appear to be 20-fold more resistant than BA.2 to Evusheld — an important monoclonal antibody treatment that has been providing preemptive protection for immunocompromised people.


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14
bad93ex
US Navy Fan
Member since Sep 2018
15379 posts
 Online 

More fear porn!!


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153
stout
Arizona Fan
Smoking Crack with Hunter Biden
Member since Sep 2006
154930 posts

quote:

Just in time for the mid terms.



Yup


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101
Dragula
Georgia Fan
Laguna Seca
Member since Jun 2020
2434 posts

Hospital Pulmonologists and Intensivists...





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191
dgnx6
Atlanta Braves Fan
Baton Rouge
Member since Feb 2006
53503 posts
 Online 

Lol imagine getting a vaccine and multiple boosters that don’t even work.



TxWadingFool
Texas A&M Fan
Middle Coast
Member since Sep 2014
3422 posts

Getting over my second bout with rona in 6 months, symptoms were the same both times. Low grade fever for 24 hours, made me miserable for a couple days. General fatigue for about 4 or 5 days with a nagging cough but today is my 6th day and I'm back to 90%. Still vaccine free and plan to stay that way, as someone that has had the flu several years back the rona doesn't have shite on it.


Dragula
Georgia Fan
Laguna Seca
Member since Jun 2020
2434 posts

quote:

Lol imagine getting a vaccine and multiple boosters that don’t even work.




Even worse, imagine being forced to get it or be terminated


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212
A Menace to Sobriety
Houston Astros Fan
Member since Jun 2018
20670 posts

2 weeks to flatten the curve for real this time folks. As long as we're saving lives.


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101
FredBear
USA Fan
Member since Aug 2017
12210 posts
 Online 

quote:

Getting over my second bout with rona in 6 months, symptoms were the same both times. Low grade fever for 24 hours, made me miserable for a couple days. General fatigue for about 4 or 5 days with a nagging cough but today is my 6th day and I'm back to 90%. Still vaccine free and plan to stay that way, as someone that has had the flu several years back the rona doesn't have shite on it.



Yeah, I got it in January and I had a sore throat and was tired for about a week and then was fine, no worse than the regular flu. I'm never getting vaccinated either


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102
OweO
USA Fan
Plaquemine, La
Member since Sep 2009
104685 posts

How much are these companies getting paid for every new vaccine?


ronk
Member since Jan 2015
3838 posts
 Online 

I currently have covid even though I refused to get tested. Wife works as a teacher, 3 year old goes to the same school. Small private school. Multiple kids/teachers tested positive. Son runs a fever, tired, etc. Two days later I get a fever and fatigue. Take Tylenol and fever gone in 5 hours. I’m on day 3 of a mild runny nose. If this is “the worst” then nobody has died of covid in the past. All with covid.


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