re: Scientific discussion on supplements

Yea I have been knowing about Berberine in the form of yellow gold and pslin for about a decade now but the new info on how effective it is and the other health benefits were new to me.

Knew it could help with nutrition partitioning, but not to what extent.

Yea, prolly later this week

I was watching a Joe Rogan podcast the other day with Dr. Rhonda Patrick. She’s amazingly intelligent. She talked about a lot of things, but one thing that stood out was this FOX03–I think it’s a gene. It’s supposed to help suppress or even reverse aging by keeping DNA or RNA intact or something like that(I am clearly not a doctor). She said that getting in a sauna a couple times a week has been shown to activate this gene.

Somehow, I came across a link to Alive By Health’s website. They sell NMN and NAD+ supplements and have some studies linked on their site. Again, appears to be more anti-aging stuff. Never heard of any of these before Monday and am wondering what any of y’all may be able to tell me.

So today I wanted to discuss some items to help those with kidney issues and even reverse kidney damage.

The first one is grape see extract (not grape fruit)


This study shows that grape seed extract can and will reverse renal failure. Takes time, but so did causing the failure. It is dose dependent also. Dosage should be 400-800mg twice daily.

Other benefits- meta-analysis showed it can slightly lower systolic BP. Also has proven to improve blood flow in multiple studies.




Next compound is Astragalus. It is the main compound to rely on if kidney problems arise LINK LINK LINK

Astragalus is dose dependent and has been shown to regenerate kidney function. Reports of bodybuilders bringing themselves back from the brink of dialysis by megadosing close to 9g both morning and night. Basic dosage for those just looking to maintain function is 2g twice daily. Most with issues would do really well on 4g twice daily.



The third compound in our kidney repair Trinity is pycnogenol or pine bark extract. LINK LINK. Simply using 100mg twice daily is all you need.

The above serve as three prong attack to get the kidneys in working order. It usually takes 6 months or so to regain close to full function using the above, assuming one has corrected the action of that was causing the issue in the first place if it was an outside compound.

This afternoon I will post the supplements I believe and have shown the ability to really really help cholesterol and what the protocol is. Tomorrow I will do one on cardiomyopathy which k believe is a huge issue that people don't focus enough on.

I'm 3-4 weeks in on berberine. I'm not really being scientific about it, but it does seem to be helping in body recomposition goals.

I'm still hovering around 200 at 6'3. I've set or tied PR's on squat/dead for 6 weeks in a row. Abs seem to be sharpening up. That's basically the effect I'm looking for. I just haven't done a ton of scientificish measurements to have a solid foundation beyond my subjective thoughts.

Since we are in South LA and many suffer from tinnitus, I figured it would be a good time to talk about the effects of Dietary Taurine on Tinnitus.

This study shows that high taurine doses significantly attenuated tinnitus, which returned to near pre-treatment levels following washout.

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Some frequency aspects of the tinnitus (e.g., 16 kHz, Fig. 2B vs 2F) were more effectively attenuated by taurine than others (e.g., 20 kHz, Fig. 2C vs 2G). Reasons for this therapeutic profile were not clear, although the traumatizing stimulus had its maximum level, and maximum long-term threshold effect at 16 kHz. If, as hypothesized, taurine stabilizes auditory processing, its therapeutic impact may have been greatest in tonotopic areas were the impact of acoustic trauma was also greatest.

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Three main effects were obtained with supplemental dietary taurine: (1) A significant, and reversible, tinnitus therapeutic effect was evident at the high dose level (4 mg/ml, or 294 mg/kg/da), but not the low dose level (1 mg/ml, or 67 mg/kg/da). (2) At the low dose, taurine may have exacerbated high-frequency components of the tinnitus. (3) Auditory discrimination performance was enhanced in normal-hearing rats in a dose-dependent manner.

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So if you want to hear better, start supplementing with Taurine. I suggest 2g split to start. It is dose dependent, but do not exceed 4g or so.

Taurine has other benefits including cramping, increased blood flow along with being very good for the heart

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Taurine

Taurine (L-taurine) is a conditionally essential amino acid found abundantly in the body — particularly in heart tissues where it helps maintain a regular heartbeat.[13] Under healthy conditions, our bodies can produce taurine from the amino acids methionine and cysteine and from vitamin B6.

In patients with heart failure, short-term taurine supplementation (~2 weeks) yielded improvements in cardiovascular function surrounding a bout of exercise.[14][15][16] Studies have also suggested that taurine may have some beneficial effects on blood pressure in those with pre-hypertension or hypertension.

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So if you have hearing problems, get on Taurine. It's extremely good for you and it will restore hearing over time.

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NA-R-ALA

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I tried a bit of this and the stomach side effects were rough. Berberine gives me a little stomach upset, but it's tolerable. The NA wasn't tolerable, so I stuck with Berberine only.

I already have IBS, so I'm careful because it's easy to set my s**t off, literally.

Of course, been following every word he says for years now then researching my self. Same with Scott.

what do you think of this intra EAA

Bilj, 777 ... what are yalls thoughts on D-Aspartic Acid?