re: Marijuana research for Alzheimer's cure stymied.

That's your antiscience religious nutjob right wing at work

My mom died 2 years ago at 61 with early onset. I don't wish it upon anyone. Prayers to you and your family. As a staunch conservative the drug war really pisses me off. It's all about the $$$ from Federal money being spent on the drug war machine to the asset forfeiture being done all over the U.S.
There are counties in TX that keep millions of dollars in their forfeiture accounts year round.

I don't think marijuana will cure alzheimers by itself, but I think it will be a huge help. That being said, make it legal already! There are so many proven medical uses for it!

quote:

---

Big Scrub TX

---

Thanks for the link on the book. I'll follow up.

quote:

---

So there must be approved strains. What's the problem?

---

If you read the article, you'd understand that that's the Catch-22. There are none.

quote:

---

I like Jeff Sessions. I really do, and I don't wish him ill-will. Really. But, everyone has to go sometime, so when it's his turn, hopefully he won't know he's dying because his brain will be so ravaged by the very disease that his actions today prevented from being researched and possibly cured.

---

Well said. I don't like the bastard, though. He's either incompetent or paid-for.

Also check out the work of Dr Dale Bredesen (Buck Institute)

quote:

---

Dale Bredesen, MD, Professor
Mechanisms of Alzheimer’s disease and potential therapeutics
Dr. Bredesen is internationally recognized as an expert in the mechanisms of neurodegenerative diseases such as Alzheimer’s disease. He graduated from Caltech, then earned his MD from Duke University Medical Center in Durham, NC. He served as Chief Resident in Neurology at the University of California, San Francisco (UCSF) before joining Nobel laureate Stanley Prusiner’s laboratory at UCSF as an NIH Postdoctoral Fellow. He held faculty positions at UCSF, UCLA and the University of California, San Diego. Dr. Bredesen directed the Program on Aging at the Burnham Institute before coming to the Buck Institute in 1998 as its founding President and CEO.

Dr. Bredesen appears on KQED's Forum program on November 25, 2014 and on KGO-TV on November7.

The uniform failure of recent drug trials in Alzheimer’s disease has highlighted the critical need for a more accurate understanding of the fundamental nature of Alzheimer’s disease. Dr. Bredesen’s research has led to new insight that explains the erosion of memory seen in Alzheimer’s disease, and has opened the door to a new therapeutic approach. He has found evidence that Alzheimer’s disease stems from an imbalance in nerve cell signaling: in the normal brain, specific signals foster nerve connections and memory making, while balancing signals support memory breaking, allowing irrelevant information to be forgotten. But in Alzheimer’s disease, the balance of these opposing signals is disturbed, nerve connections are suppressed, and memories are lost. This model is contrary to popular dogma that Alzheimer’s is a disease of toxicity, caused by the accumulation of sticky plaques in the brain. Bredesen believes the amyloid beta peptide, the source of the plaques, has a normal function in the brain -- promoting signals that allow some of the nerve connections to lapse. Thus the increase in the peptide that occurs in Alzheimer’s disease shifts the memory-making vs. memory-breaking balance in favor of memory loss. This work has led to the identification of several new therapeutic candidates that are currently in pre-clinical trials.

Dr. Bredesen’s novel insights into the fundamental nature of Alzheimer’s disease recently attracted an investment of $3.5 million toward a $10 million goal for initial clinical trials of these new therapeutics. This generous support came from the private venture capitalist Douglas Rosenberg, who is helping to fund the Alzheimer’s Drug Discovery Network, centered at the Buck Institute. The unit is screening drug candidates to find those that can preserve a healthy balance in the signaling pathways that support memory. Dr. Bredesen’s work on nerve cell signaling is also the focus of a collaboration between the Buck Institute and BioMarin Pharmaceuticals, Inc., which is seeking treatments for a rare form of Alzheimer’s disease, early onset Familial Alzheimer’s Disease (eFAD), which may develop in people as young as 30 years of age.

---

TD thread


Prior post from that thread:

quote:

---

"The magnitude of improvement in these 10 patients is unprecedented, providing additional objective evidence that this programmatic approach to cognitive decline is hhighly effective," Dr. Dale Bredesen, a professor at the Buck Institute and the University of California Los Angeles, said in a news release.

---

Podcast

quote:

---

EPISODE 12: DALE BREDESEN DISCUSSES THE METABOLIC FACTORS UNDERLYING ALZHEIMER’S DISEASE

---

LINK

Low carb, ketogenic diet with fasting intervals and MCT oil....
Optimize Vit D, sleep, gut health...

quote:

---

GI health Repair if needed; prebiotics and probiotics Avoid inflammation, autoimmunity

Reduction of Aß Curcumin, Ashwagandha [43-45]

Cognitive enhancement Bacopa monniera, MgT [46, 47]

25OH-D3 = 50-100ng/ml Vitamins D3, K2 [48]

Increase NGF H. erinaceus or ALCAR [49, 50]

Provide synaptic structural components Citicoline, DHA [51].

Optimize antioxidants Mixed tocopherols and tocotrienols, Se, blueberries, NAC, ascorbate, a-lipoic acid [52]

Optimize Zn:fCu ratio Depends on values obtained [53]

Ensure nocturnal oxygenation Exclude or treat sleep apnea [54]

Optimize mitochondrial function CoQ or ubiquinol, a-lipoic acid, PQQ, NAC, ALCAR, Se, Zn, resveratrol, ascorbate, thiamine [55]

Increase focus Pantothenic acid Acetylcholine synthesis requirement
Increase SirT1 function Resveratrol [32]

Exclude heavy metal toxicity Evaluate Hg, Pb, Cd; chelate if indicated CNS effects of heavy metals

MCT effects Coconut oil or Axona [56]

---

quote:

---

I agree with this.

---

regardless of your position on recreational usage, to deny that there is any medical benefit to the plant (Sch1) is asinine, and the two posters who downvoted my post are completely ignorant to our scheduling system.

quote:

---

If only we let people smoke pot, then Alzheimer's would be cured and people would get to see with their third eye and society would be a better place.

---

You're usually pretty rational, but you're letting your hatred of "medical marijuana" blind you.