re: When will the studies on hydroxychloroquine be complete?

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But one thing they have learned it can and has saved lives.

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Not from formal studies, however.

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Who is calling for having people take it without a doctor’s prescription?

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You and I know that there are people who trust politicians more than scientists. This s a warning to them that bad things can happen to them without the guidance of a doctor.

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It doesn’t attack the virus. What it does is lessen the immune system’s reaction to the virus. It’s the body’s immune system’s overreaction to the virus that kills people.

Here, this should explain it...

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I take the immunosuppressants Cell Cept and Tacrolimus each twice daily. I should be gold, baw.

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Not from formal studies, however.

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Formal studies are underway with all indications being promising.

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You and I know that there are people who trust politicians more than scientists. This s a warning to them that bad things can happen to them without the guidance of a doctor.

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I could be wrong but it was doctors who discovered it appears to help, not politicians. In fact I don’t know of a single politician who has told anyone to go home and start taking hydroxychloroquine or any other medicine. I’ve heard President Trump say he’s hopeful and it looks promising that it could be a gamechanger. Is that what you’re against? The president being hopeful?

ETA: your downvote tells me all I need to know. Just another pathetic progressive with stage 4 TDS. I pity you.

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My primary care doctor sent out an email to his patients this morning that included this:

"The use of hydroxychloroquine and azithromycin for the treatment of Covid19 is talked about almost daily. There are significant cardiac risks involved with this combination. Currently, it is being used in the hospital with appropriate cardiac monitoring only. There is no prophylactic value known at this time."

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This is why people should only use it under the care and direction of a doctor.

LINK

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n this particular series, 1061 patients received HCQ + azithromycin (HCQ+AZ) for a minimum of 3 days. Of note, their population had a slight female predominance (53.6%). They evaluated 3 primary outcome measures: viral clearance, worsening of disease, and death. Approximately 92% of those in this series showed viral clearance within 10 days; those with persistence of virus on PCR had a higher reported viral load. Overall, 4.3% of patients (46 in all) reportedly had poor outcomes – death (0.47%), transfer to ICU (0.94%), or prolonged hospitalization > 10 days (~3%). They reported that poor clinical outcomes were more likely to be seen with older age, initial higher severity, low HCQ concentrations, use of selective beta-blocking agents or ACE-inhibitors. The case series reportedly showed no evidence of cardiac toxicity. While the Raoult study is informative, it is essentially a large case series and lacks a control group to fully discriminate the effects of the drug on this particular population. It will be particularly interesting to see the details of the drug administration (whether it was administered early in the onset of the disease), the patient characteristics, whether there was any dose or duration dependence on clinical outcomes, and the details of the statistical analyses for the reported odds ratios since confidence intervals were not included in the abstract. Since the authors also report that of the 3165 positive COVID19 cases, only 1061 received HCQ+AZ, it would be interesting to compare this population against the other COVID19+ cases that did not receive the combination drug regimen. On the flip side, the French Regional Center of Pharmacovigilance has tracked cases of HCQ toxicity related to administration for COVID19. To date, there have been 54 cases who developed prolongation of QT-intervals, dysrhythmias, and 7 cases of sudden cardiac arrest of which 3 responded to electrical stimulation and 4 died. (LINK Likewise, a small study in Brazil has been suspended due to a signal highlighting increased incidence of cardiac dysrhythmias in patients receiving a higher dose of chloroquine in a non-placebo-controlled study involving 81 hospitalized COVID19 patients. (LINK While these data do not discount the potential benefits of using HCQ with or without AZ early on in the course of COVID19, more controlled data will be helpful in determining if and how best to utilize the drug, in order to avoid potential toxicities.

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Here is the entire story Zappa failed to report on.

I sincerely hope the combo proves to be a good therapy, especially for older adults. Many drugs and therapies are being rushed into trials against this virus that we’ve never seen before.

We have to remember that we’re in the middle of a pandemic and normal scientific checks and balances cannot rule the day. Anyone who is afflicted with the virus should be allowed to try the experimental drug/therapy of his choice.

Doctors, pharmacists and health care workers should have the same freedom to refuse to be involved lest they be liable if their patients suffer injury or death.

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If it becomes a major mitigator it’ll drop drastically as more supply is generated. Remember economies of scale from economics class in college?

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I seriously doubt that happens since Gilead Sciences owns the patent. Maybe after the patent expires.

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Some scientific chick was talking about it on the news a little while ago. I was in the middle of something, so I didn't really pay that much attention, but from what I caught, she seemed to be saying good things about how it was doing.


This is the kind of info that has made the OT my #1 news source.

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It would have been better if he told us if she was hot.

But he gets a downvote for not providing pics.

Steroids worked for me together with some other antibiotics and anti microbials. Start the trials......