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Message
Long term SSRI use drawbacks
Posted on 10/1/25 at 3:15 pm
Posted on 10/1/25 at 3:15 pm
Cliff notes- went through a traumatic family event in June and was likely clinically depressed. Couldn’t sleep for more than an hour for a week straight and had crippling anxiety. Went on SSRI’s and got better in a week or two. The traumatic event is now over and I’m in a much better place now. Trying to come back down off the SSRI dosage now and am already feeling some anxiety and sleep loss creeping back in. Those of you who got off SSRI’s, did you just have to power through this phase and things got better? Or did you give up and just go back on them? Thanks.
30
Posted on 10/1/25 at 3:17 pm to GeneralLee
High dosage? You might need to wean. SSRIs linger in the system for a long time.
Posted on 10/1/25 at 3:18 pm to forkedintheroad
100mg was what I got up to… went back down to 50mg this past week.
Posted on 10/1/25 at 3:18 pm to GeneralLee
Which medication and what dose? Some are easier to taper off of than others.
Posted on 10/1/25 at 3:19 pm to GeneralLee
I think it is recommended that you taper off those drugs over a period of time. Cold turkey seems like it would be a rough ride.
Posted on 10/1/25 at 3:19 pm to SW2SCLA
Sertraline, 100mg
Posted on 10/1/25 at 3:21 pm to GeneralLee
Your prescribing physician or any family doctor should be able to walk you through the weaning process. It takes at least a few months. Quitting cold turkey is a terrible idea and will make your life miserable.
Posted on 10/1/25 at 3:22 pm to GeneralLee
I need SSRIs for my premature ejaculation.
Posted on 10/1/25 at 3:23 pm to GeneralLee
It takes time. Treat the withdrawal symptoms like the flu. Get plenty of fluids, vitamin D, B, exercise. Cut to 50 then 25 then 25 every other day.
ETA: the 7 days or 14 days bt cuts. Also, if you can go to a sauna or hot tub that helps too.
ETA: the 7 days or 14 days bt cuts. Also, if you can go to a sauna or hot tub that helps too.
This post was edited on 10/1/25 at 4:31 pm
Posted on 10/1/25 at 3:23 pm to GeneralLee
quote:
Sertraline, 100mg
50mg for 7 days, 25mg for 7 days, then you should be good. They make a 25mg tablet that you could break in half and do 12.5mg for another week if you want to be extra cautious. If you're over 60, maybe do 2 weeks at each dose
Eta: and talk to your doctor before you do anything
This post was edited on 10/1/25 at 3:25 pm
Posted on 10/1/25 at 3:24 pm to LSU Coyote
quote:
I need SSRIs for my premature ejaculation.
Posted on 10/1/25 at 3:26 pm to GeneralLee
quote:If you had situational depression, why did you need meds? I've always seen professionals say it's ok to be depressed when something depressing happens.
Cliff notes- went through a traumatic family event in June and was likely clinically depressed. Couldn’t sleep for more than an hour for a week straight and had crippling anxiety. Went on SSRI’s and got better in a week or two. The traumatic event is now over and I’m in a much better place now. Trying to come back down off the SSRI dosage now and am already feeling some anxiety and sleep loss creeping back in. Those of you who got off SSRI’s, did you just have to power through this phase and things got better? Or did you give up and just go back on them? Thanks.
Posted on 10/1/25 at 3:27 pm to LSU Coyote
mp yote 
Posted on 10/1/25 at 3:28 pm to GeneralLee
I am assuming sertraline, if your pecker is working fine and you aren't gaining weight I wouldn't worry about being on a low dose of say 50mg long term.
Posted on 10/1/25 at 3:29 pm to Big Scrub TX
Because I literally couldn’t sleep. Was getting dangerous for me to drive to work.
Posted on 10/1/25 at 3:30 pm to GeneralLee
No advice, just want to say good luck. Keep your chin up.
Posted on 10/1/25 at 3:31 pm to GeneralLee
Armchair psychiatrist chiming in but I find that if I can’t sleep a few beers helps as a natural remedy
This post was edited on 10/1/25 at 3:31 pm
Posted on 10/1/25 at 3:31 pm to GeneralLee
quote:
Weeks 1–2: Reduce to 75 mg daily.
Weeks 3–4: Reduce to 50 mg daily.
Weeks 5–6: Reduce to 25 mg daily.
Weeks 7+: Stop the medication completely.
Posted on 10/1/25 at 3:33 pm to armsdealer
quote:
I am assuming sertraline, if your pecker is working fine and you aren't gaining weight I wouldn't worry about being on a low dose of say 50mg long term.
20+ year user of 50mg Sertraline. No negative side affects, yet. Prescription expired a couple of times over the years and I took my time in setting a follow up appointment to renew it. Only immediate withdrawal side affect was my temper seemed short. That being said, I would still have a plan with your doctor for weaning off.
This post was edited on 10/1/25 at 3:38 pm
Posted on 10/1/25 at 3:35 pm to GeneralLee
Do not wean off SSRI without advice from a doctor. You can seriously get in a bad spot if you dont do it right and even then it's a bitch.
I tried to do it cold turkey and that was a HUGE mistake. and my doctors plan took a year to get off them without suffering severe depression. Its aint no joke.
I did this but over 1 year period - 100% to 75% to 50 % to 25 % to 12.5% and I still suffered at the end.
I tried to do it cold turkey and that was a HUGE mistake. and my doctors plan took a year to get off them without suffering severe depression. Its aint no joke.
quote:
Weeks 1–2: Reduce to 75 mg daily.
Weeks 3–4: Reduce to 50 mg daily.
Weeks 5–6: Reduce to 25 mg daily.
Weeks 7+: Stop the medication completely.
I did this but over 1 year period - 100% to 75% to 50 % to 25 % to 12.5% and I still suffered at the end.
This post was edited on 10/1/25 at 3:38 pm
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