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re: New diabetes medications prove the OT wrong, obesity is not always a choice

Posted on 9/7/23 at 3:35 pm to
Posted by ole man
Baton Rouge
Member since Nov 2007
15043 posts
Posted on 9/7/23 at 3:35 pm to
Good numbers
Posted by caro81
Member since Jul 2017
5672 posts
Posted on 9/7/23 at 4:01 pm to
quote:

Not to say you can’t abandon those behaviors once you get off of the meds


the people getting on these medications have already shown they are not predisposed to having good monitoring and decision making when it comes to food. i would be willing to make a sizeable monetary bet that more people getting off this drug will gain weight back than those that retain weight loss numbers during its use.
Posted by WeeWee
Member since Aug 2012
42901 posts
Posted on 9/7/23 at 4:01 pm to
quote:

not true...i sent you an article with over a dozen linked studies showing this is false


Your article is wrong.

quote:

CR is defined as a sustained reduction in energy intake from pre-intervention energy requirements while maintaining sufficient nutrient supply to achieve weight stability. Initially CR induces weight loss and over time energy expenditure (EE) declines until it eventually matches energy intake and the new lower body weight plateaus.
LINK
This post was edited on 9/7/23 at 4:06 pm
Posted by Pikes Peak Tiger
Colorado Springs
Member since Jun 2023
6738 posts
Posted on 9/7/23 at 4:08 pm to
quote:

2. It is obviously not as simple eating and exercising properly or else it would be a lot easier to combat obesity.


It actually is. It’s the psychological hurdle that most can’t overcome.

But as several people noted in this thread: if you burn more calories than you take it, it is not possible to be fat or gain weight.
Posted by DeoreDX
Member since Oct 2010
4156 posts
Posted on 9/7/23 at 4:12 pm to
quote:

I agree. Just bc someone’s says they’ve been going to the gym doesn’t mean they’re putting in the effort needed to see results.


So I'm no Dr or Expert. I do train for cycling using the polarized Zone 2 training methods and I'm familiar with Dr Attia because of this. I'm familiar with the different ways our body makes energy. I'm a very fit 160lbs, but I couldn't stand up with an extra 100lbs and walk to the mainbox and back without going anaerobic because of the effort required to move the extra 100lbs. Just my caveman theory is through bad eating habits and lack of exercise people probably reach a point where they can't move from point A to point B without instantly moving into the anaerobic energy production phase. Once you hit that point it's very difficult to train in the aerobic fat burning zone 2 range. Your body is almost always using carbs for energy. Your fat burning energy pathways soon begin shrink so not matter what you do you are almost never burning fat. Your body needs to carbs for energy as it doesn't have the mitochondria to convert enough fat to keep your body operating so the brain is constantly telling you that you're hungry. Probably that same intense hunger I feel after riding a bike for 4 hours as all my muscle glycogen is depleted.
Posted by Pikes Peak Tiger
Colorado Springs
Member since Jun 2023
6738 posts
Posted on 9/7/23 at 4:16 pm to
quote:

Biology is not physics


Yes it is. At its core level, every natural science is based on physics.
Posted by WeeWee
Member since Aug 2012
42901 posts
Posted on 9/7/23 at 4:17 pm to
quote:

lsu777


You are the one who is acting emotionally. You are the one who doesn’t know what he is talking about. If metabolism didn’t lower to match caloric intake (aka metabolic adaptation) why does weight loss with caloric restriction diets plateau?
Posted by GhostofLesticleMiles
High Plains Drifter
Member since Sep 2019
1053 posts
Posted on 9/7/23 at 4:50 pm to


Trip 7s, your “expertise” has been challenged! Be sure to let him know you are the man on the H&F board.
Posted by WeeWee
Member since Aug 2012
42901 posts
Posted on 9/7/23 at 5:01 pm to
quote:

But as several people noted in this thread: if you burn more calories than you take it, it is not possible to be fat or gain weight.



That is a gross oversimplification of the issue. The issue is the metabolic adaption that reduces caloric expenditure to match caloric intake. That is why weight loss with caloric restriction diets plateaus.
Posted by WeeWee
Member since Aug 2012
42901 posts
Posted on 9/7/23 at 5:20 pm to
quote:

not a very smart one, prolly a GP



Who the f**k do you think deals with obese patients on a daily basis? GPs.

quote:

no it doesnt precent any metabolic adaptation.


Yes it does. Read the study.

quote:

the most significant finding was upregulation of PrLH in the AP following liraglutide or semaglutide administration, which translated into upregulation of PrRP at the protein level (Figure 8). We established that this is likely a consequence of GLP-1RA treatment, rather than a general change associated with weight loss, because it was not evident with other agents (amylin) yielding similar weight loss and did not occur in the weight-matched group. PrRP delivery to the NTS at the level of the AP decreases BW, food intake, and meal size in rats (58). This suggests an inducible system of PrRP production triggered by GLP-1RAs. Given that all PrRP-positive neurons in the AP also expressed GLP-1Rs, it is conceivable that PrRP production is driven through direct activation of the GLP-1Rs in this nucleus. In the NTS, PrLH mRNA expression was downregulated exclusively by weight loss caused by food restriction, as shown previously (59, 60).

PrRP is putatively involved in neuroendocrine function, including energy homeostasis, stress response, cardiovascular regulation, and circadian function (62), and it has been reported to lower BW in rodents, potentially through regulation of food intake and EE (62). Liraglutide reduces food intake (although dose independently) in Otsuka Long-Evans Tokushima Fatty rats harboring a natural mutation in the PrRP receptor (63). Furthermore, we have previously shown that liraglutide can still reduce BW after AP ablation (8). Based on these data and our observations, we hypothesize that PrRP in the hindbrain could be one of several mechanisms involved in the BW-lowering effects of GLP-1RAs, although it is not strictly required.
LINK

The PrLH mRNA and PrRP expression wer upregulated in the group that received GLP1 agonists. PrLH mRNA and PrRP expression were downregulated in the the group that did not receive GLP1 agonists. The group that did not receive GLP1 agonists had a reduction in metabolism. The group that did receive GLP1 agonists did not have a reduction in metabolism. So yes it does appear that semaglutide does indeed prevent or lessen metabolic adaptation.

quote:

first off starvation mode and metabolic damage due to caloric deficit has been debunked completely. read the studies in this article and educate yourself please LINK


quote:

While your metabolism does decrease slightly while dieting,
Your OWN LINK

Your source debates how much of degree metabolism adaptation happens but it does acknowledges metabolic adaptation. Maybe you need to educate yourself on how to read or educate yourself on the definition of debunking.

Also lsu777, I saw in another post where you basically say that the medical industry is a scam and doctors do not know what they are talking about when your link is a personal trainer's whose is trying to sell his weight loss plan and supplements to the reader. The irony and stupidity of your posts is beyond quantifying.
This post was edited on 9/7/23 at 5:41 pm
Posted by offshoretrash
Farmerville, La
Member since Aug 2008
10539 posts
Posted on 9/7/23 at 5:31 pm to
I've got a couple of friends who are overweight and something I notice about all of them is that food is like a drug to them. They try everything to lose weight but can't do it. One of them had stomach surgery to lose weight, and he'd get mad cause he couldn't eat as much.

I'm a type 2 diabetic, I was probably 20lbs overweight. The medicine they gave me at first killed my appetite, and I lost 15lbs real quick. I'm on a different medicine now, but I haven't gained any back, but I don't eat or drink anything with sugar in it anymore.
Posted by WeeWee
Member since Aug 2012
42901 posts
Posted on 9/7/23 at 5:43 pm to
quote:

I've got a couple of friends who are overweight and something I notice about all of them is that food is like a drug to them. They try everything to lose weight but can't do it. One of them had stomach surgery to lose weight, and he'd get mad cause he couldn't eat as much.


Did he expect to still be able to eat as much after having a surgery in which commonly called stomach stapling?
Posted by offshoretrash
Farmerville, La
Member since Aug 2008
10539 posts
Posted on 9/7/23 at 6:42 pm to
No but it would make him so mad when I got something to eat and he couldn't eat anything. He's back up to around 300lbs again.
Posted by RoyalWe
Prairieville, LA
Member since Mar 2018
3777 posts
Posted on 9/7/23 at 6:45 pm to
quote:

Whatever helps yall fat pieces of shite sleep at night.
I laughed.
Posted by lsu777
Lake Charles
Member since Jan 2004
35006 posts
Posted on 9/7/23 at 6:48 pm to
quote:

Your article is wrong.


Dude you can’t be this dumb… do you not understand the difference between bmr and tdee? Tdee decreases due to lower energy levels. But bmr doesn’t drop, even your link states that.

There are 8 billion studies showing this. The article isn’t wrong and I didn’t link the article for the article I listed it for the linked studies in it. Which are correct and show exactly what I said

Again tdee is not metabolism, bmr is. And bmr does not go down.

Again you are wrong as usual good doc. I told you, you are out of your depths here. I wouldn’t challenge you on things you would obviously know more about….you should maybe do the same.
Posted by lsu777
Lake Charles
Member since Jan 2004
35006 posts
Posted on 9/7/23 at 6:50 pm to
quote:

You are the one who is acting emotionally. You are the one who doesn’t know what he is talking about. If metabolism didn’t lower to match caloric intake (aka metabolic adaptation) why does weight loss with caloric restriction diets plateau?


Because neat drops dumbass.

Again bmr will drop some due to needing less energy for the new weight but tdee doesn’t drop

Again since you are so smart tell me what mechanism glp affects metabolism!! Please

Newsflash it doesnt
Posted by lsu777
Lake Charles
Member since Jan 2004
35006 posts
Posted on 9/7/23 at 7:02 pm to
Stop saying metabolic adaptation!!

Sure you get a small decrease due to the weight loss around month 3 and 6 but they are not significant in terms of bmr. Read this

LINK
Posted by lsu777
Lake Charles
Member since Jan 2004
35006 posts
Posted on 9/7/23 at 7:41 pm to
quote:

our source debates how much of degree metabolism adaptation happens but it does acknowledges metabolic adaptation. Maybe you need to educate yourself on how to read or educate yourself on the definition of debunking. Also lsu777, I saw in another post where you basically say that the medical industry is a scam and doctors do not know what they are talking about when your link is a personal trainer's whose is trying to sell his weight loss plan and supplements to the reader. The irony and stupidity of your posts is beyond quantifying.


A) let’s get this straight, I’m not a personal trainer, I have multiple certifications it I don’t sell shite. I work as an engineer for a living but I do help oversee people though but for free. I told you from the start that dont pay attention to the article i linked, i said look at the linked studies at the bottom. I could care less about the actual article or what mike matthews says, i was more linking it because it had a very good list of citations of multiple studies that actually addressed the subject.

B) as far as the study, the part you linked was on rats. we know that those effects only translate over about 50% of the time at most to humans. second it says they hypothesized...meaning they are guessing, educated guess, but guessing none the less. again...you havent shown any proof.

C) of course the metabolism slows some, you weigh less but it’s not much as far as bmr. Neat falls though because energy levels go down and that makes up the biggest difference. Sure there are some adaptations but the amount that BMR drops once weight is equated is so low it falls into the non meaningful category. but yea if i weigh 400 and a 3500 calories diet puts me at a 500 calories surplus....of course after i lose 100lbs i will not be able to continue to eat 3500 calories and lose weight.

but there are also things called diet breaks and reverse diets that help compliance overall for the diet and should be done every 3-4 months to help with leptin levels.

D) glp1 has no mechanism to increase metabolism so how would it prevent a stall? Gene expression doesn’t change that

Oh and I said most GPs don’t know shite about exercise and diet. I didn’t put down doctors as a whole and sure as shite didnt say the medical industry doesnt know what its doing. I respect the shite out of good doctors. in fact even though i been giving you shite on this....the simple fact you are even looking into these kinds of things, are willing to learn and know how to actually read studies means you are prolly in top 5% of GPs and i would have no problem seeing you myself.

I think the world of Jose as a doctor because he does the same thing.

I sure as hell don't know everything, but I'm pretty good at finding and understanding research papers, causation vs correlation, root cause etc. I also love to learn and am more than happy to admit when I'm wrong.

I also 100% support you using these medicines on people. I just don't think that obesity is some kind of boogie man disease that isn't a choice. Do life circumstances make it hard sometimes? absolutely, same with learned behaviors but still a choice.

I grew up in a household just like so many here have talked about. non exercise family, always clean your plate etc...when I quit lifting and got up to 245 lbs. I made a decision to lose the weight. it was a decision and I made it because that shite is miserable.

obesity is a choice or those in concentration camps or other things were they are exposed to starvation would lose so much weight.

You as a doctor need to come to the realization that despite what they say, not every obese person wants to lose the weight and saying they are being complainant with food and exercise logging doesn't mean they actually are. hell go ask anyone how much a serving of Peanut butter is and 99% will be wrong.

The above though is why these medicines are so great. they force the change in behavior if the person is willing to take it. Its either change or be miserable, period. That's why they will change the way we treat obesity.
This post was edited on 9/8/23 at 8:33 am
Posted by Penrod
Member since Jan 2011
47589 posts
Posted on 9/7/23 at 8:02 pm to
“No one ever gained weight in a lifeboat.”
…my dad
Posted by Penrod
Member since Jan 2011
47589 posts
Posted on 9/7/23 at 8:07 pm to
Every fat person I’ve ever known well overeats. My poor mom always wanted to lose weight. She tried and tried. But she couldn’t diet for more than four weeks. Eventually she would start overeating again.

My mom was a 5’ 4” tall woman. I am a 6’ 2” tall man. And if I ate as much as my mom used to I’d be fat. This is true of at least the other half dozen or more fat people I’ve lived wit or worked closely with for long enough to get a good view of their diet and exercise.
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