Potential Move to Western Colorado

A bit off topic, but I come to my OB Brethren for sound advice. Long time lurker, and I rarely post. My wife and I lived in Pass Christian right out of college, but life took us other places over the last 10 years. It became a goal of ours to move back to the Pass to raise our kids. We achieved that goal and have been back down here for a few months. I have had a much harder time finding employment on the Coast than we expected. I have worked in construction for the past 6 years mainly in stone countertops and electrical. My wife was doing very well, until being laid off due to her company's contracts being strongly tied to USDA funding. I have been looking into getting back into teaching, which is what my degree is in. She has a few offers that would come with a substantial pay cut. We are not in an urgent position due to a healthy savings account.

Here's the Colorado option. I have a good friend that has connected me with his company based out of Denver. I'm quickly progressing through the interview process to the point of potentially being flown out to Grand Junction to meet with the staff in that office. I would be in construction sales and be tasked with helping establish a sales base in the Aspen and Vale region. The position is designed to start as salary plus commission and transition into uncapped 100% commission as I establish a book of clients. The kicker is even with the potential of 100-120,000 starting out that seems to be stretching it for the entire region. They don't want me to live in Grand Junction as I would only need to report to the office a few times a month, and they want me to be near clients. 3 bed 2 bath homes an hour outside of Aspen are upwards of a million dollars. 2 bed 1 bath rentals are 2-3,000 a month, which is more than our mortgage.

I guess my question for you folks with more life experience, do ya'll think this is worth it? We have a 3 year old son and a 9 month old daughter. Our son is in a great catholic school over in the Bay and our daughter is due to start there in August, all of our family is in Mississippi or Louisiana aside from a few cousins in the Raleigh area, and a cousin in Austin. Our house is right downtown; I can see the Pass pavilion and the olive oil shop from my bedroom window. I was driving home from Wal-Mart yesterday and saw Pass Harbor in the distance and had a hard time coming to terms with leaving, again. We can do fine here. I can go teach high school, my wife can take 1 of 2 offers she has and we'll have a household income in the 110 range, which will also increase over the years. The potential earnings over even a 10 year period in Colorado could be life changing, but damn we love this place. Honestly, if I had a decent job and my wife wouldn't have gotten laid off we wouldn't even be considering this.

Apologies for the wall of text. Give me your thoughts!