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'Worst version of COVID' will be dominant in U.S. by July
Posted on 6/30/22 at 6:35 pm
Posted on 6/30/22 at 6:35 pm
'The worst version' of COVID is spreading. Can we update our vaccines in time?
quote:
For the last 18 months, the original COVID-19 vaccines — first as a two-dose series, then as boosters — have done an extraordinary job shielding us from illness, hospitalization and death. Globally, they saved nearly 20 million lives in 2021 alone. Even today, unvaccinated Americans are twice as likely as vaccinated Americans to test positive for COVID — and six times as likely to die from the disease.
But viruses evolve, and vaccines should too.
That was the big-picture takeaway from a pivotal meeting this week of the U.S. Food and Drug Administration’s expert advisory panel. The question before them was simple: Ahead of an expected winter surge, should vaccine manufacturers tweak their forthcoming booster shots to target Omicron — the ultra-infectious variant that has spent the last seven months surging throughout the world in one form or another — or should they stick with the tried-and-true 2020 recipe?
The panel voted 19-2 on Tuesday in favor of Omicron boosters. The question now, however, is which version of Omicron the next round of shots should target.
For anyone who hasn’t been paying attention, the Omicron strain that triggered last winter’s massive COVID wave (BA.1) is now extinct. In March, it was supplanted by the even more transmissible BA.2 … which was supplanted in May by the even more transmissible BA.2.12.1 … which is now being supplanted by the (you guessed it) even more transmissible BA.4 and BA.5.
Experts say BA.5 is the one to worry about: “The worst version of the virus that we’ve seen,” as Dr. Eric Topol, the founder of Scripps Research Translational Institute, recently put it. Together, the closely related BA.4 and BA.5 now account for the majority of new U.S. COVID cases, according to the latest data from the Centers for Disease Control and Prevention — but BA.5 (36.6%) is spreading a lot faster than BA.4 (15.7%). By early July, it will be the dominant strain in the U.S.
That’s troublesome for several reasons. To our immune system, the distance from BA.1 to heavily mutated BA.4 and BA.5 is “far greater,” Topol writes, than the distance from the original BA.1 virus to previous blockbuster variants such as Alpha and Delta — which makes them harder to recognize and respond to.
Posted on 6/30/22 at 6:36 pm to stout
Get you some more shots Covid Bros
Posted on 6/30/22 at 6:37 pm to stout
Ok, so now they need to list the hospitalization numbers. Crickets
Posted on 6/30/22 at 6:37 pm to stout
The only cure is mail in voting and more abortions
Posted on 6/30/22 at 6:37 pm to stout
Just in time for the mid terms.
Posted on 6/30/22 at 6:37 pm to stout
The Branch Covidians just nutted
Posted on 6/30/22 at 6:38 pm to stout
Lock it down. Shut everything down preemptively. Mask up. 8 masks.
Posted on 6/30/22 at 6:38 pm to Cosmo
quote:
The only cure is mail in voting and more abortions
They can use the aborted fetus fluid to sign the mail in forms.
Posted on 6/30/22 at 6:38 pm to stout
I’m thankful to be vaccinated and boosted. My wife’s two year old son thanked me on the way to school today for bringing him to get his booster. Had to hide the tears as he climbed out of my Sienna.
Posted on 6/30/22 at 6:39 pm to stout
Takeaway fron "worst version"
quote:
More breakthrough infections, especially among people who previously had BA.1. Compared to BA.2, BA.2.12.1 is only modestly (1.8-fold) more resistant to antibodies from vaccinated and boosted individuals. But BA.4 and BA.5 are substantially (4.2-fold) more resistant.
More symptoms. BA.4 and BA.5 are also better at replicating in lung cells than BA.2 — a shift that could mean, according to one experimental model, that they’re more “pathogenic” as well (i.e., more likely to make you sick).
More resistance to treatments. At the same time, BA.4 and BA.5 appear to be 20-fold more resistant than BA.2 to Evusheld — an important monoclonal antibody treatment that has been providing preemptive protection for immunocompromised people.
Posted on 6/30/22 at 6:40 pm to A Menace to Sobriety
quote:
Just in time for the mid terms.
Yup
Posted on 6/30/22 at 6:43 pm to stout
Hospital Pulmonologists and Intensivists...
Posted on 6/30/22 at 6:43 pm to stout
Lol imagine getting a vaccine and multiple boosters that don’t even work.
Posted on 6/30/22 at 6:44 pm to FredBear
Getting over my second bout with rona in 6 months, symptoms were the same both times. Low grade fever for 24 hours, made me miserable for a couple days. General fatigue for about 4 or 5 days with a nagging cough but today is my 6th day and I'm back to 90%. Still vaccine free and plan to stay that way, as someone that has had the flu several years back the rona doesn't have shite on it.
Posted on 6/30/22 at 6:48 pm to dgnx6
quote:
Lol imagine getting a vaccine and multiple boosters that don’t even work.
Even worse, imagine being forced to get it or be terminated
Posted on 6/30/22 at 6:53 pm to stout
2 weeks to flatten the curve for real this time folks. As long as we're saving lives.
Posted on 6/30/22 at 6:56 pm to TxWadingFool
quote:
Getting over my second bout with rona in 6 months, symptoms were the same both times. Low grade fever for 24 hours, made me miserable for a couple days. General fatigue for about 4 or 5 days with a nagging cough but today is my 6th day and I'm back to 90%. Still vaccine free and plan to stay that way, as someone that has had the flu several years back the rona doesn't have shite on it.
Yeah, I got it in January and I had a sore throat and was tired for about a week and then was fine, no worse than the regular flu. I'm never getting vaccinated either
Posted on 6/30/22 at 6:57 pm to stout
How much are these companies getting paid for every new vaccine?
Posted on 6/30/22 at 6:58 pm to stout
I currently have covid even though I refused to get tested. Wife works as a teacher, 3 year old goes to the same school. Small private school. Multiple kids/teachers tested positive. Son runs a fever, tired, etc. Two days later I get a fever and fatigue. Take Tylenol and fever gone in 5 hours. I’m on day 3 of a mild runny nose. If this is “the worst” then nobody has died of covid in the past. All with covid.
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