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On Mounjaro for two months, my take (long read)

Posted on 4/4/24 at 7:42 pm
Posted by theantiquetiger
Paid Premium Member Plus
Member since Feb 2005
19187 posts
Posted on 4/4/24 at 7:42 pm
I got my first shot Feb 1st (2.5mg). I was on 5mg for the next eight shots (was supposed to go to 7.5mg after four shots of 5mg, but mix up on prescription kept me on 5mg another four weeks). I took my first 7.5mg last night.
My results:
-Down from 265lbs to 227lbs (first 25lbs fell off in 5 weeks)
-Blood pressure down from 150/90 to 120/75
-Stopped snoring (wife loves it) and sleeping better
-Blood sugar sub-100, even without fasting the night before
-Size 42 waist to a 36 waist

I did radically change my diet (you have to on this medication). I’m probably eating 1500 calories a day (never really added them up). Another big thing is I cut out soft drinks. Granted, all I use to drink was Diet Dr Pepper, but was drinking way too much. Carbonated drinks make me feel like shite now (full). I’m drinking about 100 fl oz of water a day now, nothing else.

I cannot wait to see my A1C in 4 weeks. My last A1C was 6.4 in January.

The only side effect I’ve had was a huge headache every time I went up on dose, and mild headache after each dose.

I did start working out again, but nothing major, mostly 30-mins on elliptical and just some light weights, 2-3x a week.

MrsAntiqueTiger has been on since October, paying out of pocket ($$$$). She’s down a lot of weight, won’t say starting weight, but she’s closing in on 140 lbs (her target weight).

Here’s an example of what we eat now. Last week we went to Lit Pizza. We split one pizza and did no finish it (ate 2 slices each). Tonight she wanted fajitas. We got a fajita for one person from Las Palmas. We each ate one fajita wrap. The box comes with four. We couldn’t even eat the beans and rice.

I eat about five-six times a day now, basically all snacks. Oats and boiled egg for breakfast, a fruit around 9am, nuts, cheese, & fruit for lunch, yogurt for snack, and a light dinner.

It has changed my life. Question is, what happens when I get off of it? I am still going to the 10mg dose next month, then re-visiting my doctor.
My target weight is sub-200, I’m 6’ tall.
This post was edited on 4/4/24 at 7:53 pm
Posted by Uncle JackD
Member since Nov 2007
58627 posts
Posted on 4/4/24 at 7:57 pm to
Solid work. Keep it up.

quote:

dinner. It has changed my life. Question is, what happens when I get off of it? I am still going to the 10mg dose next month, then re-visiting my doctor.
Same. It’s completely changed my life. As for getting off… don’t rush it. Get your diet, workout routine, and lifestyle completely adjusted and in concrete. After that, you can slowly begin to wean down if you choose. Or stay on it indefinitely if you choose. There no downside to this if done properly. My one piece of advice is to start lifting now. I waited almost 6 months before lifting and definitely lost muscle mass. I’m lifting heavy 5-6x a week now and catching up, but if I could turn back time, I would’ve started way sooner.

Anyways, keep it up. It’s an amazing drug.
Posted by theantiquetiger
Paid Premium Member Plus
Member since Feb 2005
19187 posts
Posted on 4/4/24 at 8:11 pm to
quote:

My one piece of advice is to start lifting now.


I’m nearly 56 years old, I’m not about to start working out heavy with weights again. I’ve had too many surgeries in the last 10 years (bicep, shoulder, hernia). I just do light weight (dumbbell bench press 30# each for example). Just trying to keep flexibility and some strength. I don’t go to muscle fatigue or anything.
Posted by jose
Houma
Member since Feb 2009
28567 posts
Posted on 4/4/24 at 8:12 pm to
quote:

It has changed my life. Question is, what happens when I get off of it? I am still going to the 10mg dose next month, then re-visiting my doctor. My target weight is sub-200, I’m 6’ tall.


Are you diabetic? You mentioned it was 6.4 last time it was checked, but are you diabetic? 6.5 is the cutoff so just curious.

Sounds like you’ve made some strides and hope you can keep it off!
Posted by theantiquetiger
Paid Premium Member Plus
Member since Feb 2005
19187 posts
Posted on 4/4/24 at 8:20 pm to
quote:

Are you diabetic? You mentioned it was 6.4 last time it was checked, but are you diabetic? 6.5 is the cutoff so just curious.


Yes, I’m diabetic. The highest my A1C’s have ever been was 7.8 (when I was first diagnosed). It’s been in the 6’s ever since, getting as low as 6.1 last year.
My doctor says they should be in the 5’s by next month.
Posted by Uncle JackD
Member since Nov 2007
58627 posts
Posted on 4/4/24 at 8:20 pm to
quote:

I’m nearly 56 years old, I’m not about to start working out heavy with weights again. I’ve had too many surgeries in the last 10 years (bicep, shoulder, hernia
I never said to deadlift 450# Any resistance training will help. 56 is fricking young. I see 70 yr olds in the gym.

I’ve been on these meds a while and just trying to help you. The more lean mass you add, the better your odds of not rebounding to that CPAP.
This post was edited on 4/4/24 at 8:22 pm
Posted by TideSaint
Hill Country
Member since Sep 2008
75849 posts
Posted on 4/4/24 at 8:23 pm to
Have you experienced a lot of muscle loss?

My brother is fairly large and I've recommended he try Mounjaro or Ozempic and his rebuttal is he doesn't want to lose his muscle mass, only fat.

I think he's scared of not eating whatever he wants but his hesitation may be valid.

ETA: Just a gee whiz question, at what stage of obesity are doctors prescribing this stuff? 20 pounds? 50? 100?
This post was edited on 4/4/24 at 8:26 pm
Posted by BeachDude022
Premium Elite Platinum TD Member
Member since Dec 2006
34803 posts
Posted on 4/4/24 at 8:23 pm to
quote:

Question is, what happens when I get off of it? I am still going to the 10mg dose next month, then re-visiting my doctor.


So I’m part owner in a compounding pharmacy that does mainly Semaglutide (Ozempic) and Tirzepatide (Monjauro). Once you’re off you need to either continue a healthy diet and workout plan or just stay on the meds because you will gain some back. It sucks, but it is what it is
Posted by theantiquetiger
Paid Premium Member Plus
Member since Feb 2005
19187 posts
Posted on 4/4/24 at 8:37 pm to
quote:

I never said to deadlift 450# Any resistance training will help. 56 is fricking young. I see 70 yr olds in the gym.


Like I said, I do lift, but not like I use to in my 30’s.

Chest/tri routine:
30-35# dumbbell bench
25# dumbbell inclined
#30 machine butterflies
#25 cable push downs

My biggest thing is I completely ripped my bicep away from my forearm a few years ago. I lost a lot of strength in it. I basically started over. As an operator, there’s things I cannot do anymore (open long winded steam valves, for example)

I will eventually increase the weight. Right now, I can do 5 sets of 15 reps on my dumbbell bench press. I could easily increase that to 40-50 lbs.
This post was edited on 4/4/24 at 8:56 pm
Posted by theantiquetiger
Paid Premium Member Plus
Member since Feb 2005
19187 posts
Posted on 4/4/24 at 8:42 pm to
quote:

Have you experienced a lot of muscle loss?

quote:

Just a gee whiz question, at what stage of obesity are doctors prescribing this stuff? 20 pounds? 50? 100?


I didn’t really have huge muscles to begin with, my arms and legs were pretty thin, considering I weighed 260+ lbs.

As far as the prescriptions go, I understand insurances are starting to deny it for non-diabetics, because so many people are wanting on it.
I pay $22 a month for 4 shots. My wife paid $120 a shot because insurance wouldn’t cover it.
Posted by ronricks
Member since Mar 2021
6411 posts
Posted on 4/5/24 at 4:00 am to
You could have done all this with diet and exercise. It would have required some effort though. Long term I don’t think this will end well for a lot of folks (not everyone) but there are disturbing trends and reports from people using this for weight loss.
Posted by Mo Jeaux
Member since Aug 2008
58560 posts
Posted on 4/5/24 at 4:22 am to
quote:

My target weight is sub-200, I’m 6’ tall.


175 lbs and 199 lbs are both "sub-200". What is your actual goal?
Posted by pwejr88
Red Stick
Member since Apr 2007
36163 posts
Posted on 4/5/24 at 6:22 am to
What about people that don’t have the drive or motivation for diet and exercise? I would assume a weight loss medication is better than continued obesity. Hopefully the medication can spark new dedication to a healthy lifestyle where the brain couldn’t.
Posted by Uncle JackD
Member since Nov 2007
58627 posts
Posted on 4/5/24 at 6:30 am to
quote:

What about people that don’t have the drive or motivation for diet and exercise? I would assume a weight loss medication is better than continued obesity
absolutely better but if no habits are changed, the weight will come right back as soon as meds are stopped.


quote:

Hopefully the medication can spark new dedication to a healthy lifestyle where the brain couldn’t.
TIRZ + TRT jump started my brain to get its shite together. I’m 40 and For the first time in my life, I look forward and enjoy the gym. I never understood those guys, now I do.
Posted by Grillades
Member since Nov 2009
551 posts
Posted on 4/5/24 at 7:31 am to
The brain? How about the human will? We don't need to live involuntarily. There is an alternative. Just sayin'...
Posted by ronricks
Member since Mar 2021
6411 posts
Posted on 4/5/24 at 8:10 am to
quote:

What about people that don’t have the drive or motivation for diet and exercise?

They will simply revert back to being obese slobs when the monjaro runs out or they stop using it.
quote:

I would assume a weight loss medication is better than continued obesity.

Anything is better than obesity but you can get there without using drugs prescribed/intended for other issues.
quote:

Hopefully the medication can spark new dedication to a healthy lifestyle where the brain couldn’t.


I don't think taking these drugs is sustainable long term we are already seeing perplexing side effects and issues from some (not all) users some that are permanent that are not good.
Posted by lsu777
Lake Charles
Member since Jan 2004
30978 posts
Posted on 4/5/24 at 8:27 am to
quote:

I don't think taking these drugs is sustainable long term we are already seeing perplexing side effects and issues from some (not all) users some that are permanent that are not good.


why are you making stuff up or talking about the 0.01%?

quote:

Anything is better than obesity but you can get there without using drugs prescribed/intended for other issues.


you can but one thing i have learned over the years is, everyone is not you nor I. many hate exercise or have negative thoughts about it for different reasons. Also many have what is referred to as food noise

one thing i have noticed, guys and females that tend to be more emotional tend to have problems sticking to the any time of regiment and staying discplined.

quote:

They will simply revert back to being obese slobs when the monjaro runs out or they stop using it.


most people should slowly go down to prolly 1/2 the lowest dose and stay on that

it has a ton of health benefits and the side effects like the gastro issues effect a very very small portion of users. we have a decade+ of data from those that have been on that are diabetic and we have almost 3+ decades of studying glp-1 and its effects


as far as the question on muscle loss

1) glp-1 is anticatabolic in a vacuum
2) muscle loss happens anytime someone is not resistance training and is in a steep deficit
3) the medicine tends to go to people that do not know how to count calories and macros. Its very very very very important that one hit minimum of 1g protein per lbs of lean muscle on this and thats a minimum. also extremely important to lift progressively over time.

there are studies showing that with lifestyle interventions...i.e. counting macros, prioritizing protein and progressive resistance training that muscle loss is less than those doing the same without the
medicine

and yall should stop fear-mongering, shite is ridiculous. of course some people are going to get side effects. happens with any medicine. Some of the things people say shows a complete lack of understanding of how the drugs work.



and yes it can be used by bodybuilders in a cut. main thing is to use minimum effective dosing, usually much smaller than what is prescribed. the other thing is, its best used in conjunction with peptides so you maintain skin elasticity mainly ghrh(tesamorlin then cjc1295 no dac), ghrp(hex then ipamorelin), bpc, and GHK-Cu.

OP: why are you in such a hurry to raise the dose if you are getting results with the dose you are on?
Posted by ronricks
Member since Mar 2021
6411 posts
Posted on 4/5/24 at 8:44 am to
quote:

why are you making stuff up or talking about the 0.01%?



Not making anything up. I said my part and stick by everything I posted.
Posted by lsu777
Lake Charles
Member since Jan 2004
30978 posts
Posted on 4/5/24 at 8:55 am to
based on what? and what percentage is getting these "weird" side effects
Posted by ronricks
Member since Mar 2021
6411 posts
Posted on 4/5/24 at 9:46 am to
quote:

based on what?


There's currently lawsuits against makers of Ozempic and Mounjaro for a variety of things for one.

I'd say things like severe gastroparesis and cyclic vomiting syndrome are weird wouldn't you? I'm not talking about the typical nausea, vomiting, diarrhea that is common warnings with any drug. Just because the human body produces GLP-1 naturally doesn't mean people should be recreational using these drugs anymore than someone who recreational uses testosterone or hGH just because the body produces it naturally. I certainly wouldn't use these without the supervision of a doctor. You can say these cases are 'rare' but these drugs are becoming more and more popular for weight loss so what happens in the future? I guess time will tell?
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