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Started By
Message
Clinical trial shows promise in reversing Alzheimer's disease
Posted on 6/20/16 at 4:55 pm
Posted on 6/20/16 at 4:55 pm
LINK
quote:
A highly-personalized combination treatment program reversed Alzheimer's disease symptoms in patients, according to researchers.
The Buck Institute investigators said their findings suggest the degenerative brain disease is more treatable than previously believed, United Press International reported.
The study included 10 people with mild cognitive impairment, subjective cognitive impairment or Alzheimer's disease. The researchers created personalized multi-faceted treatment programs for each patient, including diet changes, exercise, improved sleep, brain stimulation, drugs and vitamins.
The patients were treated for between five and 24 months. All 10 patients showed improvements in thinking and memory, and some were even able to return to work and complete tasks that had become impossible for them as their mental abilities declined, UPI reported.
5
Posted on 6/20/16 at 4:58 pm to Jim Rockford
While good news, this would still be very far from any practical application as there is a lot more research the program will have to go through. The FDA does not move quickly nor do clinical trials.
Posted on 6/20/16 at 5:00 pm to Jim Rockford
That would be amazing. My mom is starting to show signs of Alzheimer's and it fricking sucks.
Posted on 6/20/16 at 5:03 pm to Tingle
Get her tested, neuropsych eval, and then started on Aricept and/or Namenda early in the disease process if needed, since that is when they are most effective.
Posted on 6/20/16 at 5:03 pm to Jim Rockford
bullshite study. Taking depressed old patients and getting them to exercise and socialize increases cognition in all people. It just changes their baseline. They will still follow the cognitive decline caused by the disease.
This is not new stuff here. This is already known. But it is packaged up by some quack who is trying to sell stuff we already know as something new.
This is not new stuff here. This is already known. But it is packaged up by some quack who is trying to sell stuff we already know as something new.
Posted on 6/20/16 at 5:07 pm to PsychTiger
Will do. Thanks for the info. 
Posted on 6/20/16 at 5:08 pm to thetempleowl
The Bucks Institute is a legit research institute and is affiliated with the University of California system.
Posted on 6/20/16 at 5:10 pm to thetempleowl
My gramps had Alzheimer's and my biggest fear is that I one day will have it too. I don't want my life to end not being to able to remember it or the people that were a part of it. Although a very small study, it's hopeful to read. thanks for the share.
Posted on 6/20/16 at 5:16 pm to Jim Rockford
quote:
"The magnitude of improvement in these 10 patients is unprecedented, providing additional objective evidence that this programmatic approach to cognitive decline is hhighly effective," Dr. Dale Bredesen, a professor at the Buck Institute and the University of California Los Angeles, said in a news release.
Podcast
quote:
EPISODE 12: DALE BREDESEN DISCUSSES THE METABOLIC FACTORS UNDERLYING ALZHEIMER’S DISEASE
LINK
Low carb, ketogenic diet with fasting intervals and MCT oil....
Optimize Vit D, sleep, gut health...
quote:
GI health Repair if needed; prebiotics and probiotics Avoid inflammation, autoimmunity
Reduction of Aß Curcumin, Ashwagandha [43-45]
Cognitive enhancement Bacopa monniera, MgT [46, 47]
25OH-D3 = 50-100ng/ml Vitamins D3, K2 [48]
Increase NGF H. erinaceus or ALCAR [49, 50]
Provide synaptic structural components Citicoline, DHA [51].
Optimize antioxidants Mixed tocopherols and tocotrienols, Se, blueberries, NAC, ascorbate, a-lipoic acid [52]
Optimize Zn:fCu ratio Depends on values obtained [53]
Ensure nocturnal oxygenation Exclude or treat sleep apnea [54]
Optimize mitochondrial function CoQ or ubiquinol, a-lipoic acid, PQQ, NAC, ALCAR, Se, Zn, resveratrol, ascorbate, thiamine [55]
Increase focus Pantothenic acid Acetylcholine synthesis requirement
Increase SirT1 function Resveratrol [32]
Exclude heavy metal toxicity Evaluate Hg, Pb, Cd; chelate if indicated CNS effects of heavy metals
MCT effects Coconut oil or Axona [56]
This post was edited on 6/20/16 at 5:53 pm
Posted on 6/20/16 at 5:33 pm to Tingle
My mom has been tested and has the gene. Sometimes I wonder if I'm seeing signs or if I'm seeing signs because I know that she has the gene.
Posted on 6/20/16 at 5:57 pm to tiger91
There is some degree of natural cognitive decline with aging, and some who have the gene never meet full criteria for Alzheimer's.
Posted on 6/20/16 at 5:59 pm to PsychTiger
I was with my dad last week as he was getting a lumbar injection. We could hear the patient in the next room as the nurse was asking him questions. 94 years old, and razor sharp.
Posted on 6/20/16 at 6:00 pm to thetempleowl
quote:
This is not new stuff here. This is already known.
I agree
It should be common knowledge that the keys to health are:
nutrition
activity
sleep
stress management
Despite that, very few people (including physicians) actually place any value in the collective power of doing those things properly
If you listen to the talk I linked, Bredesen discusses the limitation of trials to evaluate the factors listed above. If you hear him speak (and his credentials), I think you may reconsider your "quack" comment...
Posted on 6/20/16 at 6:19 pm to PsychTiger
quote:
While good news, this would still be very far from any practical application as there is a lot more research the program will have to go through. The FDA does not move quickly nor do clinical trials.
So this guy proposes a lifestyle based approach to address this problem (I have listed the protocol above)
The protocol is mainly changes to nutrition, sleep, and activity with vitamin supplementation
What is the risk/benefit ratio for making said practical lifestyle changes that at a minimum will improve the overall health/wellness of the person and even possibly have an impact on the disease process?
Innovators innovate, science validates (often with serious lag time)...
This post was edited on 6/20/16 at 6:20 pm
Posted on 6/20/16 at 6:21 pm to ColoradoAg03
quote:
My gramps had Alzheimer's and my biggest fear is that I one day will have it too. I don't want my life to end not being to able to remember it or the people that were a part of it. Although a very small study, it's hopeful to read. thanks for the share.
My grandpa passed from it, and I'm terrified my dad will get it. He said the worst day of his life was when his dad (my grandpa) didn't recognize him.
Posted on 6/20/16 at 6:37 pm to Jim Rockford
Continue to pour in the money for research and the FDA continue to discredit it. Murica
Posted on 6/20/16 at 6:44 pm to ThinePreparedAni
+100 on your statements. These changes definitely aren't going to hurt the patient and the idea they may stall or reverse the decline are encouraging.
I work in the medical field and view most studies with extreme skepticism given the financial interests generally involved but realize that proper research should be vigorously encouraged. The last thing we want is to stop trying to solve the riddle.
I work in the medical field and view most studies with extreme skepticism given the financial interests generally involved but realize that proper research should be vigorously encouraged. The last thing we want is to stop trying to solve the riddle.
Posted on 6/20/16 at 6:50 pm to jbgleason
quote:
I work in the medical field and view most studies with extreme skepticism given the financial interests generally involved but realize that proper research should be vigorously encouraged. The last thing we want is to stop trying to solve the riddle.
As do I
Bredesen does a good job describing the limitations in conducting a trial with so many moving parts in the the linked podcast above
This post was edited on 6/20/16 at 6:57 pm
Posted on 6/20/16 at 6:57 pm to ThinePreparedAni
quote:
As do I
It was obvious. Which is why I made a serious comment vice a "hell yeah."
Posted on 6/20/16 at 7:06 pm to Tingle
quote:
Rockford
That would be amazing. My mom is starting to show signs of Alzheimer's and it fricking
I hope that this will help your mom if she's able to participate.
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