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re: Great news! Azithromycin & Chloroquine: victory lap

Posted on 3/21/20 at 11:44 am to
Posted by Hopeful Doc
Member since Sep 2010
15388 posts
Posted on 3/21/20 at 11:44 am to
quote:

For the MDs in here...based on what we(you) know,would you prescribe this cocktail and hope for a cure?



I would more or less fall in line with the UpToDate recommendation.

Funny thing is that's pretty much a solid summary of my feelings on it.

If you're hospitalized and worsening, I would consider it if you didn't have one of the many contraindications to it.

quote:

Or, would you be fearful of bad outcomes?


Let's just get this straight now:
Nothing is going to knock the mortality down to nothing. There are going to be bad outcomes regardless of what's done. When this shows any evidence of bettering outcomes, even in a high-risk of bias, poorly designed review, I'll be all over it. It's not even there. Reducing detectable virus in the nasal cavity means very little with regards to how the patients on it will do.


Numbers/data are one thing.

Lives saved are another.
Posted by Hopeful Doc
Member since Sep 2010
15388 posts
Posted on 3/21/20 at 11:47 am to
quote:

Is it just that you are holding out the possibility that all the people who took the drug combo were “cured” was a coincidence?


80% or more will get better with no intervention as it is.

quote:

Or is it you think that they were not actually “cured” and the data suggest they were is incorrect?

The data mentions Jack shite about how they felt or how sick they were to begin with.

I read a lot of posts in this thread to seem as if people are thinking, "these are 26 people that would have died that now have undetectable viral loads"

In reality, viral load is an essentially meaningless stat. Outcomes are far more important than that.


It does show some promise. But you're exactly right- a study this small could be almost purely coincidence. When more numbers come out, you'll see institutional protocols and professional societies endorse it.
I can promise you that they aren't behind the times on the data.


The data sucks.
Posted by Taxing Authority
Houston
Member since Feb 2010
63304 posts
Posted on 3/21/20 at 11:52 am to
quote:

Numbers/data are one thing.

Lives saved are another.
Well said.
Posted by NC_Tigah
Make Orwell Fiction Again
Member since Sep 2003
138812 posts
Posted on 3/21/20 at 11:52 am to
quote:

For the MDs in here...based on what we(you) know,would you prescribe this cocktail
If I didn't have Remdesivir, I'd certainly try Chloroquine.
quote:

hope for a cure?
No. Just to accelerate recovery.
quote:

would you be fearful of bad outcomes?
Fearful, no. Watchful, yes.
Posted by Hopeful Doc
Member since Sep 2010
15388 posts
Posted on 3/21/20 at 11:56 am to
quote:

Does anyone have insight on the other studies on this particular combination from around the world even if in vitro?


Check my UpToDate link from earlier. It's probably the most current and complete summary and cites everything. It uses.
Posted by oleyeller
Vols, Bitch
Member since Oct 2012
32604 posts
Posted on 3/22/20 at 6:31 pm to
quote:

Folks...we’re about to be out of the woods on this thing!



We all cured yet?
Posted by Little Trump
Florida
Member since Nov 2017
5817 posts
Posted on 3/22/20 at 6:33 pm to
NY Hospital reporting 100% cure on 100+ patients!!!
Posted by Janky
Team Primo
Member since Jun 2011
35957 posts
Posted on 3/22/20 at 6:34 pm to
Link?
Posted by AndyJ
Member since Jul 2008
3590 posts
Posted on 3/22/20 at 6:35 pm to
Yeah link?
Posted by Eli Goldfinger
Member since Sep 2016
32785 posts
Posted on 3/22/20 at 6:43 pm to
I saw the same interview.
Posted by CaptSpaulding
Member since Feb 2012
6974 posts
Posted on 3/22/20 at 6:52 pm to
quote:

But given the sparse data “we don’t know” is a perfectly fine answer. People forget admitting what one doesn’t know is very much part of the scientific process.


I think a frustration, at least for me, is that “we don’t know” isn’t being followed up with “but we are currently doing X,Y, and Z to learn more.” Right now everyone is just being told to stay home without any sort of timeline. That is not sustainable. Even if they were to say that studies are being done, but it will take 4 months at the earliest. That is almost as unsustainable as what we have now, but it’s at least an answer that people can begin to process. The vibe a lot of people who are presented as experts give off is that it’s just bullshite and they aren’t really interested in pursuing it. Just give us something.
Posted by CelticDog
Member since Apr 2015
42867 posts
Posted on 3/22/20 at 6:55 pm to
quote:

would you be fearful of bad outcomes?

Fearful, no. Watchful, yes.


brain damage


Posted by Eli Goldfinger
Member since Sep 2016
32785 posts
Posted on 3/22/20 at 6:57 pm to
Posted by Y.A. Tittle
Member since Sep 2003
110909 posts
Posted on 3/22/20 at 7:00 pm to
quote:


quote:
would you be fearful of bad outcomes?

Fearful, no. Watchful, yes.


brain damage
quote:

CelticDog


What’s your background to be able to make such a postulation? Lay it out.
Posted by mmcgrath
Indianapolis
Member since Feb 2010
37341 posts
Posted on 3/22/20 at 7:01 pm to
quote:

A clinic in AL that I’m very familiar with now has enough to treat 70 people.
A clinic? In Alabama? Seems like they missed the hot spots here.
Posted by Eli Goldfinger
Member since Sep 2016
32785 posts
Posted on 3/22/20 at 7:01 pm to
quote:

The vibe a lot of people who are presented as experts give off is that it’s just bull shite and they aren’t really interested in pursuing it


I can assure you that this combo of drugs is effective, is currently in use, and production has been ramped up.
Posted by oleyeller
Vols, Bitch
Member since Oct 2012
32604 posts
Posted on 3/22/20 at 7:05 pm to
quote:

I can assure you that this combo of drugs is effective


Lmfao.. our own TD scientist at work.#blessed
Posted by Muleriderhog
NYC
Member since Jan 2015
3116 posts
Posted on 3/22/20 at 7:08 pm to
quote:

Lmfao.. our own TD scientist at work.#blessed

Lil bitch boy oleyeller is still a dumbass.

You’re making a run for dumbest person on the PB, that’s quite an accomplishment.
Posted by LSURussian
Member since Feb 2005
134870 posts
Posted on 3/22/20 at 7:10 pm to
quote:

brain damage
Do you speak from experience??
Posted by oleyeller
Vols, Bitch
Member since Oct 2012
32604 posts
Posted on 3/22/20 at 7:14 pm to
quote:

Lil bitch boy oleyeller is still a dumbass.

You’re making a run for dumbest person on the PB, that’s quite an accomplishment.


I mean its been 2 days. I figured this would be mainstream now, and everyone getting the treatment and cured. But as expected, just more bullshite for like minded sheep such as you to believe and push.
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