re: Study: people return to baseline weight within 1.5 years of stopping GLP-1s

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People with blood pressure issues get high blood pressure when they stop taking statins

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you sure about that? care to explain the exact mechanism of how statins control blood pressure please?

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This is why it’s truly best to embrace a slow weight loss with sustainable lifestyle changes balancing results with satisfaction for adherence. Once a goal weight is achieved, ever so slowly return to maintenance to build a new set point.

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That's really the only chance the average person has. But even then, most won't be able to thread the needle for more than temporary weight loss. I guess the younger you are when you lose weight the more likely you are to be able to reset, just like anything else.

Obesity is a lot more like type 2 diabetes than it is a lifestyle problem, although both are caused by lifestyle problems.

Once the hormones go over the cliff it's possible for some people to reverse the mayhem, just like it's possible for some people to "reverse" type 2 diabetes, but it's just not possible for the majority. There is a significant minority that can lose weight and keep some of it off. A smaller minority that can lose weight and keep most of it off. And a tiny fraction who can lose weight and keep all of it off.

The majority gains it all back.

Obesity sucks. As far as I know there has never been a nation that has successfully significantly reversed the obesity trend. Once it starts in a country—just like an individual—it's pretty much there to stay, with no more than minor fluctuations.

We've got to focus on prevention and stop believing that it's possible to reverse it, because it largely isn't. Not long term, anyway. The diet and "wellness" industry has convinced everyone that it is, but all the data says the opposite.

The message needs to change to avoiding it in the first place.

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I eat whatever I want and don’t get fat. The key is not wanting to eat garbage

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Or having ridiculous metabolism

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but they dont change anything other than making you not as hungry and controlling insulin.

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They are finding they actually do a lot more than that. For context, I’m 6’3” 200 pounds. I’ve always been thin and muscular. I go to the gym every day, lifting and cardio. My problem: Hypertension. Both of my parents have it. Tried everything to get off BP meds BC they make me feel like shite.
My doctor has me micro-dosing a GLP-1 (it’s a tiny dose b/c I cannot afford to lose weight) for HTN. Been a few weeks, and I’m off one BP med. My appetite is exactly the same btw. Cautiously optimistic.

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I don't know about you, but IME people who say, "I eat whatever I want, however much I want, and I don't get fat," actually seem to eat relatively little if you actually observe them.

They just don't want as much as other people.

I have seen the odd person who eats a lot and still doesn't gain weight, and sure, some of them just have a genetically high metabolism.

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I am that person. My dad was the same way until his mid 40's. I'm 43, so I'm expecting that to change for me in the next few years.

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I thought it was assumed this was a life long drug.

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Not for everyone. My situation is kind of different as I didn't even want to take the shot.
But I used it for 6 months to get back into running shape.

Been off it for 2 months now and have lost 8 more lbs because I'm training for 5ks again and lifting 4 days a week.

I can, however, see exactly how it happens. You do get that appetite back within a couple of weeks.
I am hungry all the time now especially with the training.
But I continue to track calories with My Fitness Pal and stay well under 2500cal a day with minimal carbs. While on the shot and not training(i was walking and lifting only) I would stay under 2000 cal a day.

Down 107 lbs now(lost 25 on my own Since 2022, and 80 since July 1, 2025) and will never return anywhere close to that baseline weight. Book mark this and check back in 1.5 years.

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They are finding they actually do a lot more than that. For context, I’m 6’3” 200 pounds. I’ve always been thin and muscular. I go to the gym every day, lifting and cardio. My problem: Hypertension. Both of my parents have it. Tried everything to get off BP meds BC they make me feel like shite.
My doctor has me micro-dosing a GLP-1 (it’s a tiny dose b/c I cannot afford to lose weight) for HTN. Been a few weeks, and I’m off one BP med. My appetite is exactly the same btw. Cautiously optimistic.

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yea they do, they help with plenty of health things, including what you mentioned and also with addiction to alcohol, smoking, gambling etc

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I used one for about a month, I could not stand the way it made me feel so I stopped, I lost 10lbs, but the bigger win was showing I could eat a lot less than I was before the drug. After I quit, I have changed my eating habits and eat a lot less than before.

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This is where it helps to have a conversation with a patient regarding the why these drugs work for weight loss. It is nothing magic, but the immutable fact is that they effect a change in energy balance. I think once people see that you can't get around the energy taken end vs. energy expended equation, it shows that fewer calories really do work.

youre telling me people who are too lazy to develop good eating habits and exercise get fat again after stopping pharmaceutical intervention. Wow! who would have thought?

Who would have thunk it?? You los weight then go back to eating like shite and you gain weight…. Wow