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re: So now that we have a bonafide cure for this Corona virus can we open everything back up?

Posted on 3/18/20 at 11:29 pm to
Posted by noonan
Nassau Bay, TX
Member since Aug 2005
36951 posts
Posted on 3/18/20 at 11:29 pm to
Are you just saying it's not a vaccine?

I guess what you're saying is technically it's not a cure, it just speeds up the recovery process so you're body can get rid of the virus and you don't die.

It's basically the big salad of the medical world. Or more accurately, it's George's girlfriend in the big salad episode.
This post was edited on 3/19/20 at 12:01 am
Posted by dgnx6
Member since Feb 2006
79595 posts
Posted on 3/18/20 at 11:30 pm to
quote:

I agree, but that wouldn't stop the medical malpractice/personal injury lawyers from filing suit, especially if all the positive talk on the internet about hydroxychloroquine doesn't pan out. "Did you or your loved suffer an injury or die from taking the drug hydroxychloroquine for Covid-19 despite it not being approved for this by the FDA nor recommended by the CDC? Call1-800-COVID19 for a free consultation."



We've been giving this out to the military for a very long time so they don't catch shite like malaria.

Some of yall really want this thing to be worse than it is.
Posted by vince vega
New Orleans
Member since Feb 2014
754 posts
Posted on 3/18/20 at 11:30 pm to
the hopeful part implies he's still taking pre reqs
Posted by cardswinagain
Member since Jun 2013
12756 posts
Posted on 3/18/20 at 11:33 pm to
Cure it tomorrow. March Madness begins Friday!
Posted by Big_Slim
Mogadishu
Member since Apr 2016
3978 posts
Posted on 3/18/20 at 11:34 pm to
quote:

Some of yall really want this thing to be worse than it is.


It’s the weirdest god damn thing I’ve ever seen. I understand the speculation in this thread just because it does sound too good to be true, more speaking to general trends across the board from the past week.
Posted by JPLSU1981
Baton Rouge
Member since Oct 2005
26970 posts
Posted on 3/18/20 at 11:35 pm to
Does spread even matter if there’s a cheap at-home option to treat/cure the virus?
Posted by League Champs
Bayou Self
Member since Oct 2012
10340 posts
Posted on 3/18/20 at 11:36 pm to
quote:

it doesn't do much for the general public as far as slowing the spread

Eradicating it is 6 days doesn't do much for the general public? It puts everyone and ease, and immediately back to work.

And no one cares about the spread any longer.
Posted by Hopeful Doc
Member since Sep 2010
15388 posts
Posted on 3/18/20 at 11:38 pm to
quote:

within six days using this med in combination with erythromycin, and COVID was no longer detected in 100% of the patients



I haven't seen this. I have seen it referenced in conjunction with azithromycin to reduce detectable virus in around 95% of cases. Here is a medscape (free but you have to register) publication on it. It's a few days old updated and republished today.


There's some promise.


It's not a "bona-fide cure"
It's efficacy in the critically ill isn't established with good data at this time.
We don't currently have good data on the caseload to begin with, and it's currently believed that 80% who contract it will do fine with no treatment at all.



This isn't something that everyone should go out and start just yet.
Posted by Buttoncollector
S'boro
Member since Jun 2011
576 posts
Posted on 3/18/20 at 11:38 pm to
If the FDA makes it “on label” that would give the Drs cover from liability maybe? No way do I understand that but just hoping.

Chloroquine Has been banned from being exported from the U.K. (along with some other HIV drugs that they thought may help). Also I’ve read where it was OTC there as a “travelers medication”.
Posted by Big_Slim
Mogadishu
Member since Apr 2016
3978 posts
Posted on 3/18/20 at 11:41 pm to
quote:

Hopeful Doc


Solid points. Definitely need more data but no one is gonna stop me from getting prematurely excited about this
Posted by Oates Mustache
Member since Oct 2011
24362 posts
Posted on 3/18/20 at 11:44 pm to
quote:

Hopeful Doc


You might be a better fit in the gloom and doom stickied thread. There are very numerous stories from a variety of countries now using it with great success so far.

We're not living in the same world from 2 weeks ago, we're under a federally declared emergency in the entire country. If it even sniffs being promising, they're gonna approve it for treatment, removing the FDA red tape.
Posted by Buttoncollector
S'boro
Member since Jun 2011
576 posts
Posted on 3/18/20 at 11:47 pm to
quote:

This isn't something that everyone should go out and start just yet.


I’m thinking of starting a Gin and Tonic regimen

We are learning what “Practicing Medicine” really means these days
Posted by Steadyhands
Slightly above I-10
Member since May 2016
7043 posts
Posted on 3/18/20 at 11:52 pm to
quote:

Going to be a long 18mts for you


I hope it is... working from home is great so far. Honestly I believe I was more productive. Better check myself and not forget that I only need to out perform everyone else, which is primarily boomers. Never give 100%, only ever give 110% of what everyone else does. Kind of sucks sometimes though, when it leaves you with 50% downtime some days. Ah well, just means I can actually take a nap now that I'm at home, or work on something around the house.
Posted by Hopeful Doc
Member since Sep 2010
15388 posts
Posted on 3/18/20 at 11:55 pm to
quote:

If the FDA makes it “on label”



That's not really how this works. The FDA doesn't just add indications to the label, and they definitely don't do it based on very weak observational nonblinded data in the midst of a crisis with unknown case numbers with inadequate information from other countries with different reporting standards and...I think you get the point


But "labeled" indications aren't required for a treatment to become the "standard of care."
Doctors don't just not write this medication because it's not technically approved for this. Most of them are aware that there are some case reports and some observations and some fairly weak "trials" showing some efficacy. The data just isn't overwhelmingly convincing at this point. If it were, there would be breaking treatment guideline recommendations by the CDC, WHO, and professional societies (critical care, pulm, ACP, and possibly even AAFP/AAP depending on the data available, who it helped, and where they were treated).


If I were diagnosed with COVID19 tomorrow, I wouldn't take it. And if my wife got it, I wouldn't give it to her.
If either of us were tanking in the hospital and the attending physician wanted to give it a try, I probably wouldn't say no, either.


People thinking this is a beurocratic, red-tape, over-regulated fiasco aren't quite getting it. Yes- you could argue that there is far too much of those things, but that's not what's preventing everyone from getting on this medication and this "outbreak" getting quashed. It's a lack of convincing evidence that that is what is going to happen.
Posted by Buttoncollector
S'boro
Member since Jun 2011
576 posts
Posted on 3/18/20 at 11:59 pm to
Understand your labeling Info, thanks

quote:

If I were diagnosed with COVID19 tomorrow, I wouldn't take it.


In your opinion what would be the down side of trying it?
This post was edited on 3/19/20 at 12:00 am
Posted by Hopeful Doc
Member since Sep 2010
15388 posts
Posted on 3/19/20 at 12:10 am to
quote:

In your opinion what would be the down side of trying it?


I'm low risk of complications from the virus to begin with, and quarantine would be safer than treating.
Being sick is part of life, this is no different. I don't typically treat viral symptoms in myself. Getting better faster doesn't mean I should go back to work faster, given the high-risk populations I deal with on a daily basis.
Pancytopenia leading to secondary and more severe infection
Torsades
Posted by noonan
Nassau Bay, TX
Member since Aug 2005
36951 posts
Posted on 3/19/20 at 12:15 am to
Basically the people that will likely recover on their own don't need to take it. But it very well could, and kinda does, help people that could otherwise die from corona. So those people should probably take it.
This post was edited on 3/19/20 at 12:17 am
Posted by Buttoncollector
S'boro
Member since Jun 2011
576 posts
Posted on 3/19/20 at 12:16 am to
That makes a lot of sense....not the last part of course but the overall logic thanks
Posted by Hopeful Doc
Member since Sep 2010
15388 posts
Posted on 3/19/20 at 12:34 am to
quote:

Basically the people that will likely recover on their own don't need to take it



The study linked here compares the "literature" rate of how "contagious" people are to those getting the med at day 6, and at day 6 in the study, 25% are still contagious.
They state they are collecting swabs in a hospital setting but aren't clear if they are referencing the lab or the patients
They do not cite the "literature" rate of how "contagious" people are in other studies.
One guy in this thread even confused which second medication was added (though he did get that it was a macrolide) and misrepresented the "clearance" rate of the virus, stating it cured 100% of people, when in reality, based on the link above, an unlisted number that isn't higher than 24 people got both drugs, and their rate of positivity was still 5% at day 6.


This isn't even close to proof or good evidence.

quote:

But it very well could, and kinda does, help people that could otherwise die from corona.


There are some other data out there that show some promise. I wouldn't bash a coworker for giving nor holding it at this point. There isn't a ton of good data for its use.

And as linked in the medscape article above (again, free to get into but you need to make an account- it's not a true 'paywall'), they excluded tons of the really critically ill patients from treatment with it because it interacts with a lot of drugs they were taking. Other investigative therapies show promise and safety, as well.



My point isn't "this isn't going to work."
My point isn't "no one should take this medication"
My point isn't "you should be near death before considering this medication"




My point is that no one who treats patients for a living thinks this is a bonafide cure with phenomenal data to support its use at this time
My point is that the folks in here saying something to the effect of "why doesn't everyone take it and we go back to normal life" don't understand just how little support there is for that idea, that the drug does have very real and severe side effects, and that the few trials that are out there really aren't a rock-solid foundation for worldwide adoption at this time.




I'm still hopeful, I promise.
I'm not as doom-and-gloom as some are reading me to be.
Posted by Havoc
Member since Nov 2015
34360 posts
Posted on 3/19/20 at 12:39 am to
Another win for Darwinism.
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