Russia’s cancer vaccine to start human trials & be free to patients

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The mRNA-based vaccine is entirely individualised. "The drug is entirely personalized, created specifically for each patient using their unique tumor data, and cannot be used for anyone else."

Russia's first patients could begin receiving a newly developed personalised cancer vaccine within the next few months, state-run RT reported on Sunday, quoting Alexander Gintsburg, director of the Gamaleya Research Institute of Epidemiology and Microbiology.

Speaking to RIA Novosti, Gintsburg said, "In accordance with the plan approved by the Health Ministry, we are preparing to begin experimental treatment using the cancer vaccine based on neoantigens in a group of melanoma patients." The trials will be carried out at the Hertsen Research Institute and the Blokhin Cancer Center in Moscow, with the Gamaleya Center producing the vaccine.

The mRNA-based vaccine is entirely individualised. "The drug is entirely personalized, created specifically for each patient using their unique tumor data, and cannot be used for anyone else," Gintsburg said.

According to RT, development of the vaccine began in mid-2022. It uses messenger RNA (mRNA) and artificial intelligence to design customised treatments based on a patient’s genetic tumour profile. The therapy works by training the immune system to detect and destroy malignant cells using cytotoxic lymphocytes.

Due to its personalised nature, the vaccine falls under a separate regulatory process created by the Russian government earlier this year. “This is a fundamentally different process from the registration of standard drugs,” Gintsburg noted, adding that the team is working closely with the Health Ministry under the new guidelines.

The production cycle — from analysing tumour data to producing the vaccine — takes about a week with AI support, Gintsburg said. The vaccine has already shown promising results in animal studies and limited human trials.

Initially targeted at melanoma patients, the vaccine model is also being extended to other cancers including pancreatic, kidney, and non-small-cell lung cancer, which Gintsburg described as among the most difficult to treat.

According to Russia's Health Ministry, there are approximately 4 million cancer patients in the country, with 625,000 new diagnoses each year. If proven safe and effective, the new vaccine could mark a milestone in Russia’s personalised medicine programme. Gintsburg also said that "several foreign medical institutions have reached out to express a desire to collaborate."

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