re: Daily COVID Updated as of 11/2/20 8:00 PM

So at what point is it decided that they won’t come off? Family decision based on MD provided info? I mean you can’t stay on a vent forever. Do people finally just die?? (Don’t mean that ugly but idk how else to say it)

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So at what point is it decided that they won’t come off?

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it's not really a decision like youre thinking about.

I'm saying we try to lower vent settings, try to get the patient off the vent, and they dont tolerate it. they NEED it to stay alive

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and there are only 50k people infected

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He's clearly referring to confirmed cases, which at this moment is 54,808.

Good post

Just curious, do you know where I can learn about testing systems in Europe?

I thought they were similar to South Korea, but i guess not?

He says as he ignores the subsequent posts. Damn single variable thinkers

I can’t think of a single god damn thing I’ve been wrong about since I started posting about this.

My post on page one of this very thread that got admonished in downvotes for simply saying deaths are a lagging indicator looks pretty accurate now.

95% of this board has exposed themselves as brain dead mouth breathers.

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It’s just hard to wrap my brain around. Someone make me feel better and a way to understand this.

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I'll shoot.

In general, it is a virus and has to run it's course. And I have been trying to put the fear of God in my relatives that are 70 and over. If this group listens and stay isolated, the number of serious cases will not spike nearly as bad as suggested. Once we feel like we are able to handle the hospital bed situation, life will get back close to normal for most folks 65 and below, with maybe some better awareness of how not to spread an airborne virus.

As far as vaccines go, we are technically ahead of where you would normally be this early in a pandemic because the "spike protein" that sticks off of the virus particle, the "corona", happens to be very similar to the SARS-1 virus, which makes sense as they are in the same family of betacoronaviruses. And because of this, they have already mapped out amino acid sequences that elicit T cell immunity (T cells kill the infected cells) and B cell immunity (B cells mature to plasma cells and produce antibody). They are in development already. These small amino acid sequences will be produced as recombinant proteins in huge quantities and will be used as a vaccine. High likely hood they will be effective because of the fact that young adults and kids are probably spared from the serious cases because they have some pre-existing immunity due to exposure of other corona viruses in school and have immune memory, so we can feel pretty confident that a good vaccine will be developed. And hopefully effective for the viral family so that SARS-3 will not put us in the same boat.

There are also patients that have cleared this virus and have antibodies in their serum. There are trials being conducted to see if the serum from these people can help those in very serious condition.

Finally, trials looking at the generic drug losartan are also starting. 1000 patient trial through Univ of Minnesota. Viral load readouts will happen in weeks. If there is a positive effect, doctors can start using it off label. (It is a very popular blood pressure drug anyway that many people are on.) It is a direct inhibitor to the receptor that the virus uses to infect cells.

The reason that it is important that generic, FDA approved drugs (this include azithromycin and hydroxycholoquine) may work is that all it takes is an interim endpoint, like 3 or 5 day viral load decrease, to show some effect and be published (like the french paper) and US doctors can prescribe these off label drugs and it can become standard of care in weeks.

No one knows the future, but finding a therapeutic intervention for this, whether immunologic or generic med, is not years away, but probably can be measured in months. And we don't have to cure it. We only have to decrease the number of serous cases/deaths and we get back to our baseline of knowing that viruses happen during the flu season. We just are not there yet and things will evolve rapidly over the next month or 2, for better or worse, but I am leaning towards the better.

Yes I know that they need it — I truly get that. But are these people going to stay on a vent forever if their conditions don’t improve enough to come off?

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At this point, I don't think testing would have prevented lockdowns

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Only a foolish person thinks we would've been able to stop the spread in a country as big as the US.

The government would've had to take EXTREME measures and there is no way the American public would go with that