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Scientists develop Fentanyl vaccine

Posted on 11/20/22 at 6:30 pm
Posted by WaWaWeeWa
Member since Oct 2015
15714 posts
Posted on 11/20/22 at 6:30 pm
LINK

quote:

Texas-based researchers have developed a vaccine that blocks the euphoric effects of fentanyl, a potent synthetic opioid that is increasingly involved in opioid overdose deaths in the United States.


quote:

In studies in male and female mice, the vaccine generated significant and long-lasting levels of anti-fentanyl antibodies that were highly effective at reducing the antinociceptive, behavioral, and physiological effects of the drug. The vaccine prevents fentanyl from entering the brain. "Thus, the individual will not feel the euphoric effects and can 'get back on the wagon' to sobriety," lead investigator Colin Haile, MD, PhD, with University of Houston in Texas and founding member of the UH Drug Discovery Institute, said in a news release. The study was published online October 26 in the journal Pharmaceutics. "The anti-fentanyl antibodies were specific to fentanyl and a fentanyl derivative and did not cross-react with other opioids, such as morphine. That means a vaccinated person would still be able to be treated for pain relief with other opioids," said Haile. The vaccine did not cause any adverse effects in the immunized mice. The research team plans to start manufacturing clinical-grade vaccine in the coming months with clinical trials in humans planned soon.


Who is ready for the next jab?

Why would someone who wants to get high on fentanyl take a vaccine for it?

You can’t catch fentanyl like a cold. If you don’t want to die from fentanyl just don’t take fentanyl.
Posted by OweO
Plaquemine, La
Member since Sep 2009
113964 posts
Posted on 11/20/22 at 6:32 pm to
Its a virus?
Posted by LegendInMyMind
Member since Apr 2019
54315 posts
Posted on 11/20/22 at 6:32 pm to
quote:

Texas-based researchers have developed a vaccine that blocks the euphoric effects of fentanyl,

That's cool.

Could they not try a little harder and develop one that blocks the killing effects of it?

Now, you'll still OD, but you just won't have any of that amazing opiod hit to carry you out. That's just disrespectful.
This post was edited on 11/20/22 at 6:34 pm
Posted by BigBobbyStorey
New Lodge, Belfast
Member since May 2021
1058 posts
Posted on 11/20/22 at 6:32 pm to
psh why they tryin to ruin my good time
Posted by sledgehammer
SWLA
Member since Oct 2020
3377 posts
Posted on 11/20/22 at 6:33 pm to
They should name it after George Floyd.
Posted by SelaTiger
Member since Aug 2016
18003 posts
Posted on 11/20/22 at 6:34 pm to
frick that if I’m going to die from fentanyl I’d like to go out feeling good.
Posted by WaWaWeeWa
Member since Oct 2015
15714 posts
Posted on 11/20/22 at 6:36 pm to
quote:

Could they not try a little harder and develop one that blocks the killing effects of it? Now, you'll still OD, but you just won't have any of that amazing opiod hit to carry you out. That's just disrespectful.


It blocks all of the effects of the drug. You wouldn’t die from it.
Posted by armsdealer
Member since Feb 2016
11508 posts
Posted on 11/20/22 at 6:38 pm to
The problem with fentanyl isn't people intentionally taking it is people taking other things laced with it. This is dumb.
Posted by Booyow
Member since Mar 2010
3999 posts
Posted on 11/20/22 at 6:38 pm to
quote:

It blocks all of the effects of the drug. You wouldn’t die from it.


That’s not what I read in what OP posted
Posted by LegendInMyMind
Member since Apr 2019
54315 posts
Posted on 11/20/22 at 6:40 pm to
quote:

It blocks all of the effects of the drug. You wouldn’t die from it.

Okay. Let's do the reverse.

Could they not try a little harder and not block the euphoric effects of the drug? What....saving lives wasn't enough, they've gotta take away the high, too? That's just disrespectful.
Posted by Ed Osteen
Member since Oct 2007
57490 posts
Posted on 11/20/22 at 6:40 pm to
This already exists, it’s called Vivitrol

Didn’t realize it’s fentanyl specific, interesting but not really sure that’s very practical
This post was edited on 11/20/22 at 6:44 pm
Posted by ManBearTiger
BRLA
Member since Jun 2007
21848 posts
Posted on 11/20/22 at 6:40 pm to
quote:

Why would someone who wants to get high on fentanyl take a vaccine for it?


This may come as a shock to you but fentanyl is also legitimately used as a pharmaceutical pain killer and not everyone with ailments is seeking a psychoactive high
Posted by WaWaWeeWa
Member since Oct 2015
15714 posts
Posted on 11/20/22 at 6:41 pm to
quote:

That’s not what I read in what OP posted


“anti-fentanyl antibodies that were highly effective at reducing the antinociceptive, behavioral, and physiological effects of the drug. The vaccine prevents fentanyl from entering the brain.”

It blocks the physiological effects of the drug. Which means it isn’t going to get to the breathing centers of the brain and tell your body to stop breathing.

That’s how you OD.
Posted by WaWaWeeWa
Member since Oct 2015
15714 posts
Posted on 11/20/22 at 6:42 pm to
quote:

This may come as a shock to you but fentanyl is also legitimately used as a pharmaceutical pain killer and not everyone with ailments is seeking a psychoactive high


I’m well aware of that. What’s your point?
Posted by Hook Em Horns
350000 posts
Member since Sep 2010
15093 posts
Posted on 11/20/22 at 6:44 pm to
Wrong, it’s called suboxone.
Posted by Ed Osteen
Member since Oct 2007
57490 posts
Posted on 11/20/22 at 6:46 pm to
Vivitrol is just extended release naltrexone in a shot form. Monthly versus a daily pill
This post was edited on 11/20/22 at 6:48 pm
Posted by Hook Em Horns
350000 posts
Member since Sep 2010
15093 posts
Posted on 11/20/22 at 6:48 pm to
Yes and it doesn’t work worth a frick. Nothing can stay in your bloodstream for a month. Just ain’t happening.
Posted by OysterPoBoy
City of St. George
Member since Jul 2013
35173 posts
Posted on 11/20/22 at 6:49 pm to
Can they get to work on mosquito bites next?
Posted by Ed Osteen
Member since Oct 2007
57490 posts
Posted on 11/20/22 at 6:49 pm to
quote:

Yes and it doesn’t work worth a frick. Nothing can stay in your bloodstream for a month. Just ain’t happening.


I can personally tell you it works with alcohol for a month plus a couple of additional days to fully feel the euphoria of being drunk
This post was edited on 11/20/22 at 6:51 pm
Posted by East Coast Band
Member since Nov 2010
62798 posts
Posted on 11/20/22 at 6:50 pm to
I can see it now. Biden will try to mandate it. You know to "protect us" from all the drugs coming across his open Southern border. And when we all balk at being forced to take it, he'll spew out we're not caring about the underprivileged immigrants.
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